DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Casp1 and Decay

DIOPT Version :9

Sequence 1:	NP_033937.2	Gene:	Casp1 / 12362	MGIID:	96544	Length:	402	Species:	Mus musculus
Sequence 2:	NP_477462.1	Gene:	Decay / 42008	FlyBaseID:	FBgn0028381	Length:	308	Species:	Drosophila melanogaster

Alignment Length:	318	Identity:	79/318 - (24%)
Similarity:	133/318 - (41%)	Gaps:	59/318 - (18%)

- Green bases have known domain annotations that are detailed below.

Mouse   113 ETKEEQNKEDGTFPGLTGTLKFCPLEKAQKLWKENPS--EIYPIMNTTTRTRLALIICNTEFQHL 175
            :.|.:::|.|.|....|.|.:.    ..:::....|:  :.|   ....|..:|||:.:.:.:..
  Fly    12 KNKHKKDKADATKIAHTPTSEL----DLKRIIISRPTNEDTY---ENCARAGIALILNHKDVKGQ 69

Mouse   176 SPRVGAQVDLREMKLLLEDLGYTVKVKENLTALEMVKEVKEFAACPEHKTSDSTFLVFMSHGIQE 240
            ..|||.:.|..:|:..|:..|:.|:..::||..|:...:||.|. .:|..:|...|..||||.:
  Fly    70 KQRVGTERDRDDMEATLQGFGFDVRTFDDLTFSEINDTLKEVAR-EDHSQNDCFVLAVMSHGTE- 132

Mouse   241 GICGTTYSNEVSDILKVDTIFQMMNTLKCPSLKDKPKVIIIQACRGEKQGVVLLKDSVRDSEEDF 305
               |..|:.::|  ..|:.::.......|.:||:|||:..||||||..     |:.:|..|....
  Fly   133 ---GKVYAKDMS--YPVERLWNPFLGDNCKTLKNKPKLFFIQACRGAN-----LEKAVEFSSFAV 187

Mouse   306 LTDAIFEDDGIKKAHI------EKDFIAFCSSTPDNVSWRHPVRGSLFIESLIKHMKEYAWSCD- 363
            :|..:..:.......|      ..|.:.|.|:.....|:|:...||.||:||.:.:.:.|.:..
  Fly   188 MTRELVPEPAAAVQPITYAIPSTADILVFYSTFDKFFSFRNVDDGSWFIQSLCRVLDQAAANEAA 252

Mouse   364 ----------LEDIFRKVRFSF-------------EQPEFRLQMPTADRVTLTKRFYL 398
                      |..:.|||.:.:             |.|.|        ..||||.|.|
  Fly   253 TPEGVELLRLLTAVNRKVAYEYQSNTKNEALNQMKEMPNF--------MSTLTKTFQL 302

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Casp1	NP_033937.2	CARD_CASP1-like	6..87	CDD:260036
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	98..125		3/11 (27%)
		CASc	152..400	CDD:214521	72/277 (26%)
Decay	NP_477462.1	CASc	54..302	CDD:237997	70/267 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842792
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3573
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740