DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ANKS3 and anks3

DIOPT Version :9

Sequence 1:	XP_011520674.1	Gene:	ANKS3 / 124401	HGNCID:	29422	Length:	668	Species:	Homo sapiens
Sequence 2:	XP_002932472.1	Gene:	anks3 / 100380077	XenbaseID:	XB-GENE-999239	Length:	635	Species:	Xenopus tropicalis

Alignment Length:	663	Identity:	390/663 - (58%)
Similarity:	489/663 - (73%)	Gaps:	41/663 - (6%)

- Green bases have known domain annotations that are detailed below.

Human    13 MSELSDEASEPELLNRSLSMWHGLGTQVSGEELDVPLDLHTAASIGQYEVVKECVQRRELDLNKK 77
            |:||||||||.|:|:||||:|:|    ...::.::||||||||||||||||:.|::||.:|||::
Frog     1 MAELSDEASETEMLSRSLSIWYG----EPHDDEELPLDLHTAASIGQYEVVQHCMRRRGVDLNQQ 61

Human    78 NGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEM 142
            |.|||||||||||||||.:|.|||||||.||..||.|||||:||:||||||:||||||||||||.
Frog    62 NLGGWTPLMYASYIGHDAVVSLLLEAGVDVNCRTPSGQTPLILAASCGNESVAYFLLQQGAELEA 126

Human   143 KDIQGWTALFHCTSAGHQHMVRFLLDSGANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKV 207
            :|.:||||||||||||||.|:||||::|||.:||||:.||||||||||:|||||||:.|||||||
Frog   127 RDSRGWTALFHCTSAGHQRMLRFLLENGANGDVREPLYGFTPLMEAAASGHEIIVQHLLNHGVKV 191

Human   208 DARDHSGATARMLAKQYGHMKIVALMDTYSPSLPKSLYR-SPEKYEDLSSSDESCPAPQRQRPCR 271
            ...|.:|.||||||.::||.:||:|:|::.|...::..| |..::|||||||||..||||.||.|
Frog   192 AETDRNGDTARMLAARFGHSRIVSLLDSHRPRGSRTHSRGSAVRHEDLSSSDESTSAPQRSRPQR 256

Human   272 K-KGVSIHEGPRALARITGIGLGGRAPRPRYEQAPPRGYVTFNSSGENPLEEEGLCCRDVTSPIN 335
            | ||.|||:||:|||::|| |.||        ..||:|||||  ||::...:|.||.||||||||
Frog   257 KPKGPSIHDGPQALAKMTG-GGGG--------NVPPKGYVTF--SGQDAAGDEDLCYRDVTSPIN 310

Human   336 ERDVESSSSSSSREEHAFCANLGPVQSSSSSEGLARAQGLSSEASVESNEDSDHACKSSARKQAK 400
            |.||||:.||...::.      |.:| ||||||......:|||||:|||||||.| ::::||.:|
Frog   311 EHDVESNGSSRDEDDS------GRLQ-SSSSEGPCPNPDVSSEASLESNEDSDSA-ETTSRKPSK 367

Human   401 SYMKTK--NPDSQWPPRAATDREGFLAESSPQTQRAPYSGPQDLAALLEQIGCLKYLQVFEEQDV 463
            ...|.|  |.|:|..|..:..|   .:.|....:...|:||:|||.:||||||||||.|||||||
Frog   368 PLAKGKQRNGDTQTFPGGSDCR---FSNSLLNLEAPAYTGPKDLAEMLEQIGCLKYLPVFEEQDV 429

Human   464 DLRIFLTLTESDLKEIGITLFGPKRKMTSAIARWHSSARPPGDALELAYADRLEAEMQELAIQLH 528
            :|||||||||:||:|:||:|||||||||||||||||||||||||||.||||||||||||||||||
Frog   430 NLRIFLTLTETDLREVGISLFGPKRKMTSAIARWHSSARPPGDALEQAYADRLEAEMQELAIQLH 494

Human   529 KRCEEVEATRGQVCQEQELRAVVESCLLEQDRAREDLQARLRETWALARDAALVLDQLRACQAEL 593
            |:|||.|..:.||.||:|||.|.||||:||:......:.:|..|...|.||...:.|||:||.||
Frog   495 KKCEETELLKAQVAQERELRTVAESCLMEQESQWRTFRCQLETTGTHANDAQRAITQLRSCQQEL 559

Human   594 SSRVRQDQPPGAATLGLAVPPADSKGWQ----ASLQAMSLPELSGALEDRVREMGQALCLVTQSL 654
            |.|:.:...|  .|.|   ||..:.|.:    ||:::||:.|||.:||:....:|::...|.::|
Frog   560 SHRLGKVTAP--RTRG---PPGRTAGLEGISTASVKSMSMVELSTSLEEIAATLGKSTRAVQENL 619

Human   655 EKLQVLN-GK-KW 665
            |||::.: |: ||
Frog   620 EKLRMPDKGRHKW 632

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ANKS3	XP_011520674.1	Ank_2	51..144	CDD:289560	72/92 (78%)
		ANK repeat	51..78	CDD:293786	19/26 (73%)
		ANK	75..201	CDD:238125	98/125 (78%)
		ANK repeat	81..111	CDD:293786	24/29 (83%)
		ANK repeat	113..144	CDD:293786	25/30 (83%)
		Ank_2	118..211	CDD:289560	72/92 (78%)
		ANK repeat	146..176	CDD:293786	22/29 (76%)
		ANK repeat	180..211	CDD:293786	24/30 (80%)
		SAM	434..494	CDD:197735	47/59 (80%)
		SAM_ANKS3	436..499	CDD:188918	52/62 (84%)
anks3	XP_002932472.1	ANKYR	30..188	CDD:223738	121/157 (77%)
		ANK repeat	35..62	CDD:293786	19/26 (73%)
		ANK repeat	65..95	CDD:293786	24/29 (83%)
		ANK repeat	97..128	CDD:293786	25/30 (83%)
		ANK repeat	130..160	CDD:293786	22/29 (76%)
		ANK repeat	164..189	CDD:293786	20/24 (83%)
		Ank_4	167..217	CDD:372654	34/49 (69%)
		PHA03307	195..>368	CDD:223039	99/191 (52%)
		SAM_ANKS3	402..465	CDD:188918	52/62 (84%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	146	1.000	Domainoid score	I21803
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H12475
Inparanoid	1	1.050	694	1.000	Inparanoid score	I5407
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D129880at7742
OrthoFinder	1	1.000	-	-		FOG0009798
OrthoInspector	1	1.000	-	-		oto155421
Panther	1	1.100	-	-	LDO	PTHR24184
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6392
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.160