Protein Alignment CCR5 and AstA-R1

DIOPT Version :10

• Sequence 1: NP_000570.1
• Gene: CCR5 / 1234
• HGNCID: 1606
• Length: 352
• Species: Homo sapiens
• Sequence 2: NP_524700.1
• Gene: AstA-R1 / 44126
• FlyBaseID: FBgn0266429
• Length: 394
• Species: Drosophila melanogaster
• Alignment Length: 323
• Identity: 81/323 - (25%)
• Similarity: 161/323 - (49%)
• Gaps: 38/323 - (11%)

Human    13 NY-YTSE---------------PCQKINVKQIAARLLPPLYSLVFIFGFVGNMLVILILINCKRL 61
            || :|||               ..:.:.:::|.:.::|..:.::...|.:||.||||:::..:::
  Fly    41 NYAFTSEHTDHSDHNANDSMEYDAESVALERIVSTIVPVFFGIIGFAGLLGNGLVILVVVANQQM 105

Human    62 KSMTDIYLLNLAISD-LFFLLTVPFWA-HYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFIILLTI 124
            :|.|::.::|||:|| ||.:..|||.| .|...:|.|||..|:.:..:..:.....::.::|::.
  Fly   106 RSTTNLLIINLAVSDILFVIFCVPFTATDYVLPEWPFGNVWCKFVQYMIVVTCHCSVYTLVLMSF 170

Human   125 DRYLAVVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQKEGLHYTCSSHFPYS-QYQ 188
            ||:|||||.|.::..||.....:..:..|:..|..::|..:....:....|....:...:| :.:
  Fly   171 DRFLAVVHPVTSMSLRTERNATLAIMCAWITIVTTAIPVALSHSVRIYQYHGNAGTACVFSTEEE 235

Human   189 FWK--NFQTLKIVILGLVLPLLVMVICYSGILKTLLR----CR----NEKKRHRAVRLIFTIMIV 243
            .|.  .|| :...:...|.||.::...|.|:|..|.:    |:    :.|.:.|..|::..:::.
  Fly   236 IWSLVGFQ-VSFFLSSYVAPLTLICFLYMGMLARLWKSAPGCKPSAESRKGKRRVTRMVVVVVLA 299

Human   244 YFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQ-VTETLGMTHCCINPIIYAFVGEKFR 305
            :.:.|.|.:::|:|...       |....:.|...:| ::..:..|:.|||||:|||:.:.||
  Fly   300 FAICWLPIHVILVLKAL-------NLYGGSHLSVIIQIISHVVAYTNSCINPILYAFLSDNFR 355

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCR5	NP_000570.1	7tmA_CCR5_CCR2	31..308	CDD:341338	75/289 (26%)
		TM helix 1	31..58	CDD:341338	8/26 (31%)
		TM helix 2	65..90	CDD:341338	12/26 (46%)
		TM helix 3	101..131	CDD:341338	6/29 (21%)
		TM helix 4	143..165	CDD:341338	3/21 (14%)
		TM helix 5	191..220	CDD:341338	8/30 (27%)
		TM helix 6	228..258	CDD:341338	6/29 (21%)
		TM helix 7	276..301	CDD:341338	10/25 (40%)
AstA-R1	NP_524700.1	7tmA_AstA_R_insect	75..358	CDD:320224	75/289 (26%)
		TM helix 1	76..102	CDD:320224	8/25 (32%)
		TM helix 2	109..135	CDD:320224	12/25 (48%)
		TM helix 3	147..177	CDD:320224	6/29 (21%)
		TM helix 4	189..209	CDD:320224	2/19 (11%)
		TM helix 5	239..268	CDD:320224	8/29 (28%)
		TM helix 6	284..314	CDD:320224	6/29 (21%)
		TM helix 7	326..351	CDD:320224	10/24 (42%)