DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LRRC28 and cyr1

DIOPT Version :9

Sequence 1:	NP_001308604.1	Gene:	LRRC28 / 123355	HGNCID:	28355	Length:	367	Species:	Homo sapiens
Sequence 2:	NP_596159.1	Gene:	cyr1 / 2540810	PomBaseID:	SPBC19C7.03	Length:	1692	Species:	Schizosaccharomyces pombe

Alignment Length:	362	Identity:	82/362 - (22%)
Similarity:	133/362 - (36%)	Gaps:	97/362 - (26%)

- Green bases have known domain annotations that are detailed below.

Human     4 ELCKTISVARLEKHKNL---------------FLNYRNLHHFPLELLKDEGL--QYLERLYMKRN 51
            |.|  :.:.||:...||               .||......:.|:.|...||  ..|:.|.:..|
pombe   450 ERC--VKLKRLDISNNLRSPRGKPITALRQLEVLNMSRNDIYELDPLIFSGLSRNSLKELNIANN 512

Human    52 SLTSLPENLAQKLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHL 116
            .|..||.: .:.|.||..|.|..||.|..|..|..|.:|:.|:.|.|.|..:..:||.|..|:||
pombe   513 KLFFLPHS-TRYLVNLTYLDLSYNNFVTFPLIITELSQLETLNFSHNLLSQISSKIGSLVKLKHL 576

Human   117 RLANNQL-QFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLP 180
            .|..|.| ..||.|:|.||.|:|:|:|.|.:..:..                        |.:.|
pombe   577 YLQFNDLSNRLPQEIGLLKNLETIDLSYNAITNIAS------------------------LSECP 617

Human   181 SLNELSMAGNRLAFLPLDLGRSRELQYVY-----VDNNIHLKGLPSYLYNKVIGCSGCGAPIQVS 240
            .||.:::|.|.|:|.......:..:.:.:     :|        |::.|:.::       ...:|
pombe   618 KLNSINVACNLLSFYEYSNPSATFIDFSFCPLTTID--------PAFSYSNLV-------YFDIS 667

Human   241 EVKLLSFSSGQRTVFLPAEVKAIGTEHDHVLPLQELAMRGLYHTYHSLLKDLNFLSPISLPRSLL 305
            ..||:.....  .:.....|:.:...::|...:.:..         |.:::|.:||
pombe   668 HAKLIGLKDS--VIETLVNVETVKVNYNHFTSISDAI---------SAMQNLKYLS--------- 712

Human   306 ELLHCPLGHCHRCSEPMFTIVYPKLFPLRETPMAGLH 342
                     |..|.   .:.|.|.|..|:......||
pombe   713 ---------CTNCE---MSYVSPNLGKLKHLVHLDLH 737

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LRRC28	NP_001308604.1	LRR 1	16..36		5/34 (15%)
		LRR 2	42..63		6/20 (30%)
		leucine-rich repeat	43..66	CDD:275380	7/22 (32%)
		NEL	<46..>306	CDD:330839	61/265 (23%)
		LRR 3	66..87		9/20 (45%)
		leucine-rich repeat	67..89	CDD:275380	9/21 (43%)
		LRR 4	89..110		7/20 (35%)
		leucine-rich repeat	90..135	CDD:275380	19/45 (42%)
		LRR 5	112..133		10/21 (48%)
		LRR 6	135..156		5/20 (25%)
		leucine-rich repeat	136..158	CDD:275380	5/21 (24%)
		LRR 7	158..180		1/21 (5%)
		leucine-rich repeat	159..181	CDD:275380	1/21 (5%)
		LRR 8	181..202		6/20 (30%)
		leucine-rich repeat	182..204	CDD:275380	6/21 (29%)
		LRR 9	204..226		3/26 (12%)
cyr1	NP_596159.1	Ad_cyc_g-alpha	155..200	CDD:129025
		UBQ	292..387	CDD:294102
		leucine-rich repeat	409..430	CDD:275380
		leucine-rich repeat	431..454	CDD:275380	2/5 (40%)
		LRR_RI	<441..616	CDD:238064	55/192 (29%)
		leucine-rich repeat	455..477	CDD:275380	4/21 (19%)
		LRR_8	476..537	CDD:290566	18/61 (30%)
		leucine-rich repeat	478..503	CDD:275380	6/24 (25%)
		leucine-rich repeat	504..526	CDD:275380	7/22 (32%)
		leucine-rich repeat	527..549	CDD:275380	9/21 (43%)
		LRR_8	548..607	CDD:290566	25/58 (43%)
		leucine-rich repeat	550..572	CDD:275380	8/21 (38%)
		leucine-rich repeat	573..596	CDD:275380	11/22 (50%)
		leucine-rich repeat	597..618	CDD:275380	6/44 (14%)
		leucine-rich repeat	661..684	CDD:275380	3/31 (10%)
		leucine-rich repeat	685..707	CDD:275380	3/30 (10%)
		leucine-rich repeat	708..730	CDD:275380	9/42 (21%)
		LRR_RI	<724..941	CDD:238064	4/14 (29%)
		leucine-rich repeat	754..783	CDD:275380
		leucine-rich repeat	784..807	CDD:275380
		leucine-rich repeat	808..831	CDD:275380
		LRR_8	832..889	CDD:290566
		leucine-rich repeat	832..855	CDD:275380
		leucine-rich repeat	856..877	CDD:275380
		leucine-rich repeat	879..901	CDD:275380
		leucine-rich repeat	902..930	CDD:275380
		PP2C	1032..1268	CDD:278884
		CYCc	1300..1488	CDD:214485
		Nucleotidyl_cyc_III	1323..1519	CDD:299850
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR45752
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100