DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Casp2 and Decay

DIOPT Version :9

Sequence 1:	NP_031636.1	Gene:	Casp2 / 12366	MGIID:	97295	Length:	452	Species:	Mus musculus
Sequence 2:	NP_477462.1	Gene:	Decay / 42008	FlyBaseID:	FBgn0028381	Length:	308	Species:	Drosophila melanogaster

Alignment Length:	254	Identity:	69/254 - (27%)
Similarity:	122/254 - (48%)	Gaps:	15/254 - (5%)

- Green bases have known domain annotations that are detailed below.

Mouse   200 GLALVLSNVHFTGEKDLEFRSGGDVDHTTLVTLFKLLGYNVHVLHDQTAQEMQEKLQNFAQLPAH 264
            |:||:|::....|:|.   |.|.:.|...:....:..|::|....|.|..|:.:.|:..|: ..|
  Fly    56 GIALILNHKDVKGQKQ---RVGTERDRDDMEATLQGFGFDVRTFDDLTFSEINDTLKEVAR-EDH 116

Mouse   265 RVTDSCVVALLSHGVEGGIYGVDGKLLQLQEVFRLFDNANCPSLQNKPKMFFIQACRGDETDRGV 329
            ...|..|:|::|||.||.:|..| ....::.::..|...||.:|:||||:||||||||...::.|
  Fly   117 SQNDCFVLAVMSHGTEGKVYAKD-MSYPVERLWNPFLGDNCKTLKNKPKLFFIQACRGANLEKAV 180

Mouse   330 DQQDGKNHTQSPGCEESDAGKEELMKMRLPTRSDMICGYACLKGNAAMRNTKRGSWYIEALTQVF 394
            :.......|:.  .....|...:.:...:|:.:|::..|:......:.||...|||:|::|.:|.
  Fly   181 EFSSFAVMTRE--LVPEPAAAVQPITYAIPSTADILVFYSTFDKFFSFRNVDDGSWFIQSLCRVL 243

Mouse   395 SERACD-------MHVADMLVKVNALIK-EREGYAPGTEFHRCKEMSEYCSTLCQQLYL 445
            .:.|.:       :.:..:|..||..:. |.:........::.|||..:.|||.:...|
  Fly   244 DQAAANEAATPEGVELLRLLTAVNRKVAYEYQSNTKNEALNQMKEMPNFMSTLTKTFQL 302

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Casp2	NP_031636.1	CARD_CASP2	32..118	CDD:260040
		CASc	192..447	CDD:214521	69/254 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	327..349		2/21 (10%)
Decay	NP_477462.1	CASc	54..302	CDD:237997	68/252 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842780
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3573
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740