DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Casp12 and Decay

DIOPT Version :9

Sequence 1:	XP_036010474.1	Gene:	Casp12 / 12364	MGIID:	1312922	Length:	425	Species:	Mus musculus
Sequence 2:	NP_477462.1	Gene:	Decay / 42008	FlyBaseID:	FBgn0028381	Length:	308	Species:	Drosophila melanogaster

Alignment Length:	353	Identity:	78/353 - (22%)
Similarity:	133/353 - (37%)	Gaps:	96/353 - (27%)

- Green bases have known domain annotations that are detailed below.

Mouse    97 DEDDGPQKICTPSSPSESKRKVEDDEMEVNAGLAHESHLMLTAPHGLQSSEVQDTLKLCPRDQFC 161
            |:.|..:...||:|..:.||                  ::::.|..      :||.:.|
  Fly    18 DKADATKIAHTPTSELDLKR------------------IIISRPTN------EDTYENC------ 52

Mouse   162 KIKTERAKEIYPVMEKEGRTRLALIICNKKFDYLFDRDNADTDILNMQELLENLGYSVVLKENLT 226
                             .|..:|||:.:|.......|...:.|..:|:..|:..|:.|...::||
  Fly    53 -----------------ARAGIALILNHKDVKGQKQRVGTERDRDDMEATLQGFGFDVRTFDDLT 100

Mouse   227 AQEMETELMQFAGRPEHQSSDSTFLVFMSHGILEGICGVKHRNKKPDVLHD-DTIFKIFNNSNCR 290
            ..|:...|.:.| |.:|..:|...|..|||| .||....|      |:.:. :.::..|...||:
  Fly   101 FSEINDTLKEVA-REDHSQNDCFVLAVMSHG-TEGKVYAK------DMSYPVERLWNPFLGDNCK 157

Mouse   291 SLRNKPKILIMQACRGRYNGTIWVSTNKGIATADTDEERVLSCKWNNSITKAHVET-DFIAFKSS 354
            :|:||||:..:|||||.........::..:.|.:...|...:.:   .||.|...| |.:.|.|:
  Fly   158 TLKNKPKLFFIQACRGANLEKAVEFSSFAVMTRELVPEPAAAVQ---PITYAIPSTADILVFYST 219

Mouse   355 TPHNISWKVGKTGSLFISKLIDCFKKYCWCYHLEE--------------------IFRKVQHSF- 398
            .....|::....||.||..|         |..|::                    :.|||.:.:
  Fly   220 FDKFFSFRNVDDGSWFIQSL---------CRVLDQAAANEAATPEGVELLRLLTAVNRKVAYEYQ 275

Mouse   399 -----EVPGELTQMPTIERVSMTRYFYL 421
                 |...::.:||.. ..::|:.|.|
  Fly   276 SNTKNEALNQMKEMPNF-MSTLTKTFQL 302

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Casp12	XP_036010474.1	CARD_CASP1-like	12..94	CDD:260036
Casp12	XP_036010474.1	CASc	172..423	CDD:214521	67/278 (24%)
Decay	NP_477462.1	CASc	54..302	CDD:237997	66/268 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842790
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3573
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740