Protein Alignment ANKS3 and mlt-3

DIOPT Version :9

• Sequence 1: XP_011520674.1
• Gene: ANKS3 / 124401
• HGNCID: 29422
• Length: 668
• Species: Homo sapiens
• Sequence 2: NP_502319.2
• Gene: mlt-3 / 189743
• WormBaseID: WBGene00012704
• Length: 392
• Species: Caenorhabditis elegans
• Alignment Length: 553
• Identity: 116/553 - (20%)
• Similarity: 185/553 - (33%)
• Gaps: 207/553 - (37%)

Human    47 VPLDLHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVPT 111
            |.:|..||||||....:||.::.....:..||..|||||:||:|:||:::...||:.|..|:..|
 Worm    45 VLMDACTAASIGDENKLKELMKINPNTMIMKNHDGWTPLLYAAYLGHNSVAAFLLDNGAKVDDST 109

Human   112 -PEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSGANANV 175
             ...|||||:||:|||.|:...||.:||...:.|.:...|:.:.:|.....:|..||.:|.:.|.
 Worm   110 ESRWQTPLMMASACGNISVVRLLLGRGANPRLCDKEKRQAIHYASSCCQNVVVDTLLAAGCDPNA 174

Human   176 REPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIVALMDTYSPSL 240
            .:.. |.||:.|||.|||||.....|..|..::.::..|..|..||  ..:.||:.|
 Worm   175 ADSE-GTTPVHEAAMAGHEITFIALLEKGGNLELKNAKGENAAALA--CDNNKILQL-------- 228

Human   241 PKSLYRSPEKYEDLSSSDESCPAPQRQRPCRKKGVSIHEGPRALARITGIGLGGRAPRPRYEQAP 305
                                                                             
 Worm   229 ----------------------------------------------------------------- 228

Human   306 PRGYVTFNSSGENPLEEEGLCCRDVTSPINERDVESSSSSSSREEHAFCANLGPVQSSSSSEGLA 370
                                        |:|...|.:..||
 Worm   229 ----------------------------ISEHQAEIAKQSS------------------------ 241

Human   371 RAQGLSSEASVESNEDSDHACKSSARKQAKSYMKTKNPDSQWPPRAATDREGFLAESSPQTQRAP 435
                                             ||.|
 Worm   242 ---------------------------------KTGN---------------------------- 245

Human   436 YSGPQDLAALLEQIGCLKYLQVFEEQDVDLRIFLTLTESDLKEIGITLFGPKRKMTSAIARWHSS 500
             .||:.|:.|||::...:|:..|:.::|||.:|..|.|.|..::.|. :|||::|...|.|:..:
 Worm   246 -RGPRRLSELLEEMDLSRYIDQFKHENVDLEVFFELKEQDFVDMNIA-YGPKKRMLDVIERYKKT 308

Human   501 ARPPGDALELAYADRLEAEMQELAIQLHKRCEEVEATRGQVCQ-EQELRAVVESCLLEQDRARED 564
            .....||.:....    ..|........:..|:..||...:.: .||.:..|.:.|......::.
 Worm   309 GVIRSDAFDAPQG----TAMSTKGSSTRESSEKTTATLKSIKELNQETKKSVMTALESLGSGQDK 369

Human   565 LQARLRETWALARDAALVLDQLRACQAELSSRV 597
            ::|:|          ..:|:.:.....::||.|
 Worm   370 VRAQL----------ISILNNVETISLKVSSHV 392

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ANKS3	XP_011520674.1	Ank_2	51..144	CDD:289560	40/93 (43%)
		ANK repeat	51..78	CDD:293786	8/26 (31%)
		ANK	75..201	CDD:238125	51/126 (40%)
		ANK repeat	81..111	CDD:293786	14/29 (48%)
		ANK repeat	113..144	CDD:293786	15/30 (50%)
		Ank_2	118..211	CDD:289560	33/92 (36%)
		ANK repeat	146..176	CDD:293786	7/29 (24%)
		ANK repeat	180..211	CDD:293786	13/30 (43%)
		SAM	434..494	CDD:197735	20/59 (34%)
		SAM_ANKS3	436..499	CDD:188918	22/62 (35%)
mlt-3	NP_502319.2	ANKYR	46..234	CDD:223738	71/291 (24%)
		ANK repeat	78..109	CDD:293786	14/30 (47%)
		ANK repeat	111..176	CDD:293786	23/64 (36%)
		ANK repeat	178..209	CDD:293786	13/31 (42%)
		SAM_1	247..306	CDD:366155	22/59 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161472381
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BIET
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12475
Inparanoid	1	1.050	165	1.000	Inparanoid score	I3216
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D422790at33208
OrthoFinder	1	1.000	-	-		FOG0009798
OrthoInspector	1	1.000	-	-		oto23697
orthoMCL	1	0.900	-	-		OOG6_111659
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4377
SonicParanoid	1	1.000	-	-		X6392
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.690