Protein Alignment ADH1A and Fdh

DIOPT Version :10

• Sequence 1: NP_000658.1
• Gene: ADH1A / 124
• HGNCID: 249
• Length: 375
• Species: Homo sapiens
• Sequence 2: NP_524310.1
• Gene: Fdh / 41311
• FlyBaseID: FBgn0011768
• Length: 379
• Species: Drosophila melanogaster
• Alignment Length: 377
• Identity: 202/377 - (53%)
• Similarity: 267/377 - (70%)
• Gaps: 3/377 - (0%)

Human     2 STAGKVIKCKAAVLWELKKPFSIEEVEVAPPKAHEVRIKMVAVGICGTDDHVVSGTMVTPL-PVI 65
            :|.||||.|||||.||.|||..||::|||||||||||||:.|.|:|.||...:||.....| ||:
  Fly     3 ATEGKVITCKAAVAWEAKKPLVIEDIEVAPPKAHEVRIKITATGVCHTDAFTLSGADPEGLFPVV 67

Human    66 LGHEAAGIVESVGEGVTTVKPGDKVIPLAIPQCGKCRICKNPESNYCLKNDVSNPQGTLQDGTSR 130
            ||||.||||||||||||..|.||.||.|.||||.:|:.||:.::|.|.|..::...|.:.:||||
  Fly    68 LGHEGAGIVESVGEGVTNFKAGDHVIALYIPQCNECKFCKSGKTNLCQKIRLTQGAGVMPEGTSR 132

Human   131 FTCRRKPIHHFLGISTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVNVAKVTPGST 195
            .:|:.:.:.||:|.|||::||||.:.::.||:..:|||||||:|||.|||||:|:|.|||..|||
  Fly   133 LSCKGQQLFHFMGTSTFAEYTVVADISLTKINEKAPLEKVCLLGCGISTGYGAALNTAKVEAGST 197

Human   196 CAVFGLGGVGLSAIMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDY--KKPIQEVLKEM 258
            |||:|||.|||:..:|||.|||.:|..:|||.|||..||:.|.|:.:||:|.  |..||..|.::
  Fly   198 CAVWGLGAVGLAVGLGCKKAGAGKIYGIDINPDKFELAKKFGFTDFVNPKDVADKGSIQNYLIDL 262

Human   259 TDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPDSQNLSMNPMLLLTGRTWKGAILGGF 323
            ||||.|::||.||.::||.::|...|:..||||::||....|.:|..|..|:.||.|||:..||:
  Fly   263 TDGGFDYTFECIGNVNTMRSALEATHKGWGTSVVIGVAGAGQEISTRPFQLVVGRVWKGSAFGGW 327

Human   324 KSKECVPKLVADFMAKKFSLDALITHVLPFEKINEGFDLLHSGKSIRTILMF 375
            :|...|||||.|::.|...:|..|||.||..:|||.|||:|.|:|||:|:.:
  Fly   328 RSVSDVPKLVEDYLKKDLLVDEFITHELPLSQINEAFDLMHKGESIRSIIKY 379

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ADH1A	NP_000658.1	alcohol_DH_class_I_II_IV	3..375	CDD:176259	202/374 (54%)
Fdh	NP_524310.1	alcohol_DH_class_III	9..378	CDD:176260	198/368 (54%)