DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cct7 and CCT1

DIOPT Version :9

Sequence 1:	NP_031664.3	Gene:	Cct7 / 12468	MGIID:	107184	Length:	544	Species:	Mus musculus
Sequence 2:	NP_524450.2	Gene:	CCT1 / 42649	FlyBaseID:	FBgn0003676	Length:	557	Species:	Drosophila melanogaster

Alignment Length:	536	Identity:	191/536 - (35%)
Similarity:	289/536 - (53%)	Gaps:	33/536 - (6%)

- Green bases have known domain annotations that are detailed below.

Mouse    12 GTDSSQGIPQLVSNISACQVIAEAVRTTLGPRGMDKLIVDGRGKATISNDGATILKLLDVVHPAA 76
            ||..| |......|:.|...|:..|:::|||.|:||::||..|..|::|||||||:||:|.||||
  Fly    12 GTRQS-GASVRTQNVMAALSISNIVKSSLGPVGLDKMLVDDIGDVTVTNDGATILRLLEVEHPAA 75

Mouse    77 KTLVDIAKSQDAEVGDGTTSVTLLAAEFLKQVKPYVEEGLHPQIIIRAFRTATQLAVNKIKEIAV 141
            |.||::|:.||.|||||||||.:||||.||.....|::.:||..||..:|.|.:.|...|.|...
  Fly    76 KVLVELAQLQDEEVGDGTTSVVILAAELLKNADELVKQKIHPTSIISGYRIACKEACKYISEHLT 140

Mouse   142 TVKKQDKVEQ--RKMLEKCAMTALSSKLISQQKVFFAKMVVDA---VMMLDELLQ----LKMIGI 197
            .     .|::  |..|...|.|::|||:|.....||:.|||||   |.:.|...|    :|.|.:
  Fly   141 A-----PVDELGRDSLINIAKTSMSSKIIGADAEFFSAMVVDAAQSVKITDPRGQAAYSIKAINV 200

Mouse   198 KKVQGGALEESQLVAGVAFKKTFSYAGFEMQPKKYKNPKIALLNVELELKAEKDNAEIRVHTVED 262
            .|..|.:..||.|:.|.|...|.:   .:..|||..|.|||.|:..|:....|...::.::..:.
  Fly   201 LKAHGKSARESVLIPGYALNCTIA---SQQMPKKIVNAKIACLDFSLQKTKMKMGVQVLINDPDK 262

Mouse   263 YQAIVDAEWNILYDKLEKIHQSGAKVILSKLPIGDVATQYFADRDMFCAGRVPEEDLKRTMMACG 327
            .:||...|.:|..:::..|..:|..|:|....:.|:..:||.:.......||.:.|||....|.|
  Fly   263 LEAIRARELDITKERINMILGTGVNVVLVSGGVDDLCMKYFVEAGAMAVRRVKKSDLKIIAKATG 327

Mouse   328 GSIQTSV------NALVPDVLGHCQVFEETQIGGERYNFFTGCPKAKTCTIILRGGAEQFMEETE 386
            .:..||:      .:....::|......:.:|..:......|.......:|||||..:.:.:|.|
  Fly   328 AAFITSLTNMDGEESFDASMVGEAAEVAQERICDDELILIKGTKARAAASIILRGPNDFYCDEME 392

Mouse   387 RSLHDAIMIVRRAIKNDSVVAGGGAIEMELSKYLRDYSRTIPGKQQLLIGAYAKALEIIPRQLCD 451
            ||:|||:.:|:|.:::..||||||.:|..||.||.:::.::..::||.|..:||:|.:||:.|..
  Fly   393 RSVHDALCVVKRVLESKKVVAGGGCVEAALSIYLENFATSLASREQLAIAEFAKSLLVIPKTLSV 457

Mouse   452 NAGFDATNILNKLRARHAQGG--------MWYGVDINNENIADNFQAFVWEPAMVRINALTAASE 508
            ||..|||:::.|||:.|....        .|.|:|:....:.||.:|.|.||||.:|.:|..|:|
  Fly   458 NAAKDATDLVAKLRSYHNSSQTKPERSDLKWTGLDLIEGVVRDNKKAGVLEPAMSKIKSLKFATE 522

Mouse   509 AACLIVSVDETIK-NP 523
            ||..|:.:|:.|| ||
  Fly   523 AAITILRIDDMIKLNP 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cct7	NP_031664.3	chap_CCT_eta	3..525	CDD:274086	191/536 (36%)
		TCP1_eta	5..525	CDD:239456	191/536 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	523..544		1/1 (100%)
CCT1	NP_524450.2	TCP1_alpha	12..538	CDD:239451	189/534 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60896
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820