DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Casp12 and Dcp-1

DIOPT Version :9

Sequence 1:	XP_036010474.1	Gene:	Casp12 / 12364	MGIID:	1312922	Length:	425	Species:	Mus musculus
Sequence 2:	NP_476974.1	Gene:	Dcp-1 / 37729	FlyBaseID:	FBgn0010501	Length:	323	Species:	Drosophila melanogaster

Alignment Length:	270	Identity:	71/270 - (26%)
Similarity:	121/270 - (44%)	Gaps:	40/270 - (14%)

- Green bases have known domain annotations that are detailed below.

Mouse   156 PRDQF-CKIKTERAKEIYPVMEKEGRTRLALIICNKKFDY--LFDRDNADTDILNMQELLENLGY 217
            |.::| .::..||....|.:..|  ...:|||..::.||.  |..|...:.|...:::..||||:
  Fly    54 PANKFVARMPVERYASEYNMSHK--HRGVALIFNHEFFDIPSLKSRTGTNVDAQELKKAFENLGF 116

Mouse   218 SVVLKENLTAQEMETELMQFAGRP---EHQSSDSTFLVFMSHGILEGICGVKHRNKKPDVLHDDT 279
            :|.:.::...:    ::::..|:.   :|..:|...:..:||| ..|....|....|.     |.
  Fly   117 AVSVHKDCKLR----DILKHVGKAAELDHTDNDCLAVAILSHG-EHGYLYAKDTQYKL-----DN 171

Mouse   280 IFKIFNNSNCRSLRNKPKILIMQACRG-RYNGTIWVSTNKGIATADTDEERVLSCKWNNSITKAH 343
            |:..|..:.|.||..|||:..:|||:| |.:|.|  :..||:  .:||.|       :::..|..
  Fly   172 IWHYFTATFCPSLAGKPKLFFIQACQGDRLDGGI--TLEKGV--TETDGE-------SSTSYKIP 225

Mouse   344 VETDFIAFKSSTPHNISWKVGKTGSLFISKLIDCF----KKYCWCYHLEEIFRKVQHSFE--VPG 402
            :..||:...|:.|...||:....||.::..||...    |||.....|..:.::|...||  ||.
  Fly   226 IHADFLFSYSTIPGYFSWRNINNGSWYMQSLIRELNANGKKYDLLTLLTFVNQRVALDFESNVPA 290

Mouse   403 ELTQMPTIER 412
                .|.::|
  Fly   291 ----TPMMDR 296

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Casp12	XP_036010474.1	CARD_CASP1-like	12..94	CDD:260036
Casp12	XP_036010474.1	CASc	172..423	CDD:214521	67/253 (26%)
Dcp-1	NP_476974.1	CASc	71..313	CDD:214521	67/253 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3573
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10454
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910