DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Runx1 and run

DIOPT Version :9

Sequence 1:	NP_001104491.1	Gene:	Runx1 / 12394	MGIID:	99852	Length:	465	Species:	Mus musculus
Sequence 2:	NP_001285501.1	Gene:	run / 33059	FlyBaseID:	FBgn0003300	Length:	510	Species:	Drosophila melanogaster

Alignment Length:	535	Identity:	162/535 - (30%)
Similarity:	222/535 - (41%)	Gaps:	179/535 - (33%)

- Green bases have known domain annotations that are detailed below.

Mouse    21 ASTSRRFTPPSTALSPGKMSEALPLGAPDGGAALASKLRSGDRSMVEVLADHPGELVRTDSPNFL 85
            ||::...||..:..:....|.|..  :|...|.:.|.:.....|:.|:|.::.|||.:|.||:.|
  Fly    65 ASSTGSSTPDLSTNNTSSSSNATT--SPQNSAKMPSSMTDMFASLHEMLQEYHGELAQTGSPSIL 127

Mouse    86 CSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRF 150
            ||.||.|||.||:||.||||:||.||||||||::..||||||..||||.|..||||||:||||||
  Fly   128 CSALPNHWRSNKSLPGAFKVIALDDVPDGTLVSIKCGNDENYCGELRNCTTTMKNQVAKFNDLRF 192

Mouse   151 VGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRRHRQKLDDQTKPGSLS-FSERLSE 214
            |||||||||||||||:.|.|.|:|:|.:|||:|||||||||..:..  ....||:.: |....:.
  Fly   193 VGRSGRGKSFTLTITIATYPVQIASYSKAIKVTVDGPREPRSKQSY--GYPHPGAFNPFMLNPAW 255

Mouse   215 LEQLRRT------------AMRVSPHHPA----------PTPNPRASLNHSTAFNPQPQSQMQDA 257
            |:....|            |.....||||          |.|||..:.:.|:|
  Fly   256 LDAAYMTYGYADYFRHQAAAQAAQVHHPALAKSSASSVSPNPNPSVATSSSSA------------ 308

Mouse   258 RQIQPSPPWSYDQSYQYLGSITSSSVHPATPISPGRASGMTSLSAELSSRLSTAPDLTAFGDPRQ 322
              :|||         :|        .|||..::                        .|.|.|..
  Fly   309 --VQPS---------EY--------PHPAAAVA------------------------AAAGQPAA 330

Mouse   323 FPTLPSISDPRMHYPGAFTYSPPVTSGIGIGMSAMSSASRYHTYLPPPYPGSSQAQAGPFQTGSP 387
            ....|         |||...:|                     |..|.:|.:..|.|...:..:|
  Fly   331 MMPSP---------PGAAPATP---------------------YAIPQFPFNHVAAAAAAKAATP 365

Mouse   388 -SYHLY-YGASAGSYQFSMVGGERSPPRILPPCTNASTGAA--------LLNPSLPSQS------ 436
             ::|.| :.|:||....:.....:|.|..:.|.::..:.::        .||.|:.:.|
  Fly   366 HAFHPYNFAAAAGLRARNAALHHQSEPVHVSPASSRPSSSSPTQQHVLLKLNTSIETSSIHEQSA 430

Mouse   437 ----------DVVETE---------------------------------GSHSNSPTNMP----- 453
                      |||::|                                 |:.:||....|
  Fly   431 SDGDSDDEQIDVVKSEFDLDKSLDVAPLRMRCDLKAPSAMKPLYHESGPGAVANSRQPSPETTTK 495

Mouse   454 ---PARLEEAVWRPY 465
               .|..::.|||||
  Fly   496 IKSAAVQQKTVWRPY 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Runx1	NP_001104491.1	Runt	72..193	CDD:307137	87/120 (73%)
Runx1	NP_001104491.1	RunxI	375..465	CDD:312115	27/156 (17%)
run	NP_001285501.1	Runt	114..235	CDD:279225	87/120 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3982
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	202	1.000	Inparanoid score	I3748
Isobase	1	0.950	-	0	Normalized mean entropy	S5099
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000993
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11950
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3284
SonicParanoid	1	1.000	-	-		X738
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.990