DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Aspm and asp

DIOPT Version :9

Sequence 1:NP_033921.3 Gene:Aspm / 12316 MGIID:1334448 Length:3122 Species:Mus musculus
Sequence 2:NP_524488.3 Gene:asp / 42946 FlyBaseID:FBgn0000140 Length:1954 Species:Drosophila melanogaster


Alignment Length:2710 Identity:587/2710 - (21%)
Similarity:1016/2710 - (37%) Gaps:886/2710 - (32%)


- Green bases have known domain annotations that are detailed below.


Mouse    16 RARPDPEAGDPSPPVLLLSHFCGVPFLCFGDVRVGTSRTRSLVLHNPHEEPLQVELSLLRAAGQG 80
            |.:....|....|.|::::.|.....:.|.||.:..:..|.:.:.||.::  .:|:.:::|..:.
  Fly    12 RLKQKKRAEGREPAVVVMAPFSAKAIVQFEDVPITKTARRQVRVLNPSDD--DIEVKVMKAIREE 74

Mouse    81 FSVAPNRCE--LKPKEKLTISVTWTPLREGGVREIVTFLVN-DFLKHQAILL-GNAEEPKKKKRS 141
            .:::....|  :..::::::.:.|:|:.|...:|.:..:.| :|.|...|:| ..:.:|.|..|.
  Fly    75 HNLSLEWMEHTVPARDEVSMELVWSPVLEVACKETLQLIDNRNFRKEVMIILKSKSNQPVKNPRK 139

Mouse   142 LWNTSK----KIPASSKHTKRTSKNQHFNESFTISQKDRIRSPLQPCENLAMSECSSPTEN---K 199
            .....|    |.|..:..|.::.      .|..:.||.|            ||..::|...   :
  Fly   140 FPTVGKTLQLKSPTGAGKTMKSV------VSAAVQQKKR------------MSAAAAPPSKQTWR 186

Mouse   200 VPTPSISPIRECQSETCLPLFLRESTAYSSLHE-----SENTQNLKVQDASISQTFDFNEEVANE 259
            |..|| .|..........||.  |...|.:..|     |...::|| ::.|.....:..:.:.|.
  Fly   187 VTAPS-RPAAWAHPPPQAPLV--EKNVYKTPQEEPVYISPQPRSLK-ENLSPMTPGNLLDVIDNL 247

Mouse   260 TFINPISVCHQSEGDRKLTLAPN--CSSPLNSTQTQIHFLSPDSFVNNRYTSDNDLKSMKNVLSD 322
            .| .|::   ::.|..:.|:.|:  .:.|..:.:..:...:.|  :..|..:.:||:. :...:.
  Fly   248 RF-TPLT---ETRGKGQATIFPDNLAAWPTPTLKGNVKSCAND--MRPRRITPDDLED-QPATNK 305

Mouse   323 TFRKDPAESVCLESQTVHEVCQTI-LSPDSFLNDNYGLKKGLNFKSV---------NPVLSPTQF 377
            ||....:|::.:...|:.  |..| ..|.:.||....:....:.:::         :|..:||:.
  Fly   306 TFDVKHSETINISLDTLD--CSRIDGQPHTPLNKTTTIVHATHTRALACIHEEEGPSPPRTPTKS 368

Mouse   378 ----VKDSMGHVGQQTGKSNEASQDWRINEGLAYTPECQHA---QTPSSRSEKQNPVEVKPHTYD 435
                :|..:..||....|.:|:.:|..:     .:|:.::|   ..|:....|...:|       
  Fly   369 AIHDLKRDIKLVGSPLRKYSESMKDLSL-----LSPQTKYAIQGSMPNLNEMKIRSIE------- 421

Mouse   436 FTKQKPKISEFQDAFCHQSKQPHKRRPILSATVTKRKPTNAREKL---PEINKPDAKRCLEGLVG 497
                       |:.:..:.:...|.:.:.|::.::......:|.|   .||....::..|.    
  Fly   422 -----------QNRYYQEQQIQIKAKDLNSSSSSEASLAGQQEFLFNHSEILAQSSRFNLH---- 471

Mouse   498 ERGKEVGSLREKGFHSSLPVVEPGVSKALSYRDEVTPATVVVARKRKSHG-TVGDA--NGKVAAE 559
                |||....||    .||..|                    .||:||. :..||  |..:...
  Fly   472 ----EVGRKSVKG----SPVKNP--------------------HKRRSHELSFSDAPSNESLYRN 508

Mouse   560 EWMDMCEVKRIHFSPLESTPSTVARTTKKEGHTSKRISS------LERSGLKKKMDSSILKTPLS 618
            |.:.:...|:      :....|....:....:.|.|.||      .:....|.....|::|.|.:
  Fly   509 ETVAISPPKK------QRVEDTTLPRSAAPANASARSSSAHAWPHAQSKKFKLAQTMSLMKKPAT 567

Mouse   619 KTKKKRRSI---VAVAQSHL---TFIKPLKAAIPRHPMPFAAKNMFYDERWKEKQEQGFTWWLNY 677
            ..|.:..||   |.:..|.|   |.|.|...|......||.|..|:.||:..::.:..|..|||.
  Fly   568 PRKVRDTSIQPSVKLYDSELYMQTCINPDPFAATTTIDPFLASTMYLDEQAVDRHQADFKKWLNA 632

Mouse   678 ILT-PDDFTVKTNVSKVNAASLVLGAESQHKISVPKAPTKEEVSLRAYTASCRLNRLRRTACSLF 741
            ::: |.|.....| :|::...|.....::..:   .||||||.|:. |....||..||:.|..||
  Fly   633 LVSIPADLDADLN-NKIDVGKLFNEVRNKELV---VAPTKEEQSMN-YLTKYRLETLRKAAVELF 692

Mouse   742 TSEKMVKAIKKVEIEIEVGRLLVRKDRHLWKDIGQRQKVLNWLLSYNPLWLRIGLETVFGELIPL 806
            .||:|.....||.:.:....|.:|.||:|..|:..::.:|..||.:||||||:|||.||||.|.:
  Fly   693 FSEQMRLPCSKVAVYVNKQALRIRSDRNLHLDVVMQRTILELLLCFNPLWLRLGLEVVFGEKIQM 757

Mouse   807 ADNSDVTGLAMFILNRLLWNPDIAAEYRHPTVPLLFRDGHEAALSKFTLKKLLLLICFLDHAKIS 871
            ..|.|:.||:.||||||..|.  ..|.|:.....|..: :...:.|.:|:|:|.|:.|||.||..
  Fly   758 QSNRDIVGLSTFILNRLFRNK--CEEQRYSKAYTLTEE-YAETIKKHSLQKILFLLLFLDQAKQK 819

Mouse   872 RLIDHDPCLFCKDAEFKASKELLLAFSRDFLSGEGDLSRHLSFLGLPVSHVQTPLDEFDFAVTNL 936
            |::.|:||||.|.:..|.:|::||.||.:.|:..||::|.|..||..:.|.||.|||||:|..||
  Fly   820 RIVKHNPCLFVKKSPHKETKDILLRFSSELLANIGDITRELRRLGYVLQHRQTFLDEFDYAFNNL 884

Mouse   937 AVDLQCGVRLVRTVELLTQNWNLSDKLRIPAISRVQKMHNVDLVLQVLKSRGVPLTDEHGSAISS 1001
            ||||:.||||.|.:|::....:|:.:||:|||||:|::.||.|.|..|......|    |..|::
  Fly   885 AVDLRDGVRLTRVMEVILLRDDLTRQLRVPAISRLQRIFNVKLALGALGEANFQL----GGDIAA 945

Mouse  1002 KDVVDRHREKTLGLLWKIALAFQVDISLNLDQLKEEIDFLKHTHSIKRAMSALTCPSQAITNKQR 1066
            :|:||.||||||.|||::...|:                                          
  Fly   946 QDIVDGHREKTLSLLWQLIYKFR------------------------------------------ 968

Mouse  1067 DKRISGNFERYGDSVQLLMDWVNAVCAFYNKKVENFTVSFSDGRILCYLIHHYHPCYVPFDAICQ 1131
                                                                             
  Fly   969 ----------------------------------------------------------------- 968

Mouse  1132 RTSQSVACAQTGSVVLNSSSESEGGCLDLSLEALDHESTPEMYKELLENEKKNFHLVRSAARDLG 1196
                                                  :|:            ||          
  Fly   969 --------------------------------------SPK------------FH---------- 973

Mouse  1197 GIPAMIHHSDMSNTIPDEKVVITYLSFLCARLLDLRKEIRAARLIQTTWRKYKL----KRDLKHH 1257
                                                   .||.::|..||::.|    :|.::| 
  Fly   974 ---------------------------------------AAATVLQKWWRRHWLHVVIQRRIRH- 998

Mouse  1258 QERDKAARVIQSVVLNFLSRRRLQKNVSAALVIQKCWRRVSAQRKLRMLKNEKLAKLQNKSAVLI 1322
                                :.|.:...||.|||..:|....::.:::.|.|:     .::|:::
  Fly   999 --------------------KELMRRHRAATVIQAVFRGHQMRKYVKLFKTER-----TQAAIIL 1038

Mouse  1323 QAYWRRYSTRKRFLRLKHYSVILQSRIRMKIALTSYKRYLWATVTIQRHWRAYLSRKRDQQIFRK 1387
            |.:.|||..:|:..:..|                       :.:||||.|||....::.:|.|.:
  Fly  1039 QKFTRRYLAQKQLYQSYH-----------------------SIITIQRWWRAQQLGRQHRQRFVE 1080

Mouse  1388 LKSSSLVIQFMFRRWKRRKLQLQTKAAVTLQRAFREWHLRKQIRERSAVVIQSWYRMHR----EL 1448
            |:.:::.:|   |.|:||....:..||....|.     .|.|.::.:|..||..:|.::    :.
  Fly  1081 LREAAIFLQ---RIWRRRLFAKKLLAAAETARL-----QRSQKQQAAASYIQMQWRSYQLGRIQR 1137

Mouse  1449 QKYIYIRSCVIVIQRRVRCFQAQKLYKRRKDAILTLQKHYRARQKGKLAHADYLQKRAATIRLQA 1513
            |:::..|..::.:|||:|                                               
  Fly  1138 QQFLRQRDLIMFVQRRMR----------------------------------------------- 1155

Mouse  1514 AFRGMKARHSYRLQIGAACVLQSYWRMRQERVRFLNLKKMVIKLQAHIRKYQQLQKYKKIKKAAI 1578
                                  |.|.|.::|                 :::|||      |:|||
  Fly  1156 ----------------------SKWSMLEQR-----------------KEFQQL------KRAAI 1175

Mouse  1579 TIQTHFRASISARRVLASYQKTRSSVIVLQSACRGMQARKAFRHALASVIKIQSYYRAYICRKTF 1643
            .||..:||.:|.|:..|.|...||||:.:|          |:|.|...:...:::|  |..||  
  Fly  1176 NIQQRWRAKLSMRKCNADYLALRSSVLKVQ----------AYRKATIQMRIDRNHY--YSLRK-- 1226

Mouse  1644 QNFKNATIKLQSIVKMKQSRKQYLQIRAAALFIQRWYRSQKLASQKRKEYIQVRESCIKLQSHFR 1708
             |......:|::|:||::.|:.||::|.|::.:|:.||.::...|.|..|::.|:..|.:|..:|
  Fly  1227 -NVICLQQRLRAIMKMREQRENYLRLRNASILVQKRYRMRQQMIQDRNAYLRTRKCIINVQRRWR 1290

Mouse  1709 GCLVRKQLRLQCKAAISLQSYFRMRTARQRYLKMCKAALVIQSFYCAYRAQISQRKNFLQVKRAA 1773
            ..|                   :||..|:.||.:......||..:.|.|....||..|||:|:..
  Fly  1291 ATL-------------------QMRRERKNYLHLQTTTKRIQIKFRAKREMKKQRAEFLQLKKVT 1336

Mouse  1774 ICLQAAYRGCKVRRQIKQQSTAAVTIQRVFRGHSQRMKYQTMLQSAVKIQRWYRAQKVAYDMRIQ 1838
            :.:|      |.||.:.|.             ..:|.:|..:.:..:|:||.:.|||....||.:
  Fly  1337 LVVQ------KRRRALLQM-------------RKERQEYLHLREVTIKLQRRFHAQKSMRFMRAK 1382

Mouse  1839 FLKTREAVVCLQSAYRGWQVRQQLRRQHEAAVKIQSTFRMAVAQQQYKLLRAAAAVIQQHVRARA 1903
            :..|:.||.|||..:|.                              .|||              
  Fly  1383 YRGTQAAVSCLQMHWRN------------------------------HLLR-------------- 1403

Mouse  1904 AGKRQHLAYIQLRHAALVFQAAWKGKMLRRQIARQHQCAALIQSYYRMHIQRRKWSIMKTAALQI 1968
              ||:..:::|||.||:..|..::.::                   .|..|.:.::.:|.||:.|
  Fly  1404 --KRERNSFLQLRQAAITLQRRYRARL-------------------NMIKQLKSYAQLKQAAITI 1447

Mouse  1969 QLCYRAYKVGKEQRHLYLKTKAAVVTLQSAYRG-MKVRKRVAECHKAAVTIQSKFRAYRTQKKYT 2032
            |..|||.|..::|..||.|.:.|::.:|..||| :::||::                    :.|.
  Fly  1448 QTRYRAKKAMQKQVVLYQKQREAIIKVQRRYRGNLEMRKQI--------------------EVYQ 1492

Mouse  2033 TYRTSAIVIQRWYRNIKITTQQHQEYLNLRRAAVQVQAAYRGIRVRRRIQHMHMAATLIEAMFKM 2097
            ..|.:.|.:|:|:|:|:                                              .|
  Fly  1493 KQRQAVIRLQKWWRSIR----------------------------------------------DM 1511

Mouse  2098 RQSRVRYLKMRTAALIIQVRYRAYYLGKIQHEKYLRTLKAIKTLQAGVRGARVRRTVRKMHFAAT 2162
            |..:..|.::|.::|.||.::||....:.|.|.:|.|::.::.:||.:|              ||
  Fly  1512 RLCKAGYRRIRLSSLSIQRKWRATVQARRQREIFLSTIRKVRLMQAFIR--------------AT 1562

Mouse  2163 LIQSHFRGHRQQTYFHRLRKAATMVQQRYRAVKEGSAEFQRYSRLRRSVLLIQAAFRGLRTRRHL 2227
            |:.     .:|:..|...|:||.::|:|:||........|.|..::.||:|:|..||..|:.:. 
  Fly  1563 LLM-----RQQRREFEMKRRAAVVIQRRFRARCAMLKARQDYQLIQSSVILVQRKFRANRSMKQ- 1621

Mouse  2228 KAMHLAATLIQRRFRTFAMRRKFLSLRKTAIWIQRQYRA-RLYAKYSRQQLLLEKAVIKIQSSYR 2291
                              .|::|:.||..|:.:|:::|. ||..:......||..::...|:..|
  Fly  1622 ------------------ARQEFVQLRTIAVHLQQKFRGKRLMIEQRNCFQLLRCSMPGFQARAR 1668

Mouse  2292 GWVVRKRVQKMHRAATVIQATFRMHGAYMRYQHLKRASVVIQVHTAAELQRQKHAAVILQAAVRG 2356
            |::.|||.|                              .:......:|.|||.||.:       
  Fly  1669 GFMARKRFQ------------------------------ALMTPEMMDLIRQKRAAKV------- 1696

Mouse  2357 MKTRSHLKTMHSSATLIQSQFRAFIVRRRFIALRKAAIFVQRKFRATLYAKHKLHQFLQLRKAAI 2421
                            ||..:|.:::|||            :|.:..|..:.::   .|||:.|.
  Fly  1697 ----------------IQRYWRGYLIRRR------------QKHQGLLDIRKRI---AQLRQEAK 1730

Mouse  2422 TIQSSYRRLMVQKKLQEMHR----------AAALIQATFRMHRTYVAFHIWKCASIRIQQCYRTY 2476
            .:.|      |:.|:||..|          |.|::....|:.||.....:| |:......||...
  Fly  1731 AVNS------VRCKVQEAVRFLRGRFIASDALAVLSRLDRLSRTVPHLLMW-CSEFMSTFCYGIM 1788

Mouse  2477 -RTIKLQKEK-LIREEQHSAAVLIQSTYRMYRQRCFYQ---------QRRWAAK----------V 2520
             :.|:.:.:| ||  |:.|..:|..:.|.......|.:         ..||..|          :
  Fly  1789 AQAIRSEVDKQLI--ERCSRIILNLARYNSTTVNTFQEGGLVTIAQMLLRWCDKDSEIFNTLCTL 1851

Mouse  2521 IQKTYRANKRRQ---------DLLYVCKEETPLLQMHFQGLNTAKQGRQQHGAAM---ITQKHFR 2573
            |.......|:|:         :.:|:.:|...|:         |::.:.:..|..   :|...::
  Fly  1852 IWVFAHCPKKRKIIHDYMTNPEAIYMVRETKKLV---------ARKEKMKQNARKPPPMTSGRYK 1907

Mouse  2574 A----FKARRLMEAERGFQAGCRKYKAKKYLSKVEA----ACRIQ 2610
            :    |....|...|..|  |..:|....::|.|.|    .|::|
  Fly  1908 SQKINFTPCSLPSLEPDF--GIIRYSPYTFISSVYAFDTILCKLQ 1950

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AspmNP_033921.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..26 2/9 (22%)
ASH 29..126 CDD:292408 18/99 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 139..169 5/33 (15%)
Sufficient for interaction with KATNA1:KATNB1. /evidence=ECO:0000269|PubMed:28436967 289..388 19/112 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 579..600 5/26 (19%)
CH 928..1024 CDD:294029 45/95 (47%)
CH 1082..>1135 CDD:278723 0/52 (0%)
aspNP_524488.3 ASH 26..122 CDD:292408 18/97 (19%)
CH 866..968 CDD:237981 50/105 (48%)
TPH 1066..1435 CDD:290579 127/586 (22%)
IQ 1689..1711 CDD:197470 11/56 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167835916
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0165
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S8171
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0005407
OrthoInspector 1 1.000 - - oto92808
orthoMCL 1 0.900 - - OOG6_104698
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3494
SonicParanoid 1 1.000 - - X4974
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
109.580

Return to query results.
Submit another query.