DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cbx2 and HP1b

DIOPT Version :9

Sequence 1:	XP_006532166.1	Gene:	Cbx2 / 12416	MGIID:	88289	Length:	594	Species:	Mus musculus
Sequence 2:	NP_001162713.1	Gene:	HP1b / 31834	FlyBaseID:	FBgn0030082	Length:	240	Species:	Drosophila melanogaster

Alignment Length:	280	Identity:	55/280 - (19%)
Similarity:	82/280 - (29%)	Gaps:	112/280 - (40%)

- Green bases have known domain annotations that are detailed below.

Mouse   289 ALKAHTKEACGGPSTMATPENLASLMKGMAGSPSRGGIWQSSIVHYMNRMSQSQVQAASRLALKA 353
            :||.:.||.....||.:|||::.|..|......:..   |..::.:...:..|::..|
  Fly    53 SLKNNKKETKKRLSTSSTPESIRSKRKSFLEDDTEE---QKKLIGFERGLEASKILGA------- 107

Mouse   354 QATNKCGLGLDLKVRTQKGGEL------GGSPAGGKVPKAPGGGAAEQQRGNHSGSPGAQLAPTQ 412
                           |...|.|      .||.....||                    |:||.|:
  Fly   108 ---------------TDSSGHLMFLMKWKGSDHADLVP--------------------AKLANTR 137

Mouse   413 --ELSLQVLDLQSVKNGVPGVGLLARHAPAKAIPATNPATGKGPGSGPTGANMTNAPTDNNKGEK 475
              ::.:|..:.:           |..|            ||.|.|:|.|  |..|..:....|
  Fly   138 CPQVVIQFYEER-----------LTWH------------TGSGNGNGNT--NSVNLGSSGGLG-- 175

Mouse   476 LTCKATALPAPSVKRDTVKSVAASGGQEGHTAPGEGRKPPALSELSTGEENSSSDSDPDSTSLPS 540
                               ||..||..: .||||           |.|.....|:.|......|.
  Fly   176 -------------------SVGGSGAGD-DTAPG-----------SVGTTGGGSNIDGGDEEDPE 209

Mouse   541 AAQNLSVAIQTSQDWKPTRS 560
            .|..:. :|...::.||..|
  Fly   210 PASPIG-SINQDENIKPDES 228

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cbx2	XP_006532166.1	CBX7_C	553..585	CDD:375056	3/8 (38%)
HP1b	NP_001162713.1	CHROMO	3..52	CDD:214605
HP1b	NP_001162713.1	Chromo_shadow	100..151	CDD:279701	14/103 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1628171at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920