Protein Alignment MSI2 and sqd

DIOPT Version :10

• Sequence 1: XP_005257072.1
• Gene: MSI2 / 124540
• HGNCID: 18585
• Length: 346
• Species: Homo sapiens
• Sequence 2: NP_731825.1
• Gene: sqd / 41666
• FlyBaseID: FBgn0263396
• Length: 344
• Species: Drosophila melanogaster
• Alignment Length: 348
• Identity: 119/348 - (34%)
• Similarity: 158/348 - (45%)
• Gaps: 67/348 - (19%)

Human     4 NGSQGTSGSANDS----------QHDPGKMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTT 58
            ||..|.:||.|.|          :.|..|:|:|||||:|:...|||:|.|:|||....|..||.|
  Fly    29 NGDAGAAGSTNGSSDNQSAASGQRDDDRKLFVGGLSWETTEKELRDHFGKYGEIESINVKTDPQT 93

Human    59 KRSRGFGFVTFADPASVDKVLGQPHHELDSKTIDPKVAFPRRAQPKMVTRTKKIFVGGLSANTVV 123
            .|||||.|:.|.:..::|||.....|.::||.:|||         |...|..|||||||:.....
  Fly    94 GRSRGFAFIVFTNTEAIDKVSAADEHIINSKKVDPK---------KAKARHGKIFVGGLTTEISD 149

Human   124 EDVKQYFEQFGKVEDAMLMFDKTTNRHRGFGFVTFENEDVVEKVCEIHFHEINNKMVECKKAQPK 188
            |::|.||.|||.:.:..:.|||..::.:||.|:||::|.||..:.:....:|..|.|:.|:|.||
  Fly   150 EEIKTYFGQFGNIVEVEMPFDKQKSQRKGFCFITFDSEQVVTDLLKTPKQKIAGKEVDVKRATPK 214

Human   189 -EVMFPPGTRGRARGLPYTMDAFMLGM--------GMLGYPNFVATYGRG-YPGFAPSYGYQFPG 243
             |.....|.||..||          ||        |..||.|  ...|:| |.|:...||    |
  Fly   215 PENQMMGGMRGGPRG----------GMRGGRGGYGGRGGYNN--QWDGQGSYGGYGGGYG----G 263

Human   244 FPAAAYGPVAAAAVAAARGSVLNSYSAQPNFGAPASPAGSNPARPGGFPGANSPGPVADLYGPAS 308
            :.|..||...|       |...|.|    ::|......|      |||.|....|.     |..:
  Fly   264 YGAGGYGDYYA-------GGYYNGY----DYGYDGYGYG------GGFEGNGYGGG-----GGGN 306

Human   309 QDSGVGNYISAASPQPGSGFGHG 331
            ...|.|.......|:.|.||..|
  Fly   307 MGGGRGGPRGGGGPKGGGGFNGG 329

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MSI2	XP_005257072.1	RRM1_MSI2	17..109	CDD:410153	38/91 (42%)
		RRM2_MSI	111..184	CDD:240769	28/72 (39%)
sqd	NP_731825.1	RRM1_hnRNPA_hnRNPD_like	58..129	CDD:409763	33/70 (47%)
		RRM2_hnRNPD_like	137..211	CDD:240775	29/73 (40%)