Protein Alignment Runx2 and lz

DIOPT Version :9

• Sequence 1: NP_001139510.1
• Gene: Runx2 / 12393
• MGIID: 99829
• Length: 528
• Species: Mus musculus
• Sequence 2: NP_511099.2
• Gene: lz / 31883
• FlyBaseID: FBgn0002576
• Length: 826
• Species: Drosophila melanogaster
• Alignment Length: 472
• Identity: 148/472 - (31%)
• Similarity: 202/472 - (42%)
• Gaps: 156/472 - (33%)

Mouse   115 DHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGEVPDGTVVTVMAGNDENYSAELRNAS 179
            :||.|||||.:|.||||.||:|||.|||||:|||||||.||.|||.||:.||||||..|||||.:
  Fly   282 EHPGELVRTSNPYFLCSALPAHWRSNKTLPMAFKVVALAEVGDGTYVTIRAGNDENCCAELRNFT 346

Mouse   180 AVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKVTVDGPREPRRHRQKLDDS 244
            ..|||.||:||||||||||||||||||||||.|:|||||||.:|||||||||||||
  Fly   347 TQMKNDVAKFNDLRFVGRSGRGKSFTLTITVATSPPQVATYAKAIKVTVDGPREPR--------- 402

Mouse   245 KPSLFSDRLSDLGRIPHPSMRVGVPPQNPRPSLNSAPSPFNPQGQSQITDPRQAQSSPPWSYDQS 309
                  .:.|..|...:.::.:|     .||.::..||   .:...::...|::
  Fly   403 ------SKTSPTGGPHYRALGLG-----QRPYIDGFPS---TKALHELESLRRS----------- 442

Mouse   310 YPSYLSQMTSPSIHSTTPLSSTR---------------------------GTGLPAITDVPRRIS 347
              :.::.:|:.:..:.|..|:..                           |.|...:..:....|
  Fly   443 --AKVAAVTTAAAAAATAASAANAVAAAAAAVAVTPTGGGGGVAAGGVAGGAGAGLVQQLSSNYS 505

Mouse   348 D-DDTATSDFCLW-PSS--LSKKSQAGASELGPFSDPRQFPSISSLTESRFSNPRMHYPAT---- 404
            . :.|..||..:: |::  :......||.|         :.:.||.:.:.:.:...|:|..
  Fly   506 SPNSTINSDCQVYKPNAPHIQAAEMMGAGE---------WTNGSSSSAAAYYHSHAHHPHAHHAH 561

Mouse   405 ------FTYTPP-----------------VTSGMSLGM--------------SATT--------- 423
                  ....||                 .|.||.:|:              ||.:
  Fly   562 AHLQHQMALPPPPPPPAAAPVSVGVGGNGATMGMGMGVGVGMGMNHYGGGYDSANSLEAGQYAAH 626

Mouse   424 --------HYHTYLPPPYP----------GSSQSQS-----GPF-QTSSTPY--LYYGTSSASYQ 462
                    |.|.:...||.          |.|.|:|     |.: |..|..|  ..||:..|:.|
  Fly   627 LPAVLPEMHGHGFATDPYQTAGYGGGNTGGGSASKSELDYGGSYNQAWSNGYQNYQYGSCLATAQ 691

Mouse   463 FPMVPGGDRSPSRMVPP 479
            :    |...:|....||
  Fly   692 Y----GPQAAPPPQPPP 704

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Runx2	NP_001139510.1	Runt	116..237	CDD:279225	95/120 (79%)
		RunxI	437..528	CDD:285676	15/51 (29%)
lz	NP_511099.2	Runt	283..404	CDD:279225	95/135 (70%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3982
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5786
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000993
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11950
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X738
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.820