DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cd36 and pes

DIOPT Version :9

Sequence 1:	NP_001153027.1	Gene:	Cd36 / 12491	MGIID:	107899	Length:	472	Species:	Mus musculus
Sequence 2:	NP_001137808.1	Gene:	pes / 34087	FlyBaseID:	FBgn0031969	Length:	555	Species:	Drosophila melanogaster

Alignment Length:	477	Identity:	123/477 - (25%)
Similarity:	219/477 - (45%)	Gaps:	36/477 - (7%)

- Green bases have known domain annotations that are detailed below.

Mouse     5 RNCGLIAGAVIGAVLAVFGGILMPVG--DMLIEKTIKREVVLEEGTTAFKNWVKTGTTVYRQFWI 67
            |:|..: |.|:..:..:..||.:...  || ..:...:|:.|...:.:|:.|..:...:....::
  Fly     6 RHCARL-GIVLLGICCIASGIYLFRNWIDM-FTRMRGQEMALSPNSRSFEGWKVSPLPLDFDIYL 68

Mouse    68 FDVQNPDDVAKNSS-KIKVKQRGPYTYRVRYLAKENITQDPEDHTVSFVQPNGAIFEPSLSVGTE 131
            |:..||||....|: |...:|.|||.:|.: ..|.:|.....:.:|||.:.:...|:.:.|.|:.
  Fly    69 FNWTNPDDFYVGSNKKPHFEQLGPYRFREK-PDKVDIEWHNHNASVSFHKKSWFYFDAAGSNGSL 132

Mouse   132 DDNFTVLN-LAVAAAPHIYQNSFVQVVLNSLIKKSKSSMFQTRSLKELLW-GYKDPFLSL----- 189
            .|..|.:| :|.:||.....:.|.:..:|...|..:..:..|:::.|:|: ||:.||:|:
  Fly   133 WDKVTTVNSVAHSAARRAAVDWFARTGVNIANKLYRQGVTITKTVDEMLFKGYEHPFISVGKLLR 197

Mouse   190 ---VPYPISTTVGVFYPYNDT--VDGVYKVFNGKDNISKVAIIESYKGKRNLSYWPSYCDMINGT 249
               |||   ..:|..||.|.:  .||...:|.|.|:|:|:..|.::....:...:...|..::|:
  Fly   198 PQDVPY---KRIGYHYPRNGSSEFDGDINMFTGADDIAKMGQIHTWNNLTHTGAFEGTCGQVHGS 259

Mouse   250 DAASFPPFVEKSRTLRFFSSDICRSIYAVFGSEIDLKGIPVYRFVLPANAFASPLQNPDNHCFCT 314
            ....|||.:....|:..:...:||:|...:...:.:.|:..|:|....:|..:....||..|:|
  Fly   260 MGEFFPPNLGTKDTVYMYMPKMCRAIPLDYVETVTVHGVTAYKFSGTRHAVDNGTLYPDTRCYC- 323

Mouse   315 EKVISNNCTSYGVLDIGKCKEGKPVYISLPHFLHASPDVSEPIEGLHPNEDEHRTYLDVEPITGF 379
               :...|...||::||.|.....||:|.|||..|.|...|.||||.|..::|..::.:||..|.
  Fly   324 ---VGGKCMPSGVINIGPCSFNASVYMSFPHFYMADPSYLEAIEGLRPEREKHEFFMALEPNAGV 385

Mouse   380 TLQFAKRLQVNILVKPARKIEALKNLKRPYIVPILWLNETGTIGDEKAEMFKTQVTGKIKLLGMV 444
            .:......|.|..::|...|...:|:. ..::|::|..|...:.:|.|.  ...:...|.|||.:
  Fly   386 PMDVGGGFQANYYMEPIPGITLYENVP-TVMIPMMWCEERVRVSEEIAA--DIALVPLIVLLGQI 447

Mouse   445 EMALLGIGVVMFVAFMISYCAC 466
            ...:|..|.::        |.|
  Fly   448 VTGILLAGGLI--------CTC 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cd36	NP_001153027.1	CD36	16..463	CDD:366481	117/461 (25%)
		Required for interaction with thrombospondins, THBS1 and THBS2. /evidence=ECO:0000269\|PubMed:15748999	93..120		6/26 (23%)
		Interaction with PTK2, PXN and LYN. /evidence=ECO:0000250\|UniProtKB:P16671	460..472		2/7 (29%)
pes	NP_001137808.1	CD36	14..463	CDD:279474	120/468 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3776
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X155
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810