DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CDYL2 and swi6

DIOPT Version :9

Sequence 1:	XP_011521168.1	Gene:	CDYL2 / 124359	HGNCID:	23030	Length:	540	Species:	Homo sapiens
Sequence 2:	NP_593449.1	Gene:	swi6 / 2541633	PomBaseID:	SPAC664.01c	Length:	328	Species:	Schizosaccharomyces pombe

Alignment Length:	265	Identity:	62/265 - (23%)
Similarity:	95/265 - (35%)	Gaps:	82/265 - (30%)

- Green bases have known domain annotations that are detailed below.

Human    41 EEVERIVDK-----RKNKKGKWEYLIRWKGYGSTED-TWEPEHHLLHCEEFIDEFNGLH-----M 94
            ||.|.:|:|     ...|.|.:|||::|:||....| ||..|.....|::.|:.:...|     .
pombe    77 EEDEYVVEKVLKHRMARKGGGYEYLLKWEGYDDPSDNTWSSEADCSGCKQLIEAYWNEHGGRPEP 141

Human    95 SKDKRIKSGKQSSTSKLLRDSRGPSVEKLSHRPSDPGK-SKGTSHKRKRIN-------------- 144
            ||.||....|:.       :::.||.:.   |.:|..| .|.::.|.:.:|
pombe   142 SKRKRTARPKKP-------EAKEPSPKS---RKTDEDKHDKDSNEKIEDVNEKTIKFADKSQEEF 196

Human   145 ----PPLAKPKKGY------SGKPSSGGDRATKTVSYRTTPSGLQIMPLKK-------------- 185
                ||..:| .|:      |..||......::.:....|||  .:.|.||
pombe   197 NENGPPSGQP-NGHIESDNESKSPSQKESNESEDIQIAETPS--NVTPKKKPSPEVPKLPDNREL 258

Human   186 ----------------SQNGMENGDAGSEKDERHFGNG--SHQPGLDLNDHVGEQDMGECDVNHA 232
                            |.:.:|..|.|:.:....:.||  ||.|....|... .|.|.:...:|.
pombe   259 TVKQVENYDSWEDLVSSIDTIERKDDGTLEIYLTWKNGAISHHPSTITNKKC-PQKMLQFYESHL 322

Human   233 TLAEN 237
            |..||
pombe   323 TFREN 327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CDYL2	XP_011521168.1	CHROMO	40..89	CDD:214605	19/53 (36%)
CDYL2	XP_011521168.1	crotonase-like	286..482	CDD:119339
swi6	NP_593449.1	CHROMO	85..134	CDD:237991	15/48 (31%)
swi6	NP_593449.1	ChSh	261..326	CDD:197638	14/65 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1911
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810