Protein Alignment ADH1A and Drat

DIOPT Version :10

• Sequence 1: NP_000658.1
• Gene: ADH1A / 124
• HGNCID: 249
• Length: 375
• Species: Homo sapiens
• Sequence 2: NP_610293.3
• Gene: Drat / 35687
• FlyBaseID: FBgn0033188
• Length: 434
• Species: Drosophila melanogaster
• Alignment Length: 384
• Identity: 68/384 - (17%)
• Similarity: 116/384 - (30%)
• Gaps: 142/384 - (36%)

Human    27 VEVAPPKAHEVRIKMVAVGICG---------TDDHVVSGTMVTPLPVI----------------- 65
            |.:....|...||::|..|.|.         |....||..:....|.:
  Fly    79 VPIEDTPALGARIRIVCAGACYRRRDRANSITSMSSVSSELSDYCPSVNSMSSPAHQGIREGSFF 143

Human    66 LGHEAAGIVESVGEGVTT-----VKPGDKVI--PLAIPQCGKCRICKNPESNYCLKNDVSNPQGT 123
            .|.|.||::||:|..:|.     ::.|.:||  |......|...:...|:    ||:.|..|
  Fly   144 PGFEVAGVIESLGSEITEANNRGLRIGQRVIVYPFDETPAGYAELLVVPD----LKHVVPIP--- 201

Human   124 LQDGTSRFTCRRKPIHHFLGISTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVNVA 188
              |..........|....|..:...:...|....:::..|..|..|..::
  Fly   202 --DSLPMEVAAMLPTGALLAWNAVFKAQAVVTQILSQRAATEPKRKPKIL--------------- 249

Human   189 KVTPGSTCAVFGLGGVGLSAI------MGCKAAGAARIIAVDINKDKFAKAKELGA------TEC 241
                     :.|.||:.|.|:      .....|....|....:..:.|..|.|:..      .||
  Fly   250 ---------IVGTGGLALWAVRIASYHFATTGADNVDITVASLRDEGFRLATEIKNVSVVQWNEC 305

Human   242 INPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPDSQNLSMNP 306
            :    |:..:.|..|::..|.||                          |::.....|::|
  Fly   306 L----YEPQLIERTKDVCGGAVD--------------------------VVIDFGTTSRSL---- 336

Human   307 MLLLTGRTWKGAILGGFKSKECVPK----LVADFMAKKFSLDALITHVLP-FEKINEGF 360
                            .:|..|:.|    |::|.:|:|         :|| |.:::|.:
  Fly   337 ----------------HRSMHCLSKGGVVLISDEVAEK---------LLPKFSRLSEQY 370

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ADH1A	NP_000658.1	alcohol_DH_class_I_II_IV	3..375	CDD:176259	68/384 (18%)
Drat	NP_610293.3	MDR	144..428	CDD:450120	57/319 (18%)