DRSC/TRiP Functional Genomics Resources

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Protein Alignment MSI2 and Rb97D

DIOPT Version :10

Sequence 1:XP_005257072.1 Gene:MSI2 / 124540 HGNCID:18585 Length:346 Species:Homo sapiens
Sequence 2:NP_524520.1 Gene:Rb97D / 43231 FlyBaseID:FBgn0004903 Length:471 Species:Drosophila melanogaster


Alignment Length:383 Identity:116/383 - (30%)
Similarity:155/383 - (40%) Gaps:77/383 - (20%)


- Green bases have known domain annotations that are detailed below.


Human    22 KMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVDKVLGQPHHEL 86
            |:|||||:..|:.::|:.::.::|::.:.:||||..|||||||||:|:.....||:......|.:
  Fly    33 KLFIGGLAPYTTEENLKLFYGQWGKVVDVVVMRDAATKRSRGFGFITYTKSLMVDRAQENRPHII 97

Human    87 DSKTIDPKVAFPRRAQPKMVTR--TKKIFVGGLSANTVVEDVKQYFEQFGKVEDAMLMFDKTTNR 149
            |.||::.|.|.||..:....|.  .||:|||||..|...|.:::||.|||.|....|:.||||.:
  Fly    98 DGKTVEAKRALPRPERESRETNISVKKLFVGGLKDNHDEECLREYFLQFGNVVSVKLLTDKTTGK 162

Human   150 HRGFGFVTFENEDVVEKVCEIHFHEINNKMVECKKA----QPKEVMFPPGTRG------------ 198
            .|||.||.|::.|.|:|......|.|....|:.||:    ..||...|.|...            
  Fly   163 RRGFAFVEFDDYDAVDKAILKKQHAIKYVHVDVKKSIYNLDKKEKQQPGGLANAIKPSLNQQQQQ 227

Human   199 ------------------------RARGLPYTMDAFMLGMGMLGYPNFVATYGRGYPGFAPSYGY 239
                                    :|.| ||........|. ...|||  .|....|...|.| |
  Fly   228 QGGGQQPPNGNMQAPSFRPPVPPQQAMG-PYQQQPPPAPMS-APPPNF--NYWGPPPPAMPPY-Y 287

Human   240 QFP-----------------GFPAAAYGPVAAAAVAAARGSVLNSYSAQPNFGAPASPAGSN--- 284
            |.|                 |:.|....|..|....|.:..........|..||...|.|.|   
  Fly   288 QQPPPQQMNGWGPYPPPQQNGWNAPPPPPPGAQQWHANQWGCPPPVQQVPPVGAVPPPMGHNGPP 352

Human   285 PARPGGFPGANSPGPVADLYGPASQDSGVGNYISAASPQPGSGFGHGI-ASIPGCPGK 341
            |..||.:   |.|.||.....|:.|..      |:..|.|...||.|. .:..|.|.|
  Fly   353 PTAPGNW---NMPPPVPGAAPPSHQQQ------SSQQPTPQPNFGTGYQQNYGGGPSK 401

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MSI2XP_005257072.1 RRM1_MSI2 17..109 CDD:410153 34/88 (39%)
RRM2_MSI 111..184 CDD:240769 31/72 (43%)
Rb97DNP_524520.1 RRM2_hnRNPA_like 124..196 CDD:409766 31/71 (44%)
RRM_SF 33..110 CDD:473069 31/76 (41%)

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