Protein Alignment Cacna2d1 and CG4587

DIOPT Version :9

• Sequence 1: XP_011248046.1
• Gene: Cacna2d1 / 12293
• MGIID: 88295
• Length: 1110
• Species: Mus musculus
• Sequence 2: NP_001188817.2
• Gene: CG4587 / 34921
• FlyBaseID: FBgn0028863
• Length: 1271
• Species: Drosophila melanogaster
• Alignment Length: 1315
• Identity: 321/1315 - (24%)
• Similarity: 551/1315 - (41%)
• Gaps: 310/1315 - (23%)

Mouse     5 CLLALTL--TLFQSGLIGPSSEEPFPSPVT-IKSWVDKMQEDLVTLAKTASGVTQLADIYEKYQ- 65
            |.:|:.|  .:|:..:....:::....|.. :::|..|...||....:.   .|::.:|..:::
  Fly     8 CFVAIVLGVLIFKMHIFVAFADQDEDIPHNEVRNWALKFGVDLWEFGRQ---FTKMNEIKSRFKD 69

Mouse    66 -DLYTVEPNNARQLVEIAARDIEKLLSNRSKALVRLAMEAE-----------KVQAAHQWREDFA 118
             |:.....:....|.|:|| :::..:..:..|::||...||           :.::....::.:.
  Fly    70 NDIEVKRKDGIILLRELAA-EVKNFMDFKRNAVMRLMDSAEQAALSELEGQGQAESPMGGQQHYD 133

Mouse   119 SNEVVYYNAKDDLDPERNESEPGSQRIKPVFIEDANFGRQ-----ISYQHAAVHIPTDIYEGSTI 178
            :..:..|||...|       ..|::.:      |..|.|:     ::...:::.:|..:......
  Fly   134 ARRINEYNADGKL-------ADGARHM------DIRFMRRFERLPVNLSLSSILVPHGVDLDEPD 185

Mouse   179 VLNELNWTSALDEVFKRNRDEDPTLLWQVFGSATGLARYYPASPWVDNSRTPNKIDLYDVRRRPW 243
            |.:.|.|:..||.:|:.|.::||.|.||.|||:||..|.:|.:.|.......:|: ::|.|...|
  Fly   186 VKSALQWSGHLDPLFQNNLEQDPALSWQYFGSSTGFLRRFPGTAWPPEGSKGSKL-IHDFRTHNW 249

Mouse   244 YIQGAASPKDMLILVDVSGSVSGLTLKLIRTSVSEMLETLSDDDFVNVASFNSNAQ-DVSCFQ-H 306
            ::|.|:||||::||:|.|.|::..:..|...:...:|:||.:|||||:.:|:...: .|.||: .
  Fly   250 FVQAASSPKDIMILLDASSSMTEKSFDLGMATAFNILDTLGEDDFVNLITFSEVVKTPVPCFKDR 314

Mouse   307 LVQANVRNKKVLKDAVNNITAKGITDYKKGFSFAFEQLLNYNVSRA--NCNKIIMLFTDGGEERA 369
            :|:|...|.:.:|.||..|..:...::..|..:||..|..||.|.|  .||:.|||.|:...|..
  Fly   315 MVRATPDNIQEIKSAVKAIKLQDTANFTAGLEYAFSLLHKYNQSGAGSQCNQAIMLITESTSESH 379

Mouse   370 QEIFAKYN-KDKKVRVFTFSVGQHNYDRGPIQWMACENKGYYYEIPSIGAIRINTQEYLDVLGRP 433
            :::..:|| ....||:||:.:|..:..|..:..|||.|||::.:|......|....:|..|:.||
  Fly   380 KDVIKQYNWPHMPVRIFTYLIGSDSGSRSNLHDMACSNKGFFVQINDYDEARRKVIDYALVMARP 444

Mouse   434 MVLAGDKAKQVQWTNVYLDALELG----------LVITGTLPVFNVTGQSENKTNLKNQLILGVM 488
            |::. .....|.|:.|::.....|          ||.|.:.|||:....|....||     |||:
  Fly   445 MIMY-QADHPVHWSPVFVAGKSGGLGRDSEYQRRLVTTVSTPVFDRRNHSVRVANL-----LGVV 503

Mouse   489 GVDVSLEDIKRLTPRFTLCPNGYYFAIDPNGYVLLHPNLQP-----------KP--IGVGIPTIN 540
            |.||.:|:|:::.|:..|.||||.|.:|.||.||.||:|:|           ||  ..|.|..:.
  Fly   504 GTDVPIEEIRKVIPQHKLGPNGYSFIVDNNGRVLYHPDLRPLGDANQYIDQLKPKYASVDITELE 568

Mouse   541 LRKRRPNVQNPKSQEPVTLDFLDAELENEIKVEIRNKMIDGESGEKTFRTLVKSQDERYIDKGNR 605
            |    |..:...:.||:       |:...:..|:|..||..:.||..|..:....|.:.:.....
  Fly   569 L----PETEFGNNNEPI-------EINKNLLNEMRGDMIKPKEGETEFTVMNHYDDSKRVSTRTH 622

Mouse   606 TYTWTPVNGTDYSLALVLPTYSFYYIKAKLEETITQARSKKGKMKDSETLKPDNF---------- 660
            .|.:.|:..|.::||:|||.      |....|.::|...:..:...:|..|.||:
  Fly   623 RYFYGPIEDTPFTLAIVLPE------KYGSHEFVSQQEIRHSRNNVTEYFKGDNWRVHPDWVYCE 681

Mouse   661 -----------EESGYTFIAPREYCN-DLKPS-DNNTEFLLNFNEFIDR----------KTP--- 699
                       |.||       ||.: |.:|| .:..|.:|:|.....|          |:|
  Fly   682 YNSVSDLEKERESSG-------EYSSRDQEPSFGSPEEQVLHFLSRAGRPGWKWMSVRPKSPQPH 739

Mouse   700 ----------NNPS---------------------CNTDLINRILLDAGFTNELVQNYWSK---- 729
                      |.|.                     |:..|:..::.||..|:.|.:|....
  Fly   740 HNMHSGSNGGNAPGSSHFGSQHQSSQGSRKAEPYFCDRALLQSLVRDAMVTDGLDRNTTGSSSGK 804

Mouse   730 ------------------QKNIKGVKARFVVTDGGITR-----VYPKEAGENW--QENPETYEDS 769
                              ||.:  |...||.|..|:.|     ..|::..|..  ::|....:.|
  Fly   805 EDKHPIATLMAILKRQGYQKFV--VATSFVATRSGLLRWIDHVKRPEDTPEPHFSEDNVRAMDTS 867

Mouse   770 FYKRSLDN-----DNYVFTAPYFNKSGPGAYESGIMVSKAVELYIQGKLLKPA--VVGIKIDVNS 827
            :|||::|.     |::|::.|:  .||.....:..:|:.:..::::.:..|.|  |||::...:|
  Fly   868 WYKRAIDQHSVEPDSFVYSVPF--GSGYAIKSNATLVTASHAIFVEHRGHKAAAGVVGLQFQHDS 930

Mouse   828 WIENFTKTSIRDPCAGPVCDCKRN--SDVMDCVILDDGGFLLMANHDDYTNQIGRFFGEIDPSMM 890
            ..::|  .:|...|.| :..|||.  ||.:||.:||:.||::::...::|   |:|||:||.::|
  Fly   931 LAKHF--INITSACTG-MTGCKRTCASDNLDCYVLDNSGFVIISEEMEHT---GKFFGQIDGTIM 989

Mouse   891 RHLVNISLYAFNKSYDYQSVCDPGAAPKQGAGHRSAYVPSIADILQIGWW------ATAAAWSIL 949
            ..||...:|......|||.||.....|...||       .|....::|.|      |.:|||
  Fly   990 DSLVQDRIYKRVTVNDYQGVCSDADNPYTAAG-------GILKPNRLGSWFFNHLLALSAAW--- 1044

Mouse   950 QQLLLSLTFPRLLEA-----------------------------------VEMEEDDF--TASL- 976
                ||| .|..|.|                                   |:.|.|:|  ||.:
  Fly  1045 ----LSL-MPASLRAWPQEEYTYDNEDVVFVDNNYSDEYEFGNENEYNMQVDQEMDEFFTTADVE 1104

Mouse   977 ----------------------SKQSCITEQTQYFFKNDTKSFSG--------LLDC--GNCSRI 1009
                                  :.:.|......|..:.:..:..|        |.:|  ..|.|.
  Fly  1105 YTTPPPRQHKPHVGPRFSPDPHNARRCDLRTDLYMLQPERLNQGGQNNPLKGKLTNCHVSGCERP 1169

Mouse  1010 FHVEKLMNTNLVFIMVESKGTCPCDTRLL-MQAEQTSDGPDPCDMVKQ---PRYRKGPDVCFDNN 1070
            |.|:|:.::||:.::|::  .|||.::.| ::..:.:.....|...:|   ...|:.|..|.:.:
  Fly  1170 FSVQKIPHSNLILLVVDT--LCPCGSKQLDIEPLEEAGVIGACSTRRQGQEQESRRRPKKCINYH 1232

Mouse  1071 VLE-DYTDCGGVSGL 1084
            ..| :...||..|.|
  Fly  1233 PEEIEIQQCGRGSTL 1247

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cacna2d1	XP_011248046.1	VWA_N	104..223	CDD:369855	30/134 (22%)
		vWA_VGCC_like	239..417	CDD:238740	63/182 (35%)
		dCache_1	<437..622	CDD:376917	59/207 (29%)
		VGCC_alpha2	651..1079	CDD:369894	131/613 (21%)
CG4587	NP_001188817.2	VWA_N	108..230	CDD:285584	30/134 (22%)
		vWA_VGCC_like	245..428	CDD:238740	63/182 (35%)
		Cache_1	456..544	CDD:280839	35/92 (38%)
		VGCC_alpha2	590..>647	CDD:285647	17/62 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000496
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10166
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X365
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.010