Protein Alignment ANKS3 and anks3

DIOPT Version :10

• Sequence 1: XP_011520674.1
• Gene: ANKS3 / 124401
• HGNCID: 29422
• Length: 668
• Species: Homo sapiens
• Sequence 2: XP_002932472.1
• Gene: anks3 / 100380077
• XenbaseID: XB-GENE-999239
• Length: 635
• Species: Xenopus tropicalis
• Alignment Length: 663
• Identity: 390/663 - (58%)
• Similarity: 489/663 - (73%)
• Gaps: 41/663 - (6%)

Human    13 MSELSDEASEPELLNRSLSMWHGLGTQVSGEELDVPLDLHTAASIGQYEVVKECVQRRELDLNKK 77
            |:||||||||.|:|:||||:|:|    ...::.::||||||||||||||||:.|::||.:|||::
 Frog     1 MAELSDEASETEMLSRSLSIWYG----EPHDDEELPLDLHTAASIGQYEVVQHCMRRRGVDLNQQ 61

Human    78 NGGGWTPLMYASYIGHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEM 142
            |.|||||||||||||||.:|.|||||||.||..||.|||||:||:||||||:||||||||||||.
 Frog    62 NLGGWTPLMYASYIGHDAVVSLLLEAGVDVNCRTPSGQTPLILAASCGNESVAYFLLQQGAELEA 126

Human   143 KDIQGWTALFHCTSAGHQHMVRFLLDSGANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKV 207
            :|.:||||||||||||||.|:||||::|||.:||||:.||||||||||:|||||||:.|||||||
 Frog   127 RDSRGWTALFHCTSAGHQRMLRFLLENGANGDVREPLYGFTPLMEAAASGHEIIVQHLLNHGVKV 191

Human   208 DARDHSGATARMLAKQYGHMKIVALMDTYSPSLPKSLYR-SPEKYEDLSSSDESCPAPQRQRPCR 271
            ...|.:|.||||||.::||.:||:|:|::.|...::..| |..::|||||||||..||||.||.|
 Frog   192 AETDRNGDTARMLAARFGHSRIVSLLDSHRPRGSRTHSRGSAVRHEDLSSSDESTSAPQRSRPQR 256

Human   272 K-KGVSIHEGPRALARITGIGLGGRAPRPRYEQAPPRGYVTFNSSGENPLEEEGLCCRDVTSPIN 335
            | ||.|||:||:|||::|| |.||        ..||:|||||  ||::...:|.||.||||||||
 Frog   257 KPKGPSIHDGPQALAKMTG-GGGG--------NVPPKGYVTF--SGQDAAGDEDLCYRDVTSPIN 310

Human   336 ERDVESSSSSSSREEHAFCANLGPVQSSSSSEGLARAQGLSSEASVESNEDSDHACKSSARKQAK 400
            |.||||:.||...::.      |.:| ||||||......:|||||:|||||||.| ::::||.:|
 Frog   311 EHDVESNGSSRDEDDS------GRLQ-SSSSEGPCPNPDVSSEASLESNEDSDSA-ETTSRKPSK 367

Human   401 SYMKTK--NPDSQWPPRAATDREGFLAESSPQTQRAPYSGPQDLAALLEQIGCLKYLQVFEEQDV 463
            ...|.|  |.|:|..|..:..|   .:.|....:...|:||:|||.:||||||||||.|||||||
 Frog   368 PLAKGKQRNGDTQTFPGGSDCR---FSNSLLNLEAPAYTGPKDLAEMLEQIGCLKYLPVFEEQDV 429

Human   464 DLRIFLTLTESDLKEIGITLFGPKRKMTSAIARWHSSARPPGDALELAYADRLEAEMQELAIQLH 528
            :|||||||||:||:|:||:|||||||||||||||||||||||||||.||||||||||||||||||
 Frog   430 NLRIFLTLTETDLREVGISLFGPKRKMTSAIARWHSSARPPGDALEQAYADRLEAEMQELAIQLH 494

Human   529 KRCEEVEATRGQVCQEQELRAVVESCLLEQDRAREDLQARLRETWALARDAALVLDQLRACQAEL 593
            |:|||.|..:.||.||:|||.|.||||:||:......:.:|..|...|.||...:.|||:||.||
 Frog   495 KKCEETELLKAQVAQERELRTVAESCLMEQESQWRTFRCQLETTGTHANDAQRAITQLRSCQQEL 559

Human   594 SSRVRQDQPPGAATLGLAVPPADSKGWQ----ASLQAMSLPELSGALEDRVREMGQALCLVTQSL 654
            |.|:.:...|  .|.|   ||..:.|.:    ||:::||:.|||.:||:....:|::...|.::|
 Frog   560 SHRLGKVTAP--RTRG---PPGRTAGLEGISTASVKSMSMVELSTSLEEIAATLGKSTRAVQENL 619

Human   655 EKLQVLN-GK-KW 665
            |||::.: |: ||
 Frog   620 EKLRMPDKGRHKW 632

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ANKS3	XP_011520674.1	ANKYR	50..232	CDD:440430	136/181 (75%)
		ANK repeat	51..78	CDD:293786	19/26 (73%)
		ANK repeat	81..111	CDD:293786	24/29 (83%)
		ANK repeat	113..144	CDD:293786	25/30 (83%)
		ANK repeat	146..176	CDD:293786	22/29 (76%)
		ANK repeat	180..211	CDD:293786	24/30 (80%)
		SAM_ANKS3	436..499	CDD:188918	52/62 (84%)
anks3	XP_002932472.1	ANKYR	<27..217	CDD:440430	138/189 (73%)
		ANK repeat	35..62	CDD:293786	19/26 (73%)
		ANK repeat	65..95	CDD:293786	24/29 (83%)
		ANK repeat	97..128	CDD:293786	25/30 (83%)
		ANK repeat	130..160	CDD:293786	22/29 (76%)
		ANK repeat	164..189	CDD:293786	20/24 (83%)
		PHA03307	195..>368	CDD:223039	99/191 (52%)
		SAM_ANKS3	402..465	CDD:188918	52/62 (84%)