DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Camk2g and CaMKI

DIOPT Version :9

Sequence 1:	XP_006518551.1	Gene:	Camk2g / 12325	MGIID:	88259	Length:	588	Species:	Mus musculus
Sequence 2:	NP_524622.1	Gene:	CaMKI / 43792	FlyBaseID:	FBgn0016126	Length:	405	Species:	Drosophila melanogaster

Alignment Length:	415	Identity:	150/415 - (36%)
Similarity:	213/415 - (51%)	Gaps:	58/415 - (13%)

- Green bases have known domain annotations that are detailed below.

Mouse    12 DDYQLFEELGKGAFSVVRRCVKKTSTQE-YAAKIINTKKLSARDHQKLEREARICR--------- 66
            :.|.|...||.||||.||....|.|..| :|.|||:.|.|..:: :.||.|.|:.|
  Fly    29 EKYNLHGLLGTGAFSEVRLAESKDSPGEHFAVKIIDKKALKGKE-ESLENEIRVLRRFSANHFDG 92

Mouse    67 ------LLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVN 125
                  .|.|||||:|.::..::...|||.:||||||||:.||.:..|:|.||||.|.||||:|:
  Fly    93 KCLNGTRLTHPNIVQLLETYEDKSKVYLVMELVTGGELFDRIVEKGSYTEKDASHLIRQILEAVD 157

Mouse   126 HIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLA-IEVQGEQQAWFGFAGTPGYLSPEVLRKD 189
            ::|:..:|||||||||||..|....:.:.::||||: :|..|....   ..|||||::||||.:.
  Fly   158 YMHEQGVVHRDLKPENLLYYSPDDDSKIMISDFGLSKMEDSGIMAT---ACGTPGYVAPEVLAQK 219

Mouse   190 PYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLT 254
            ||||.||:|:.|||.||||.|||||:||:...|:.||..|.::|.||.||.::..||:.|..::.
  Fly   220 PYGKAVDVWSIGVISYILLCGYPPFYDENDANLFAQILKGDFEFDSPYWDEISESAKHFIKNLMC 284

Mouse   255 INPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSVGRQ 319
            :...||.|..|||.|.|:.....                  :.|.:.|.:  :..:.:||:..|.
  Fly   285 VTVEKRYTCKQALGHAWISGNEA------------------SSRNIHGTV--SEQLKKNFAKSRW 329

Mouse   320 SSAPASPAASAAGLAGQAAKSLLNKKSDGGVKKRKSSSSVHLMPQSNNKNSLVSPAQEPAPLQTA 384
            ..     |..||.:..|..:..||..|:.......||          |::|....|...|.....
  Fly   330 KQ-----AYYAATVIRQMQRMALNSNSNANFDSSNSS----------NQDSTTPTAATGAWTSNV 379

Mouse   385 MEPQTTVVHNATDGIK--GSTESCN 407
            :..|.:|..:|.:..|  |||.:.:
  Fly   380 LSSQQSVQSHAQEMNKSGGSTNAAS 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Camk2g	XP_006518551.1	STKc_CaMKII	12..303	CDD:270988	126/307 (41%)
Camk2g	XP_006518551.1	CaMKII_AD	456..583	CDD:285524
CaMKI	NP_524622.1	STKc_CaMKI	27..301	CDD:270985	124/275 (45%)
CaMKI	NP_524622.1	S_TKc	31..302	CDD:214567	124/274 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X46
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920