DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ctnna1 and Vinc

DIOPT Version :9

Sequence 1:	NP_033948.1	Gene:	Ctnna1 / 12385	MGIID:	88274	Length:	906	Species:	Mus musculus
Sequence 2:	NP_001284813.1	Gene:	Vinc / 31201	FlyBaseID:	FBgn0004397	Length:	961	Species:	Drosophila melanogaster

Alignment Length:	1002	Identity:	226/1002 - (22%)
Similarity:	400/1002 - (39%)	Gaps:	209/1002 - (20%)

- Green bases have known domain annotations that are detailed below.

Mouse    22 TLAVERLLEPLVTQVTTLVNTNSKG-PSNKKRGRSKKAHVLAASVEQATENFLEKG-DKI-AKES 83
            |..:|.:|:|:..||:.||..:.:. ..|.....|:...|::|:|    .|.::.| |.| :.:.
  Fly     6 TKTIESILDPVAQQVSRLVILHEEAEDGNAMPDLSRPVQVVSAAV----ANLVKVGRDTINSSDD 66

Mouse    84 QFLKEELVVAVEDVRKQGDLMKSAAGEFADDPCSSVKRGNMVRAARALLSAVTRLLILADMADVY 148
            :.|::::..|:..|.....|::.|:.....||.|...|..::..:|.:|...:.||:..|.::|.
  Fly    67 KILRQDMPSALHRVEGASQLLEEASDMLRSDPYSGPARKKLIEGSRGILQGTSSLLLCFDESEVR 131

Mouse   149 KLLVQLKVVEDGILKLRNAGNEQDLGIQY-KALKPEVDKLNIMAAKRQQEL-------------- 198
            |::.:.|.|.| .|.:....|..:..:|: |.|.|.:.|::.....|::||
  Fly   132 KIIQECKRVLD-YLAVAEVINTMEQLVQFLKDLSPCLSKVHREVGAREKELTHQVHSEILVRCLE 195

Mouse   199 ----------------------------KDVGNRDQMAAARG-ILQKNVPILY--TASQACLQHP 232
                                        :...||:.:||... .||:.:.:|.  |..:...:..
  Fly   196 QVKTLAPILICSMKVYIHIVEQQGRGAEEAAENRNYLAARMSDELQEIIRVLQLTTYDEDTSELD 260

Mouse   233 DVAAYKANRDLIYKQLQQAVTGISN--AAQATASDDAAQHQGGSGGEL--------AYALNNFDK 287
            ::...|...:.|..:::||...:||  |.:....:.|.:....:..|:        :|.:.....
  Fly   261 NLTVLKKLSNAISNKMEQANEWLSNPYALRGGVGEKALRQVIDNATEISERCLPQDSYPIRKLAD 325

Mouse   288 QIIVDPLSFSEERFR-----PSLEE----------RLESIISGAALMAD------SSCTRDDRRE 331
            ::.....:..|.|..     |..|.          .|:|::..|.|..|      ::.|...|.|
  Fly   326 EVTAMANTLCELRQEGKGQSPQAESLVRGIRDRMGELKSLVHQAVLGVDKAGVQQTAHTIQGRLE 390

Mouse   332 ----------------------------RIVAE-CNAVRQA-LQDLLSEYMGNAGRKER-----S 361
                                        |.||| |...::| :|.|..|    ..|.:|     .
  Fly   391 QAVKWLQHPEINDGGLGERAINLIVEEGRKVAEGCPGHQKAEIQQLCDE----VERLKRQAAGSG 451

Mouse   362 DALNSAIDKMTKKTRDLRRQLRKAVMDHVSDSFLETNVPLLVLIEAA----------KNGNEKEV 416
            .|...|..::|:|..:|:..::.|:::.:...|::.:.||....||.          :|.|:|
  Fly   452 PAAKQAAKQLTQKLYELKAAIQNALVNRIVQDFMDVSTPLKQFTEAVLQPEGTPGREQNFNQK-- 514

Mouse   417 KEYAQVFREHANKL--IEVANLACSISNNEEGVKLVRMSASQLEALCPQVINAALALAAKPQSKL 479
            ....|.|.:.|:|.  :..|..||   .|::..:::..||:|:::|.||:|:|.......|.||.
  Fly   515 SNNLQAFSDRASKTSRMVAAGGAC---GNKKIAEILLSSAAQVDSLTPQLISAGRIRMNYPGSKA 576

Mouse   480 AQENMDLFKEQWEKQVRVLTDAVDDITSIDDFLAVSENHILEDVNKCVIALQ----EKDVDGLDR 540
            |.|::...|:|:...|..:....|..|...||:..||.|:......|..|:.    :|.||....
  Fly   577 ADEHLQNLKQQYADTVLRMRTLCDQATDPADFIKTSEEHMQVYAKLCEDAIHARQPQKMVDNTSN 641

Mouse   541 TAGAIRGRAARVIHVVTSEMDNYEPGVYTEKVLEATKLLSNTVMPRFTEQVEAAVEALSSDPAQP 605
            .|..|.    ||:.|...|.||.|..|:||::..|...|..: :|......:.....::...|..
  Fly   642 IARLIN----RVLLVAKQEADNSEDPVFTERLNAAANRLERS-LPAMVGDAKLVATNIADPAAAA 701

Mouse   606 MDENEFIDASRLVYDGIRDIRKAVLMIRTPEELDDSDFETEDFDVRSRTSVQTEDDQL----IAG 666
            ..:|.|   .||:.| :|::|.|:...:.|.               ..||:.....:|    ::.
  Fly   702 AWKNSF---QRLLGD-VREVRDAIAPPQPPP---------------LPTSLPPPIPELSALHLSN 747

Mouse   667 QSARAIMAQ--LPQEQKAKIAEQVASFQEEKS------------------KLDAEVSKWDDSGND 711
            |:|.....:  ||:|..|.:........:|..                  .|..||.:|....|:
  Fly   748 QNAERAPPRPPLPREGLAPVRPPPPETDDEDEGVFRTMPHANQPILIAARGLHQEVRQWSSKDNE 812

Mouse   712 IIVLAKQMCMIMMEMTDF----TRGKGPLKNTSDVISAAKKIAEAGSRMDKLGRTIADHCPDSAC 772
            ||..||:|.::|..:::.    :||     :..::|:.|||||||...:.:|.:.:|..|.|...
  Fly   813 IIAAAKRMAILMARLSELVLSDSRG-----SKRELIATAKKIAEASEDVTRLAKELARQCTDRRI 872

Mouse   773 KQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELVVSGVDSAMSLIQAAKNLMNAVVQTVKASY 837
            :.:||...:||.....||.|.|.|||.:  ||.:......::...|:..|:|||.:|.:||:|:.
  Fly   873 RTNLLQVCERIPTIGTQLKILSTVKATM--LGAQGSDEDREATEMLVGNAQNLMQSVKETVRAAE 935

Mouse   838 VASTKYQKSQGMASLNLPAVSWKMKAP 864
            .||.|.:..|....|     .|..:.|
  Fly   936 GASIKIRSDQTSNRL-----QWVRRQP 957

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ctnna1	NP_033948.1	Involved in homodimerization. /evidence=ECO:0000250	2..228		54/254 (21%)
		Vinculin	19..867	CDD:366435	226/1002 (23%)
		Interaction with JUP and CTNNB1. /evidence=ECO:0000250	97..148		12/50 (24%)
		Interaction with alpha-actinin. /evidence=ECO:0000250	325..394		20/103 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	864..894		1/1 (100%)
Vinc	NP_001284813.1	Vinculin	63..960	CDD:279395	209/941 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3681
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810