Protein Alignment METTL23 and EFM6

DIOPT Version :10

• Sequence 1: NP_001073979.3
• Gene: METTL23 / 124512
• HGNCID: 26988
• Length: 190
• Species: Homo sapiens
• Sequence 2: NP_014374.1
• Gene: EFM6 / 855707
• SGDID: S000004969
• Length: 246
• Species: Saccharomyces cerevisiae
• Alignment Length: 166
• Identity: 40/166 - (24%)
• Similarity: 75/166 - (45%)
• Gaps: 37/166 - (22%)

Human     3 VWPCAVVLAQYL------WFHRRSLPG----KAILEIGAGVSLPGILAAKC-------GAEVILS 50
            ||....:|.:|:      ....:::.|    |.:||:|:|..|.|:.....       |.:|.::
Yeast    50 VWIAGELLCEYILEKSVDHLLSKTVNGTKQFKKVLELGSGTGLVGLCVGLLEKNTFHDGTKVYVT 114

Human    51 DSSELPHCLEVCRQSCQMNNLPHLQVVG--LTWGH-ISWDLLALPPQ---------DIILASDVF 103
            |..:|   :.:.:::.:::.:.: :|:.  |.||. :|.|   ..||         |::||:|..
Yeast   115 DIDKL---IPLLKRNIELDEVQY-EVLARELWWGEPLSAD---FSPQEGAMQANNVDLVLAADCV 172

Human   104 FEPEDFEDILATIYFLMH-KNPKVQLWSTYQVRSAD 138
            :..|.|..:..|:..|.| .||.|.|.:..:.|.||
Yeast   173 YLEEAFPLLEKTLLDLTHCINPPVILMAYKKRRKAD 208

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
METTL23	NP_001073979.3	AdoMet_MTases	3..126	CDD:473071	35/152 (23%)
EFM6	NP_014374.1	Methyltransf_16	33..218	CDD:313513	40/166 (24%)