DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment OR4D2 and LOC100491612

DIOPT Version :9

Sequence 1:	NP_001004707.1	Gene:	OR4D2 / 124538	HGNCID:	8294	Length:	307	Species:	Homo sapiens
Sequence 2:	XP_002937083.3	Gene:	LOC100491612 / 100491612	-ID:	-	Length:	312	Species:	Xenopus tropicalis

Alignment Length:	313	Identity:	120/313 - (38%)
Similarity:	190/313 - (60%)	Gaps:	12/313 - (3%)

- Green bases have known domain annotations that are detailed below.

Human     1 METGNLTWVSDFVFLGLSQTRELQRFLFLMFLFVYITTVMGNILIIITVTSDSQLHTPMYFLLRN 65
            |:..|.|.::.|:..|||:..|:|..||.|||.:||.:::||..||......|:|.|||||.|.|
Frog     1 MDKDNATTMNYFLLSGLSEMSEIQHLLFFMFLIIYIISILGNASIIFAYKCSSELQTPMYFCLIN 65

Human    66 LAVLDLCFSSVTAPKMLVDLLSEKKTISYQGCMGQIFFFHFLGGAMVFFLSVMAFDRLIAISRPL 130
            .:.:::|:.|.|.|.:|:.|::..|.||:.||..|::.|.|.|....|.|:.||:||..||..||
Frog    66 FSFVEMCYVSTTVPNLLLQLITGHKRISFYGCATQMYCFSFFGVTECFILAAMAYDRYNAICNPL 130

Human   131 RYVTVMNTQLWVGLVVATWVGGFVHSIVQLALMLPLPFCGPNILDNFYCDVPQVLRLACTDTSLL 195
            .|..:||.:..:..:..:|:...::|::...|...|||||.|.:|:|:||:|.:|:||||||.:.
Frog   131 LYNIIMNKRTCIIFIAGSWLIASINSLIHTVLTFMLPFCGSNAIDSFFCDMPPLLKLACTDTLVN 195

Human   196 EFLKISNSGLLDVVWFFLLLMSYLFIL-----VMLRSHPGEARRKAASTCTTHIIVVSMIFVPSI 255
            :.......|.:....|.|.::||:.|:     :.|.|    .::||.||||:||..|.:.:||||
Frog   196 QITIFVTGGCIIAGPFILTVISYIQIISTIVSIRLTS----KKKKAFSTCTSHITAVVIFYVPSI 256

Human   256 YLYARPFTPFPM--DKLVSIGHTVMTPMLNPMIYTLRNQDMQAAVRRLGRHRL 306
            .:|.||.:...|  ||:.::.:.|:||:|||.||:|||.|::.|:::: .|:|
Frog   257 CIYFRPKSNQAMIQDKMATVIYAVITPLLNPFIYSLRNNDVKVALKKM-VHKL 308

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
OR4D2	NP_001004707.1	7tm_4	31..301	CDD:304433	106/276 (38%)
OR4D2	NP_001004707.1	7tm_1	41..287	CDD:278431	95/252 (38%)
LOC100491612	XP_002937083.3	7tmA_OR	26..294	CDD:320092	105/271 (39%)
		TM helix 1	27..51	CDD:320092	11/23 (48%)
		TM helix 2	60..82	CDD:320092	8/21 (38%)
		TM helix 3	98..120	CDD:320092	7/21 (33%)
		TM helix 4	143..159	CDD:320092	2/15 (13%)
		TM helix 5	196..219	CDD:320092	4/22 (18%)
		TM helix 6	238..260	CDD:320092	11/21 (52%)
		TM helix 7	269..294	CDD:320092	11/24 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910