DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Casp9 and Strica

DIOPT Version :9

Sequence 1:	NP_056548.2	Gene:	Casp9 / 12371	MGIID:	1277950	Length:	454	Species:	Mus musculus
Sequence 2:	NP_001260718.1	Gene:	Strica / 35528	FlyBaseID:	FBgn0033051	Length:	527	Species:	Drosophila melanogaster

Alignment Length:	317	Identity:	84/317 - (26%)
Similarity:	127/317 - (40%)	Gaps:	61/317 - (19%)

- Green bases have known domain annotations that are detailed below.

Mouse   151 PARLKPEVLRPETPRP-VDIGSGG---------AHDVCVPGKIR---GHADMAYTLDSDPCGHCL 202
            |.::...:....||:| :.:||.|         |......|.|.   |.:..:.|.:........
  Fly   252 PKQVDKPLSSTATPKPFISLGSSGGTKPKVTAVAQSQDAQGTISTSLGISKSSLTKNKLKPARVY 316

Mouse   203 IINNVNFCPSSGLGTRTGSNLDRDKLEHRFRWLRFMVEVKND---LTAKKMVTALMEMAHRNHRA 264
            |.|:..|...:..  |.||..|...|...|..|:..|||..|   :|.||.|..|......:..|
  Fly   317 IFNHERFDNKNEF--RKGSAQDVKVLRATFEQLKCKVEVITDATLVTIKKTVRMLQTKDFEDKSA 379

Mouse   265 LDCFVVVILSHGCQASHLQFPGAVYGTDGCSVSIEKIVNIFNGSGCPSLGGKPKLFFIQACGGEQ 329
            |   |:||||||.:  |.|....   .|..|:..:.:..|....   :|..||||.|:|||.|:.
  Fly   380 L---VLVILSHGTR--HDQIAAK---DDDYSLDDDVVFPILRNR---TLKDKPKLIFVQACKGDC 433

Mouse   330 KDHGFEVACTSSQGRTLDSDSEPDAVPYQEGPRPLDQLDAVSSLPTPSDILVSYSTFPGFVSWRD 394
            :..||                               ..||.....:|::||..|||:.||||:|
  Fly   434 QLGGF-------------------------------MTDAAQPNGSPNEILKCYSTYEGFVSFR- 466

Mouse   395 KKSGSWYIETLDGILEQWARSEDLQSLLLRVANAVSAKGTYKQIPGCFNFLRKKLFF 451
            .:.|:.:|:||...|.:..::.|:.::::.|...|..:...:|||...:.|..|..|
  Fly   467 TEDGTPFIQTLCEALNRSGKTSDIDTIMMNVRQVVKMQSKDRQIPSVTSTLTSKYVF 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Casp9	NP_056548.2	CARD_CASP9	5..90	CDD:176740
Casp9	NP_056548.2	CASc	190..452	CDD:237997	73/265 (28%)
Strica	NP_001260718.1	CASc	311..523	CDD:294037	71/256 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3573
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6822
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.760