DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Casp4 and Strica

DIOPT Version :9

Sequence 1:	NP_031635.2	Gene:	Casp4 / 12363	MGIID:	107700	Length:	373	Species:	Mus musculus
Sequence 2:	NP_001260718.1	Gene:	Strica / 35528	FlyBaseID:	FBgn0033051	Length:	527	Species:	Drosophila melanogaster

Alignment Length:	308	Identity:	66/308 - (21%)
Similarity:	117/308 - (37%)	Gaps:	68/308 - (22%)

- Green bases have known domain annotations that are detailed below.

Mouse    91 EMEEPEESLNTLKLCSPEEFTRL-----CREKTQEIYPIKEANGRTRKALIICNTE--------- 141
            ::::|..|..|     |:.|..|     .:.|...:...::|.|....:|.|..:.
  Fly   254 QVDKPLSSTAT-----PKPFISLGSSGGTKPKVTAVAQSQDAQGTISTSLGISKSSLTKNKLKPA 313

Mouse   142 ----FKH------LSLRYGANFDIIGMKGLLEDLGYDVVVKEELTAEGMES-----EMKDFAALS 191
                |.|      ...|.|:..|:..::...|.|...|.|..:.|...::.     :.|||
  Fly   314 RVYIFNHERFDNKNEFRKGSAQDVKVLRATFEQLKCKVEVITDATLVTIKKTVRMLQTKDF---- 374

Mouse   192 EHQTSDSTFLVLMSHGTLHGICGTMHSEKTPDVLQYDTIYQIFNNCHCPGLRDKPKVIIVQACRG 256
              :...:..||::||||.|........:.:   |..|.::.|..|   ..|:||||:|.||||:|
  Fly   375 --EDKSALVLVILSHGTRHDQIAAKDDDYS---LDDDVVFPILRN---RTLKDKPKLIFVQACKG 431

Mouse   257 GNSGEMWIRESSKPQLCR-GVDLPRNMEADAVKLSHVEKDFIAFYSTTPHHLSYRDKTGGSYFIT 320
            .               |: |     ....||.:.:....:.:..|||....:|:|.: .|:.||.
  Fly   432 D---------------CQLG-----GFMTDAAQPNGSPNEILKCYSTYEGFVSFRTE-DGTPFIQ 475

Mouse   321 RLISCFRKHACSCHLFDIFLKVQQSFEKASIHSQMPTIDRATLTRYFY 368
            .|.....:...:..:..|.:.|:|..:..|...|:|::.....::|.:
  Fly   476 TLCEALNRSGKTSDIDTIMMNVRQVVKMQSKDRQIPSVTSTLTSKYVF 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Casp4	NP_031635.2	Required for LPS-binding. /evidence=ECO:0000269\|PubMed:25119034	1..59
		CARD_CASP1-like	5..85	CDD:260036
		CASc	122..371	CDD:214521	59/272 (22%)
Strica	NP_001260718.1	CASc	311..523	CDD:294037	55/244 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3573
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810