Protein Alignment MSI2 and msi

DIOPT Version :10

• Sequence 1: XP_005257072.1
• Gene: MSI2 / 124540
• HGNCID: 18585
• Length: 346
• Species: Homo sapiens
• Sequence 2: NP_733108.2
• Gene: msi / 43087
• FlyBaseID: FBgn0011666
• Length: 634
• Species: Drosophila melanogaster
• Alignment Length: 431
• Identity: 163/431 - (37%)
• Similarity: 211/431 - (48%)
• Gaps: 132/431 - (30%)

Human     4 NGSQGTS------GSANDSQHDPGKMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSR 62
            :||.|.|      ||.:|..  |||:|:||||||||.|.|::||:.||.:.:.::|:||.|:|||
  Fly   182 SGSSGRSTPSLSGGSGSDPA--PGKLFVGGLSWQTSSDKLKEYFNMFGTVTDVLIMKDPVTQRSR 244

Human    63 GFGFVTFADPASVDKVLGQPHHELDSKTIDPKVAFPRRAQPKMVTRTKKIFVGGLSANTVVEDVK 127
            ||||:||.:|.:|:|||..|.|.||.|.||||.|.|:. :|:...:||||||||:|.:|..|:||
  Fly   245 GFGFITFQEPCTVEKVLKVPIHTLDGKKIDPKHATPKN-RPRQANKTKKIFVGGVSQDTSAEEVK 308

Human   128 QYFEQFGKVEDAMLMFDKTTNRHRGFGFVTFENEDVVEKVCEIHFHEINNKMVECKKAQPKEVMF 192
            .||.|||.||:.:::.|:.|.||||||||||||||||::|||||||.|.||.||||||||||.:.
  Fly   309 AYFSQFGPVEETVMLMDQQTKRHRGFGFVTFENEDVVDRVCEIHFHTIKNKKVECKKAQPKEAVT 373

Human   193 P---------------------PGTRGRARGLPYTMDAFMLGMGMLGYPNFV------------- 223
            |                     ||....|||...   |.|..:.||..|..:
  Fly   374 PAAQLLQKRIMLGTLGVQLPTAPGQLIGARGAGV---ATMNPLAMLQNPTQLLQSPAAAAAAQQA 435

Human   224 ----------------------ATYGR---GYP-------GFAPSYGYQFPGFPAAAYG------ 250
                                  |.:|:   .||       .:||   |..|...|.|..
  Fly   436 ALISQNPFQVQNAAAAASIANQAGFGKLLTTYPQTALHSVRYAP---YSIPASAATANAALMQAH 497

Human   251 ---PVAAAA---------------------VAAARGSVLNSYSAQPNFGAPASPAGS-------- 283
               .|||||                     ||||:....:.::|..|   |||.|.|
  Fly   498 QAQSVAAAAHHHQQQQQQQHHHQQQTHNAHVAAAQQQQQSHHNAVSN---PASQAHSAAAAAALA 559

Human   284 -NPARPGGFPGANSPGPVADLYGPASQDSGV--GNYISAAS 321
             |.|...|..||:|       ...|:|.:|:  ||.::||:
  Fly   560 ANAANGAGAAGAHS-------LAAAAQQAGLMAGNPLNAAA 593

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MSI2	XP_005257072.1	RRM1_MSI2	17..109	CDD:410153	48/91 (53%)
		RRM2_MSI	111..184	CDD:240769	49/72 (68%)
msi	NP_733108.2	RRM_SF	204..278	CDD:473069	43/73 (59%)
		RRM2_MSI	292..365	CDD:240769	49/72 (68%)