Protein Alignment Runx1 and RunxA

DIOPT Version :10

• Sequence 1: NP_001104491.1
• Gene: Runx1 / 12394
• MGIID: 99852
• Length: 465
• Species: Mus musculus
• Sequence 2: NP_001259747.1
• Gene: RunxA / 4379817
• FlyBaseID: FBgn0083981
• Length: 663
• Species: Drosophila melanogaster
• Alignment Length: 475
• Identity: 175/475 - (36%)
• Similarity: 220/475 - (46%)
• Gaps: 134/475 - (28%)

Mouse    22 STSRRFTPPSTALSPGKMSEALPLGAPDGGAALASKLRS---GDRSMVEVLADHPGELVRTDSPN 83
            |.:.:.|||:.|   ..::||.            :|:.|   .:|::.:.|.:|||||:||.||.
  Fly    57 SNTEQNTPPTPA---QLLNEAY------------TKMTSDILAERTLGDFLTEHPGELIRTSSPL 106

Mouse    84 FLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDL 148
            |:|:|||.|||.|||||:|||||:|||:.|||:|||.|||||||.|||||.||.||||||:||||
  Fly   107 FVCTVLPPHWRSNKTLPVAFKVVSLGDIMDGTMVTVRAGNDENYCAELRNCTAVMKNQVAKFNDL 171

Mouse   149 RFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPR-RHRQKLDDQTKPGSLSFSERL 212
            ||||||||||||||||||.||||.:|||::|||:||||||||| :....|..|.:....:|.:|
  Fly   172 RFVGRSGRGKSFTLTITVSTNPPHIATYNKAIKVTVDGPREPRSKTMLSLLGQQQQFHFAFGQR- 235

Mouse   213 SELEQLRRTAMRVSPHHPAPTPNPRASLNHSTAFNPQPQSQMQDARQIQPSPPWSYDQSYQ---- 273
                          |.|.:..|        .:.|...|....|.|....    |.|..:..
  Fly   236 --------------PFHFSTDP--------LSGFRMPPIGNCQSASNTH----WGYGSAASAYSP 274

Mouse   274 YLGSITSSSVHPATPISP---GRASGMTSLSAELSSRL----------------STAPDLTAFGD 319
            ||.|...||.  .||.|.   ..|.|.|..|.:.|:..                |||.||    |
  Fly   275 YLASSGLSSC--TTPTSAQFNNPALGFTCSSNDQSNNQDFGGATNRDCVPMLPDSTASDL----D 333

Mouse   320 PRQFPTLPSISDPRMHY-----------------------PGAFTYSPPVTSGIGIGMSAMSSA- 360
            ......:.|.|....|:                       .||.|......||.|.|..|..::
  Fly   334 QHLSSLVGSTSGQMTHHSLLGAGGQTSISSTVNGASGGGSAGAGTAGGGAGSGGGAGGGAGGNSI 398

Mouse   361 --SRYHTYL------------PPPYPGSSQAQAGPFQ-----TGSPSYHLYYGASAGSYQFSMVG 406
              .||||..            |.....||||:: |.|     |.:|:    .|::||....:  |
  Fly   399 LVPRYHTNASNEYNVHSSQNGPRSLSDSSQAES-PVQEDLLTTNTPN----LGSTAGGGAAN--G 456

Mouse   407 GERSPPRILPPCTNASTGAA 426
            |..|         ||.:|||
  Fly   457 GAGS---------NAGSGAA 467

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Runx1	NP_001104491.1	Runt	65..193	CDD:459963	98/128 (77%)
		RunxI	375..465	CDD:430037	18/57 (32%)
RunxA	NP_001259747.1	Runt	88..216	CDD:459963	98/127 (77%)