Protein Alignment METTL23 and W06B4.2

DIOPT Version :10

• Sequence 1: NP_001073979.3
• Gene: METTL23 / 124512
• HGNCID: 26988
• Length: 190
• Species: Homo sapiens
• Sequence 2: NP_494789.1
• Gene: W06B4.2 / 173784
• WormBaseID: WBGene00021057
• Length: 521
• Species: Caenorhabditis elegans
• Alignment Length: 202
• Identity: 62/202 - (30%)
• Similarity: 99/202 - (49%)
• Gaps: 22/202 - (10%)

Human     2 YVWPCAVVLAQYLWFHRRSLPGKAILEIGAGVS-LPGILAAKCG-AEVILSDSSELPHCLEVCRQ 64
            :.||||.|.:.:|..::..:..|.:||||||.: :.|:..||.| |.|.::|..:|...||..::
 Worm    11 HAWPCAQVFSDFLCSNQELIEDKLVLEIGAGATGVCGLTTAKLGAANVWMTDHPKLEAALETLQR 75

Human    65 SCQMNNLPHLQVV-GLTW---GHIS--WDLLALPPQDIILASDVFFEPEDFEDILATIYFLMHKN 123
            :.:.|.:....:| ||.|   ..:|  .|.:.....|:|:||||||:|..|..::.|...|:.|.
 Worm    76 NIEANGVAEKCIVTGLDWESRASVSAVCDQIGDRHLDVIIASDVFFDPSTFCPLIDTFAQLLIKF 140

Human   124 PKVQLWSTYQVRSADWSLEALLYKWDMKCVHIPLE-SFDADKE--DIAEST---------LPGRH 176
            ....:|..||:|..:|:....|.|:..  :...|| ..:.:||  ||.:.|         :.|..
 Worm   141 EHATIWFAYQLRDDNWTCAPYLSKYPF--LRATLERRIETEKETIDIFKMTRESLGLYAGIEGGA 203

Human   177 TVEMLVI 183
            |...|||
 Worm   204 TGSKLVI 210

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
METTL23	NP_001073979.3	AdoMet_MTases	3..126	CDD:473071	43/130 (33%)
W06B4.2	NP_494789.1	Nnt1	<8..190	CDD:443104	56/180 (31%)
		ASKHA_NBD_NAGK_meta	195..501	CDD:466928	5/16 (31%)