Protein Alignment CCR5 and AstA-R2

DIOPT Version :10

• Sequence 1: NP_000570.1
• Gene: CCR5 / 1234
• HGNCID: 1606
• Length: 352
• Species: Homo sapiens
• Sequence 2: NP_524544.1
• Gene: AstA-R2 / 43393
• FlyBaseID: FBgn0039595
• Length: 357
• Species: Drosophila melanogaster
• Alignment Length: 363
• Identity: 102/363 - (28%)
• Similarity: 173/363 - (47%)
• Gaps: 60/363 - (16%)

Human    13 NYYTSEPCQKINVKQIAARLLPPL----YSLVFIFGFVGNMLVILILINCKRLKSMTDIYLLNLA 73
            :::|.|....||      ..||.:    :.::.|.||.||:||||:::....::|.|::.::|||
  Fly    23 SFFTDEEWLAIN------GTLPWIVGFFFGVIAITGFFGNLLVILVVVFNNNMRSTTNLMIVNLA 81

Human    74 ISDLFF-LLTVPFWA-HYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAVVHAVFA 136
            .:||.| :|.:||.| .|....|.:|...|:.:..|..:..|:.|:.::|::|||:|||||.:.:
  Fly    82 AADLMFVILCIPFTATDYMVYYWPYGRFWCRSVQYLIVVTAFASIYTLVLMSIDRFLAVVHPIRS 146

Human   137 LKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQKEGLHYTCSSHFPYSQYQFWKN-------FQ 194
            ...||....::..|..|:|.:..|:| :.||....  :.|....:..|....|..|       :|
  Fly   147 RMMRTENITLIAIVTLWIVVLVVSVP-VAFTHDVV--VDYDAKKNITYGMCTFTTNDFLGPRTYQ 208

Human   195 TLKIVILGLVLPLLVMVICYSGILKTLLR--------CRNEKKRHRAVRLIFTIMIVYFLFWAPY 251
             :...|...:|||:::...|..::..|.|        ..:::.|.|..||:..::|.:...|.|.
  Fly   209 -VTFFISSYLLPLMIISGLYMRMIMRLWRQGTGVRMSKESQRGRKRVTRLVVVVVIAFASLWLPV 272

Human   252 NIVLLLNTFQEFFGLNNCSSSNRLDQ-AMQVT-ETLGMTHCCINPIIYAFVGEKFRNYLLVFFQK 314
            .::|||.:.       :...:|.|.: .:||| :||..:..||||::|||:.|.||
  Fly   273 QLILLLKSL-------DVIETNTLTKLVIQVTAQTLAYSSSCINPLLYAFLSENFR--------- 321

Human   315 HIAKRFCK---CCSIFQQ-----EAPERASSVYTRSTG 344
               |.|.|   |.|.:|.     ..|.:.|...|.:||
  Fly   322 ---KAFYKAVNCSSRYQNYTSDLPPPRKTSCARTSTTG 356

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCR5	NP_000570.1	7tmA_CCR5_CCR2	31..308	CDD:341338	87/299 (29%)
		TM helix 1	31..58	CDD:341338	11/30 (37%)
		TM helix 2	65..90	CDD:341338	11/26 (42%)
		TM helix 3	101..131	CDD:341338	10/29 (34%)
		TM helix 4	143..165	CDD:341338	5/21 (24%)
		TM helix 5	191..220	CDD:341338	7/35 (20%)
		TM helix 6	228..258	CDD:341338	9/29 (31%)
		TM helix 7	276..301	CDD:341338	12/26 (46%)
AstA-R2	NP_524544.1	7tmA_AstA_R_insect	39..324	CDD:320224	86/307 (28%)
		TM helix 1	40..66	CDD:320224	9/25 (36%)
		TM helix 2	73..99	CDD:320224	11/25 (44%)
		TM helix 3	111..141	CDD:320224	10/29 (34%)
		TM helix 4	153..173	CDD:320224	5/20 (25%)
		TM helix 5	204..233	CDD:320224	6/29 (21%)
		TM helix 6	249..279	CDD:320224	9/29 (31%)
		TM helix 7	292..317	CDD:320224	12/24 (50%)