DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Capn3 and CalpC

DIOPT Version :9

Sequence 1:	NP_031627.2	Gene:	Capn3 / 12335	MGIID:	107437	Length:	821	Species:	Mus musculus
Sequence 2:	NP_573118.2	Gene:	CalpC / 32597	FlyBaseID:	FBgn0260450	Length:	681	Species:	Drosophila melanogaster

Alignment Length:	792	Identity:	215/792 - (27%)
Similarity:	354/792 - (44%)	Gaps:	156/792 - (19%)

- Green bases have known domain annotations that are detailed below.

Mouse    61 FEQLRRKCLEKKVLYLDPEFPPDETSLFYSQKFPIQFVWKRPPEICEN------------PRFII 113
            :|::...|..|.||:.||:||..::|:||.|..|..|.|||..::.::            |.|:.
  Fly     5 YERILSDCRSKNVLWEDPDFPAVQSSVFYYQTPPFTFQWKRIMDLADSGSGAVAANSSAAPVFLN 69

Mouse   114 GGANRTDICQGDLGDCWFLAAIACLTLNERLLFRVIPHDQSFTENYAGIFHFQFWRYGDWVDVVI 178
            ..| ..|:..|.:||.|.::.:..|:....|.:||:|.||:....: |:|.|:.|..|:||:|::
  Fly    70 ESA-EFDVVPGKMGDRWLVSCLGLLSSLRNLFYRVVPADQTLASAH-GVFRFRLWWCGEWVEVLV 132

Mouse   179 DDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVTEFFEIKD 243
            ||.|||.|.:|.|.:....|.||:||||||.|||||||||||.|..::.:.|..|||     ::.
  Fly   133 DDRLPTINGRLAFMQPQASNCFWAALLEKAIAKLHGSYEALKYGTRSDGLTDLLGGV-----VRQ 192

Mouse   244 AP--SDMYK--IMRKAIERGSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRNMDNSLLRDSDL 304
            .|  ||..:  .:::.:....::.|..|
  Fly   193 MPILSDNIRPQTLKELLTTTCIVTCLAD------------------------------------- 220

Mouse   305 DPRGSDDRPSRTIVPVQYETRMACGLVKGHAYSVTGLEEA-LFKGEKVKLVRLRN-----PWGQ- 362
                    .|.|:.......||..|::....|.::.|::. ...|:.|:||.|::     |:|:
  Fly   221 --------KSATVAKKNLAERMPNGILVNVNYRLSSLDKVKTLMGDSVQLVCLKDTFSSKPFGEK 277

Mouse   363 VEWNGSWSDGWKDWSFVDKDEKARLQHQVTEDGEFWMSYDDFVYHFTKLEICNLTADALESDKLQ 427
            ..:.|.||...|.|..|.:.|:|||..|: ..||||:|:.|||..|:.:|:..|..:....:::.
  Fly   278 THFLGDWSPMSKTWERVSQVERARLIRQL-GPGEFWLSFCDFVEIFSTMEVVYLDTETSNDEEML 341

Mouse   428 T-----WTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPEDSEVICSFLVALMQK 487
            .     |.:.:::|:|.||.:||||||. ::|..|||..:.:.:|.|          .::||.|.
  Fly   342 KSRPLHWKMKMHQGQWKRGVTAGGCRNH-ESFHINPQLLISVQDEQD----------LVIALNQH 395

Mouse   488 NRRKDRKLGANLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPS 552
            ...:.:       .|||.:|....| :...:.||||||..:.|...| .|.|.|.||....|...
  Fly   396 TAVEPK-------VIGFTMYTWDGE-YMLSECLQKDFFKNHVSYLNS-DYGNTRHVSYHTHLEAG 451

Mouse   553 EYVIVPSTYEPHQEGEFILRVF--SEKRNLSEEAENTISVDRPVKKKKNKPIIFVSDRANSNKEL 615
            .||::|:||||.:|..|.:|:.  ...|....|.:..|.:|
  Fly   452 HYVLIPTTYEPAEEAHFTVRILGTGSFRLSCLETQTMILLD------------------------ 492

Mouse   616 GVDQEAEEGKDKAGPEKRGETPQPRPGHTDQES------EEQQQFRNIFRQIAGDDMEICADELK 674
                                 |.|....||.|.      :...|:..::.|:|.::..|...||.
  Fly   493 ---------------------PFPALKSTDAERCGGPKVKSVCQYEPVYMQLADENKTINCFELH 536

Mouse   675 NVLNTVVNKHKDLKTQGFTLESCRSMIALMDTDGSGRLNLQEFHHLWKKIKAWQKIFKHYDTDHS 739
            .:|...:  ..|.......::.||.:|||.|..||||:..|:|......:|:||.:||.|..:.:
  Fly   537 ELLEACL--PNDYIKGCANIDICRQVIALQDRSGSGRITFQQFKTFMVNLKSWQGVFKMYTKEKA 599

Mouse   740 GTINSYEMRNAVNDAGFHLNSQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFNAFDKDGD 804
            |.:.:..:|:|:.|.||.|::.:.:.:..||..|...:....|:...:.|...|..|:..:....
  Fly   600 GILRAERLRDALCDIGFQLSTDIMNCLIQRYIRKDGTLRLSDFVSAVIHLTTAFNQFHLKNYGQV 664

Mouse   805 GIIKLNVLEWLQ 816
            .:|::::.:|::
  Fly   665 NVIEVHLHDWIK 676

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Capn3	NP_031627.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..37
		Peptidase_C2	77..415	CDD:279042	109/360 (30%)
		Domain III	418..586		51/174 (29%)
		Calpain_III	429..579	CDD:279416	49/151 (32%)
		Calpain_u2	583..653	CDD:293254	8/75 (11%)
		Linker	587..649		7/67 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	603..651		5/53 (9%)
		Domain IV	650..820		42/167 (25%)
		EFh	653..722	CDD:238008	20/68 (29%)
		EFh	697..751	CDD:238008	20/53 (38%)
		EFh	728..817	CDD:298682	20/89 (22%)
		EF-hand_7	728..784	CDD:290234	15/55 (27%)
CalpC	NP_573118.2	CysPc	7..329	CDD:238004	113/374 (30%)
		Calpain_III	346..483	CDD:238132	50/156 (32%)
		FRQ1	<567..648	CDD:227455	23/80 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10183
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920