DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cct5 and CCT4

DIOPT Version :9

Sequence 1:	NP_031663.1	Gene:	Cct5 / 12465	MGIID:	107185	Length:	541	Species:	Mus musculus
Sequence 2:	NP_609579.1	Gene:	CCT4 / 34674	FlyBaseID:	FBgn0032444	Length:	533	Species:	Drosophila melanogaster

Alignment Length:	510	Identity:	208/510 - (40%)
Similarity:	313/510 - (61%)	Gaps:	22/510 - (4%)

- Green bases have known domain annotations that are detailed below.

Mouse    36 SHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTITNDGATILSMMDVDHQIAKLMVELSKSQDD 100
            |:|.|||||::.:||||||.|:|||:...:|:|:|||||||||..|:|.|..||::||||::||.
  Fly    29 SNIQAAKAVSDAIRTSLGPRGMDKMIQAGNGEVSITNDGATILKQMNVLHPAAKMLVELSRAQDV 93

Mouse   101 EIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARIAIQHLDKISDKVLVDINNPEPL 165
            ..|||||.|||:||||||..|:||.:|:||..|:|.:::.:..|::.|.::|..  :::::.|.|
  Fly    94 AAGDGTTSVVVIAGALLEACEKLLQKGLHPTAISDSFQRCSNKAVEILKQMSTP--IELDDRETL 156

Mouse   166 IQTAKTTLGSKVINSCHRQMAEIAVNAVLTVADM-ERRDVDFELIKVEGKVGGRLEDTKLIKGVI 229
            |::|.|:|.|||::.....:|.|||:|||.|.|. :...||.:.|||...:||.:|||:|:.|::
  Fly   157 IKSASTSLNSKVVSQQSSLLAPIAVDAVLKVTDPGKETSVDLKNIKVISSLGGTVEDTELVDGLV 221

Mouse   230 VDKDFSHPQMPKKVVDAKIAILTCPFEPPKPKTKHKLDVMSVEDYKALQKYEKEK---FEEMIKQ 291
            .....:....||::..|||.::......||....|.   :.|.||.|:.:..||:   ...::||
  Fly   222 FTCRSAGSNAPKRIEKAKIGLIQFCISAPKTDMDHN---VIVSDYAAMDRVLKEERSYILNIVKQ 283

Mouse   292 IKETGANLAICQWGF-----DDEANHLLLQNGLPAVRWVGGPEIELIAIATGGRIVPRFSELTSE 351
            ||::|.|:.:.|...     .|.|.|.|.:.....|:.|...:||.:......|.:......|:|
  Fly   284 IKKSGCNVLLVQKSILRDAVSDLAQHFLDKIKCMVVKDVEREDIEFVCKTLHCRPIASLDHFTAE 348

Mouse   352 KLGFAGVVQEISFGTTKDKMLVIEKCKN-SRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRD 415
            .|..|.:|:|::.||  :|.:.|...:| .|.|:|..||.||:::|||.|||||||||:|.|::.
  Fly   349 NLSSADLVEEVASGT--NKFVKITGIQNMGRTVSIICRGSNKLVLEEAARSLHDALCVVRCLVKL 411

Mouse   416 NRVVYGGGAAEISCALAVSQEADKCPTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRAR 480
            ...:.||||.||..||.::..|.....::.|..|||||||||||..|:||:|:|||.|:||:|.|
  Fly   412 RAQIVGGGAPEIEMALQLAALAQTVEGVDAYCFRAFADALEVIPSTLAENAGLNPIATVTELRNR 476

Mouse   481 QVK-ESNPALGIDCLHKGS-NDMQYQHVIETLIGKKQQISLATQMVRMILKIDDI 533
            ..: |.|..:.:   .||: .|:..::|::.|:.....|:|||:.:|.|||||||
  Fly   477 HAQGEKNAGINV---RKGAITDIFAENVVQPLLVSISSITLATETIRSILKIDDI 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cct5	NP_031663.1	TCP1_epsilon	10..535	CDD:239455	208/510 (41%)
Cct5	NP_031663.1	Cpn60_TCP1	44..533	CDD:278544	200/500 (40%)
CCT4	NP_609579.1	TCP1_delta	18..531	CDD:239454	208/510 (41%)
CCT4	NP_609579.1	Cpn60_TCP1	37..529	CDD:278544	202/502 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60896
OrthoDB	1	1.010	-	-		D207515at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.830