Protein Alignment MSI2 and Rbp4

DIOPT Version :10

• Sequence 1: XP_005257072.1
• Gene: MSI2 / 124540
• HGNCID: 18585
• Length: 346
• Species: Homo sapiens
• Sequence 2: NP_476935.1
• Gene: Rbp4 / 41668
• FlyBaseID: FBgn0010258
• Length: 428
• Species: Drosophila melanogaster
• Alignment Length: 337
• Identity: 100/337 - (29%)
• Similarity: 148/337 - (43%)
• Gaps: 63/337 - (18%)

Human    22 KMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVDKVLGQPHHEL 86
            |:||||||.||:.::||.:||:||.:.:.:|:|||.:..||||||||:.||.||:.|.....|.:
  Fly    33 KIFIGGLSTQTTVETLRGFFSQFGIVADAVVLRDPVSNHSRGFGFVTYVDPKSVEIVQRARPHTI 97

Human    87 DSKTIDPKVAFPRRAQPK---------------MVTRTKKIFVGGLSANTVVEDVKQYFEQFGKV 136
            |:|.::.|.|.||:...:               ....:|:||:|||........|::||.|||.|
  Fly    98 DNKIVETKHALPRQDFKRGGGVGSVVGSFGCEAGFMNSKRIFLGGLKEYHDENIVREYFSQFGPV 162

Human   137 EDAMLMFDKTTNRHRGFGFVTFENEDVVEKVCEIHFHEINNKMVECKKAQPK---EVMFPPGTRG 198
            ....|:.|:.|.|.|.|||:.|.:....||......|.|...:||.|::..|   ...||..:..
  Fly   163 ASVKLLMDRETGRQRAFGFLEFVDPSSAEKALAPRKHWILQTLVEVKRSTQKADRRFRFPIFSSV 227

Human   199 RARGLPYTMDAFMLGMGMLGYPNFVATYGRGYPGFAPSYGYQFPGFPAAAYGPVAAAAVAAARGS 263
            ||..:|               |.         |..|.||.|..|.     |.|..|.:|... .:
  Fly   228 RAGYIP---------------PQ---------PATADSYNYNNPN-----YNPYLAQSVLPP-SA 262

Human   264 VLNSYSAQPNFGAPASP--------AGSNPARPGGFPGANSPGPVADLYG--PASQDSGVGNYIS 318
            ..|.::   ::..|.:|        |.|.|::.......|..||  |::.  |.:.......:.|
  Fly   263 FTNGWA---HYVIPMAPKPTPGQNMAASLPSQQLAEHSLNGHGP--DMWSSYPKTGIYSAQEWTS 322

Human   319 AASPQPGSGFGH 330
            :...:.|...||
  Fly   323 SKVAEWGPKAGH 334

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MSI2	XP_005257072.1	RRM1_MSI2	17..109	CDD:410153	39/101 (39%)
		RRM2_MSI	111..184	CDD:240769	27/72 (38%)
Rbp4	NP_476935.1	RRM_SF	34..105	CDD:473069	34/70 (49%)
		RRM2_hnRNPA_like	137..209	CDD:409766	27/71 (38%)