DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cacna2d3 and CG4587

DIOPT Version :9

Sequence 1:	NP_033915.1	Gene:	Cacna2d3 / 12294	MGIID:	1338890	Length:	1091	Species:	Mus musculus
Sequence 2:	NP_001188817.2	Gene:	CG4587 / 34921	FlyBaseID:	FBgn0028863	Length:	1271	Species:	Drosophila melanogaster

Alignment Length:	1271	Identity:	368/1271 - (28%)
Similarity:	592/1271 - (46%)	Gaps:	266/1271 - (20%)

- Green bases have known domain annotations that are detailed below.

Mouse    23 LYAALGDVVRSEQQIPLSVVKLWASAFGGEIKSIAAKYSGSQLLQKKYKEYEKDVAIEEIDGLQL 87
            ::.|..|   .::.||.:.|:.||..||.::.....:::....::.::|  :.|:.::..||:.|
  Fly    23 IFVAFAD---QDEDIPHNEVRNWALKFGVDLWEFGRQFTKMNEIKSRFK--DNDIEVKRKDGIIL 82

Mouse    88 VKKLAKIMEEMFHKKSEAVRRLVEAAEEAHLKHEFDADLQYE-------YFNAVLINERDKDGNF 145
            :::||..::.....|..||.||:::||:|.|. |.:...|.|       :::|..|||.:.||..
  Fly    83 LRELAAEVKNFMDFKRNAVMRLMDSAEQAALS-ELEGQGQAESPMGGQQHYDARRINEYNADGKL 146

Mouse   146 LELGKEFILAPNDHFNNLPVNISLSDVQVPTNMYNKDPAIVNGVYWSESLNKVFVDNFDRDPSLI 210
            .:..:...:.....|..||||:|||.:.||..:...:|.:.:.:.||..|:.:|.:|.::||:|.
  Fly   147 ADGARHMDIRFMRRFERLPVNLSLSSILVPHGVDLDEPDVKSALQWSGHLDPLFQNNLEQDPALS 211

Mouse   211 WQYFGSAKGFFRQYPGIKWEPD--ENGVIAFDCRNRKWYIQAATSPKDVVILVDVSGSMKGLRLT 273
            ||||||:.||.|::||..|.|:  :...:..|.|...|::|||:||||::||:|.|.||......
  Fly   212 WQYFGSSTGFLRRFPGTAWPPEGSKGSKLIHDFRTHNWFVQAASSPKDIMILLDASSSMTEKSFD 276

Mouse   274 IAKQTVSSILDTLGDDDFFNIITYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIGML 338
            :...|..:||||||:|||.|:||::|.:....||....:|:|...|.:..     |...|.|.:.
  Fly   277 LGMATAFNILDTLGEDDFVNLITFSEVVKTPVPCFKDRMVRATPDNIQEI-----KSAVKAIKLQ 336

Mouse   339 DIA-----LNEAFNILSDFNHTGQGSICSQAIMLITDGAVDTYDTIFAKYNWPDRKVRIFTYLIG 398
            |.|     |..||::|..:|.:|.||.|:|||||||:...:::..:..:||||...|||||||||
  Fly   337 DTANFTAGLEYAFSLLHKYNQSGAGSQCNQAIMLITESTSESHKDVIKQYNWPHMPVRIFTYLIG 401

Mouse   399 REAAFADNLKWMACANKGFFTQISTLADVQENVMEYLHVLSRPKVIDQ-EHDVVWTEAYI----- 457
            .::....||..|||:|||||.||:...:.:..|::|..|::||.::.| :|.|.|:..::
  Fly   402 SDSGSRSNLHDMACSNKGFFVQINDYDEARRKVIDYALVMARPMIMYQADHPVHWSPVFVAGKSG 466

Mouse   458 ----DSTLPQAQKLADDQGLVLMTTVAMPVFSKQNETRSKGILLGVVGTDVPVKELLKTIPKYKL 518
                ||...:.          |:|||:.|||.::|.:.....||||||||||::|:.|.||::||
  Fly   467 GLGRDSEYQRR----------LVTTVSTPVFDRRNHSVRVANLLGVVGTDVPIEEIRKVIPQHKL 521

Mouse   519 GIHGYAFAITNNGYILTHPELRPLYEEGK--KRRKPNYSSVDLSEVEWEDRD------------- 568
            |.:||:|.:.|||.:|.||:||||.:..:  .:.||.|:|||::|:|..:.:
  Fly   522 GPNGYSFIVDNNGRVLYHPDLRPLGDANQYIDQLKPKYASVDITELELPETEFGNNNEPIEINKN 586

Mouse   569 --DVLRNAMVNRKTGKFSMEVKKTVDKGKRVLVMTNDYYYTDIKGTPFSLGVALSRGHGKYFF-- 629
              :.:|..|:..|.|:....|....|..|||...|:.|:|..|:.|||:|.:.|...:|.:.|
  Fly   587 LLNEMRGDMIKPKEGETEFTVMNHYDDSKRVSTRTHRYFYGPIEDTPFTLAIVLPEKYGSHEFVS 651

Mouse   630 -------RGNVT-IEEGLHDLEHPDVSLADEWSYCN----TDL---------------------- 660
                   |.||| ..:|.:...|||      |.||.    :||
  Fly   652 QQEIRHSRNNVTEYFKGDNWRVHPD------WVYCEYNSVSDLEKERESSGEYSSRDQEPSFGSP 710

Mouse   661 --------------------------HPEHR--------------HLSQLEAIKLYLKGKEPLLQ 685
                                      .|.|.              |...........:..||..
  Fly   711 EEQVLHFLSRAGRPGWKWMSVRPKSPQPHHNMHSGSNGGNAPGSSHFGSQHQSSQGSRKAEPYF- 774

Mouse   686 CDKELIQEVLFDAVVSAPIEAYWTS--------------LALNKSENSDK-GVEVAFLGTRTGLS 735
            ||:.|:|.::.||:|:..::...|.              :|:.|.:...| .|..:|:.||:||.
  Fly   775 CDRALLQSLVRDAMVTDGLDRNTTGSSSGKEDKHPIATLMAILKRQGYQKFVVATSFVATRSGLL 839

Mouse   736 RINLFVGAEQLT-----NQDFLKAGDKENIFNADHFPLWYRRAAEQIA---GSFVYSIPFSTGTV 792
            |....|...:.|     ::|.::|.|..          ||:||.:|.:   .|||||:||.:|..
  Fly   840 RWIDHVKRPEDTPEPHFSEDNVRAMDTS----------WYKRAIDQHSVEPDSFVYSVPFGSGYA 894

Mouse   793 NKSN--VVTASTSIQLLDERKSPVVAAVGIQMKLEFFQRKFWTASRQCASLDGKCSISCDDETVN 855
            .|||  :||||.:|.:...........||:|.:.:...:.|...:..|..:.| |..:|..:.::
  Fly   895 IKSNATLVTASHAIFVEHRGHKAAAGVVGLQFQHDSLAKHFINITSACTGMTG-CKRTCASDNLD 958

Mouse   856 CYLIDNNGFILVSEDYTQTGDFFGEVEGAVMNKLLTMGSFKRITLYDYQAMCRANKESSDSAHGL 920
            ||::||:||:::||:...||.|||:::|.:|:.|:....:||:|:.|||.:|........:|.|:
  Fly   959 CYVLDNSGFVIISEEMEHTGKFFGQIDGTIMDSLVQDRIYKRVTVNDYQGVCSDADNPYTAAGGI 1023

Mouse   921 LDPYKAFLSAAKWIMTELV------LFLVEFNLCSWWHSDMT----------------------- 956
            |.|.:    ...|....|:      |.|:..:|.:|...:.|
  Fly  1024 LKPNR----LGSWFFNHLLALSAAWLSLMPASLRAWPQEEYTYDNEDVVFVDNNYSDEYEFGNEN 1084

Mouse   957 ----AKAQKLKQTLEPCDTEY-------------PAFVSE---------RT-------------- 981
                ...|::.:.....|.||             |.|..:         ||
  Fly  1085 EYNMQVDQEMDEFFTTADVEYTTPPPRQHKPHVGPRFSPDPHNARRCDLRTDLYMLQPERLNQGG 1149

Mouse   982 ----IKETTGNIACEDCSKSFVIQQIPSSNLFMVVVDSSCLCES----VAPITMAPIEIRYNESL 1038
                :|....|.....|.:.|.:|:||.|||.::|||:.|.|.|    :.|:..|.:   .....
  Fly  1150 QNNPLKGKLTNCHVSGCERPFSVQKIPHSNLILLVVDTLCPCGSKQLDIEPLEEAGV---IGACS 1211

Mouse  1039 KCERLKAQKIRRRPESCHGFHPEE-NARECGGASSL 1073
            ...:.:.|:.||||:.|..:|||| ..::||..|:|
  Fly  1212 TRRQGQEQESRRRPKKCINYHPEEIEIQQCGRGSTL 1247

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cacna2d3	NP_033915.1	VWA_N	113..229	CDD:285584	43/122 (35%)
		vWA_VGCC_like	242..425	CDD:238740	80/187 (43%)
		MIDAS-like motif	262..266		2/3 (67%)
		Cache_1	452..548	CDD:280839	41/106 (39%)
		VGCC_alpha2	561..633	CDD:285647	23/95 (24%)
CG4587	NP_001188817.2	VWA_N	108..230	CDD:285584	43/122 (35%)
		vWA_VGCC_like	245..428	CDD:238740	80/187 (43%)
		Cache_1	456..544	CDD:280839	38/97 (39%)
		VGCC_alpha2	590..>647	CDD:285647	19/56 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	129	1.000	Domainoid score	I5222
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	577	1.000	Inparanoid score	I1031
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110668at33208
OrthoFinder	1	1.000	-	-		FOG0000496
OrthoInspector	1	1.000	-	-		mtm8846
orthoMCL	1	0.900	-	-		OOG6_103783
Panther	1	1.100	-	-	O	PTHR10166
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X365
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.970