DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Casp2 and Drice

DIOPT Version :9

Sequence 1:	NP_031636.1	Gene:	Casp2 / 12366	MGIID:	97295	Length:	452	Species:	Mus musculus
Sequence 2:	NP_524551.2	Gene:	Drice / 43514	FlyBaseID:	FBgn0019972	Length:	339	Species:	Drosophila melanogaster

Alignment Length:	276	Identity:	81/276 - (29%)
Similarity:	137/276 - (49%)	Gaps:	17/276 - (6%)

- Green bases have known domain annotations that are detailed below.

Mouse   165 LDNGDGPPCLLVKPCTPEFYQAHYQLAYRLQSQPRGLALVLSNVHFTGEKDLEFRSGGDVDHTTL 229
            |.||...|....:....:.....:...|.::.:.||:||:.::.||. ...|:.|:|.:||...|
  Fly    59 LANGYSSPSSSYRKNVAKMVTDRHAAEYNMRHKNRGMALIFNHEHFE-VPTLKSRAGTNVDCENL 122

Mouse   230 VTLFKLLGYNVHVLHDQTAQEMQEKLQNFAQLPAHRVTDSCVVALLSHGVEGGIYGVDGKLLQLQ 294
            ..:.|.|.:.|.|..|...:::...:: :|....|..:|..:||:||||..|.||..|.: .:|.
  Fly   123 TRVLKQLDFEVTVYKDCRYKDILRTIE-YAASQNHSDSDCILVAILSHGEMGYIYAKDTQ-YKLD 185

Mouse   295 EVFRLFDNANCPSLQNKPKMFFIQACRGDETDRGVDQQDGKNHTQSPGCEESDAGKEELMKMRLP 359
            .::..|...:||||..|||:||||||:||..|.||..|  ::.|::.|        :..|..::|
  Fly   186 NIWSFFTANHCPSLAGKPKLFFIQACQGDRLDGGVTMQ--RSQTETDG--------DSSMSYKIP 240

Mouse   360 TRSDMICGYACLKGNAAMRNTKRGSWYIEALTQVFSERACDMHVADMLVKV-NALIKEREGYAPG 423
            ..:|.:..|:.:.|..:.|||.||||::::|....:.....:.:..:|..| ..:..:.|...|.
  Fly   241 VHADFLIAYSTVPGFYSWRNTTRGSWFMQSLCAELAANGKRLDILTLLTFVCQRVAVDFESCTPD 305

Mouse   424 T-EFHRCKEMSEYCST 438
            | |.|:.|::.  |.|
  Fly   306 TPEMHQQKQIP--CIT 319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Casp2	NP_031636.1	CARD_CASP2	32..118	CDD:260040
		CASc	192..447	CDD:214521	77/249 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	327..349		5/21 (24%)
Drice	NP_524551.2	CASc	86..330	CDD:214521	77/249 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3573
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10454
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910