Protein Alignment Runx1 and RunxA

DIOPT Version :9

• Sequence 1: NP_001104491.1
• Gene: Runx1 / 12394
• MGIID: 99852
• Length: 465
• Species: Mus musculus
• Sequence 2: NP_001259747.1
• Gene: RunxA / 4379817
• FlyBaseID: FBgn0083981
• Length: 663
• Species: Drosophila melanogaster
• Alignment Length: 475
• Identity: 175/475 - (36%)
• Similarity: 220/475 - (46%)
• Gaps: 134/475 - (28%)

Mouse    22 STSRRFTPPSTALSPGKMSEALPLGAPDGGAALASKLRS---GDRSMVEVLADHPGELVRTDSPN 83
            |.:.:.|||:.|   ..::||.            :|:.|   .:|::.:.|.:|||||:||.||.
  Fly    57 SNTEQNTPPTPA---QLLNEAY------------TKMTSDILAERTLGDFLTEHPGELIRTSSPL 106

Mouse    84 FLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDL 148
            |:|:|||.|||.|||||:|||||:|||:.|||:|||.|||||||.|||||.||.||||||:||||
  Fly   107 FVCTVLPPHWRSNKTLPVAFKVVSLGDIMDGTMVTVRAGNDENYCAELRNCTAVMKNQVAKFNDL 171

Mouse   149 RFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPR-RHRQKLDDQTKPGSLSFSERL 212
            ||||||||||||||||||.||||.:|||::|||:||||||||| :....|..|.:....:|.:|
  Fly   172 RFVGRSGRGKSFTLTITVSTNPPHIATYNKAIKVTVDGPREPRSKTMLSLLGQQQQFHFAFGQR- 235

Mouse   213 SELEQLRRTAMRVSPHHPAPTPNPRASLNHSTAFNPQPQSQMQDARQIQPSPPWSYDQSYQ---- 273
                          |.|.:..|        .:.|...|....|.|....    |.|..:..
  Fly   236 --------------PFHFSTDP--------LSGFRMPPIGNCQSASNTH----WGYGSAASAYSP 274

Mouse   274 YLGSITSSSVHPATPISP---GRASGMTSLSAELSSRL----------------STAPDLTAFGD 319
            ||.|...||.  .||.|.   ..|.|.|..|.:.|:..                |||.||    |
  Fly   275 YLASSGLSSC--TTPTSAQFNNPALGFTCSSNDQSNNQDFGGATNRDCVPMLPDSTASDL----D 333

Mouse   320 PRQFPTLPSISDPRMHY-----------------------PGAFTYSPPVTSGIGIGMSAMSSA- 360
            ......:.|.|....|:                       .||.|......||.|.|..|..::
  Fly   334 QHLSSLVGSTSGQMTHHSLLGAGGQTSISSTVNGASGGGSAGAGTAGGGAGSGGGAGGGAGGNSI 398

Mouse   361 --SRYHTYL------------PPPYPGSSQAQAGPFQ-----TGSPSYHLYYGASAGSYQFSMVG 406
              .||||..            |.....||||:: |.|     |.:|:    .|::||....:  |
  Fly   399 LVPRYHTNASNEYNVHSSQNGPRSLSDSSQAES-PVQEDLLTTNTPN----LGSTAGGGAAN--G 456

Mouse   407 GERSPPRILPPCTNASTGAA 426
            |..|         ||.:|||
  Fly   457 GAGS---------NAGSGAA 467

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Runx1	NP_001104491.1	Runt	72..193	CDD:307137	97/121 (80%)
		RunxI	375..465	CDD:312115	18/57 (32%)
RunxA	NP_001259747.1	Runt	95..216	CDD:279225	97/120 (81%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	212	1.000	Domainoid score	I2765
eggNOG	1	0.900	-	-		E1_KOG3982
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000993
OrthoInspector	1	1.000	-	-		mtm8706
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11950
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X738
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.870