DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment OR4D2 and or5i1

DIOPT Version :9

Sequence 1:	NP_001004707.1	Gene:	OR4D2 / 124538	HGNCID:	8294	Length:	307	Species:	Homo sapiens
Sequence 2:	XP_031762372.1	Gene:	or5i1 / 100492617	XenbaseID:	XB-GENE-6032787	Length:	321	Species:	Xenopus tropicalis

Alignment Length:	308	Identity:	124/308 - (40%)
Similarity:	185/308 - (60%)	Gaps:	8/308 - (2%)

- Green bases have known domain annotations that are detailed below.

Human     5 NLTWVSDFVFLGLSQTRELQRFLFLMFLFVYITTVMGNILIIITVTSDSQLHTPMYFLLRNLAVL 69
            |.:...:|:..|||:..:||..||::||.:||.|::||:.:|:.......|.|||||.|.|.:.|
Frog     7 NHSTTREFILAGLSEIPDLQLLLFIVFLCIYIVTLIGNMFMIVAYKLSPNLQTPMYFFLANFSFL 71

Human    70 DLCFSSVTAPKMLVDLLSEKKTISYQGCMGQIFFFHFLGGAMVFFLSVMAFDRLIAISRPLRYVT 134
            ::|:.|.|.||||....:..||||..||:.|:|||..|||...:.|:.||:||.:||..||.|..
Frog    72 EICYISSTVPKMLSGFTAGHKTISVNGCLVQMFFFLLLGGTECYMLASMAYDRYVAICHPLLYFN 136

Human   135 VMNTQLWVGLVVATWVGGFVHSIVQLALMLPLPFCGPNILDNFYCDVPQVLRLACTDTSLLEFLK 199
            :||....:.|:|.:|:.|.|:|::...|...|.|||...:|:||||||.:|:|||:||.:.|.:.
Frog   137 IMNKGACIRLIVGSWLIGTVNSLIHTVLTFTLTFCGSTRIDHFYCDVPPLLKLACSDTWINETVL 201

Human   200 ISNSGLLDVVWFFLLLMSY-LFILVMLRSHPGEARRKAASTCTTHIIVVSMIFVPSIYLYARPFT 263
            ....|.:.:..|.|.|.|| |.|..:|..|....|.|..|||::|::||.:.:..:.::|.||..
Frog   202 HVMCGCVILGSFLLTLTSYTLIISSILNIHLISGRNKVFSTCSSHVMVVIIFYGSATFMYFRPKL 266

Human   264 PF--PMDKLVSIGHTVMTPMLNPMIYTLRNQDMQAAVRRL-----GRH 304
            .:  ..|:.:||.:.|:.|:|||.||:||||.::.|||:|     |.|
Frog   267 SYGTGQDRFISIMYAVIAPLLNPFIYSLRNQQVKDAVRKLIYIIIGTH 314

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
OR4D2	NP_001004707.1	7tm_4	31..301	CDD:304433	112/272 (41%)
OR4D2	NP_001004707.1	7tm_1	41..287	CDD:278431	98/248 (40%)
or5i1	XP_031762372.1	7tmA_OR	27..296	CDD:320092	108/268 (40%)
		TM helix 1	29..53	CDD:320092	10/23 (43%)
		TM helix 2	62..84	CDD:320092	10/21 (48%)
		TM helix 3	100..122	CDD:320092	9/21 (43%)
		TM helix 4	145..161	CDD:320092	6/15 (40%)
		TM helix 5	198..221	CDD:320092	6/22 (27%)
		TM helix 6	240..262	CDD:320092	6/21 (29%)
		TM helix 7	271..296	CDD:320092	11/24 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910