DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cacna1s and NaCP60E

DIOPT Version :9

Sequence 1:NP_001074492.1 Gene:Cacna1s / 12292 MGIID:88294 Length:1852 Species:Mus musculus
Sequence 2:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster


Alignment Length:2870 Identity:560/2870 - (19%)
Similarity:944/2870 - (32%) Gaps:1238/2870 - (43%)


- Green bases have known domain annotations that are detailed below.


Mouse    29 RALFCLTLQNPLRKACISIVEWKPFETIILLTIFANCVALAVYLPMPEDDNNTLNLGLEKLEYFF 93
            ::||.....:|.|:.|:.|...:.|:..::.||..||    ::|.|.|.        :|:.||.|
  Fly   104 KSLFLFYPWSPARRVCVYIATNQFFDYCVMATILFNC----IFLAMTET--------VEEAEYIF 156

Mouse    94 LIVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFIIVFLGVFTVILEQVNIIQTNTAPMSSKGAG 158
            |.::|||..:||||.|||.::..|||:.||.|||:::..|..|:.:|..|:            ||
  Fly   157 LAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSGYATIGMEVGNL------------AG 209

Mouse   159 LDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMH 223
                 ||.|||||.|:.||.:|.|:.::|::..:...|..:..|.:|.::::|:..|:::.|::.
  Fly   210 -----LRTFRVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQVYMGELR 269

Mouse   224 KTC------------------YFIGTDIVATVENEKPSPCARTGSGRPCTINGSECRGGWPGPNH 270
            ..|                  :...||.....|:|.|..|......|.|... ..|......|||
  Fly   270 NKCVRQVPTDWTNVSHTDWQIWVNDTDNWLYDEDELPVLCGNLTGARHCPFE-YVCLCVGENPNH 333

Mouse   271 GITHFDNFGFSMLTVYQCISMEGWTDVLYWVNDAIGNEWPW--IYFVTLILLGSFFILNLVL--- 330
            |.|:||||.:||||.:|.|:::.|.:|...|....|   |.  .:|..::..|||:::||:|   
  Fly   334 GYTNFDNFMWSMLTTFQLITLDYWENVYNMVLATCG---PMSVSFFTVVVFFGSFYLINLMLAVV 395

Mouse   331 ----------------------------------------------------GVLSGEFTKEREK 343
                                                                |||...::|::.:
  Fly   396 ALSYEEEAEITNEERKKDLLDHRDDSTFSFDPSVLNVKKLNKNNKKKIDSRKGVLLASYSKKKTR 460

Mouse   344 AK----------------SRG---------------------------TFQKLREKQQLEE---- 361
            .|                |.|                           |.|..::.||:|:    
  Fly   461 RKKTKGGKEGGTNGNGNGSNGDDNKSHSATPSPGPSPRHSATERPSALTMQAQKQYQQMEQQHKL 525

Mouse   362 --------------------------------------DLRGYM-----------SWITQGEVMD 377
                                                  |.:|.:           |.:.:....|
  Fly   526 AKSGSGGSNNPMAPTPKGRISFQDSGMGVKNPNMLYPSDYKGQLIANSGQPSSNSSGVNRESSQD 590

Mouse   378 ----VDDLREGKLSLDEGGSDTESL---------------------YEIEGLNK-------IIQF 410
                |||..|...:.|.|...|..|                     :.:..|::       :|..
  Fly   591 DSGVVDDHEEQDTTNDMGHVSTVELALSPREVRLIKCNGNIARIKNHNVYALHQEFSSEVVVIDD 655

Mouse   411 IRHWRQWNRVFRWKCHD-------------LVKSKVFYWLVILIVALNTLSIASEHHNQPLWLTH 462
            :.. |..:|...| |.|             :|:..:|...:.|.:.|||..:|.|||.......:
  Fly   656 LPD-RNCDRCVHW-CTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSESFRN 718

Mouse   463 LQDVANRVLLTLFTIEMLMKMYGLGLRQYFMSIFNRFDCFVVCSGILEIL--LVESGAMSPLGIS 525
            ..||.|:|..::||.|.::|:..|. :.:|:..:|.||..:|.:.:|:|:  ||:       |:|
  Fly   719 ALDVGNKVFTSIFTFECIVKLMALS-KDFFLCGWNIFDLLIVTASLLDIIFELVD-------GLS 775

Mouse   526 VLRCIRLLRLFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIIIFALLGMQLFGGRY---DF 587
            |||.:||||:.|:.:.||::..|::.::::|.::.:|.|:|.:.|.|||::|||||...|   .|
  Fly   776 VLRGLRLLRVLKLAQSWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDYTPEKF 840

Mouse   588 EDTEVRRSNFDNFPQALISVFQVLTGEDWNSVMYNGIMAYGGPTYPGVLVCI-YFIILFVCGNYI 651
            :...|.|.||::|..:.:.:|::|.|| |...:::.:.|   ....|...|. .|:...|.||::
  Fly   841 DPDPVPRWNFNDFFHSFMMIFRILCGE-WIEPLWDCMRA---EEEQGASTCFAIFLPTLVMGNFM 901

Mouse   652 LLNVFLAIAVDNLAEAESLTSAQ--------------------KAKAEERKRRK----------- 685
            :||:|||:.: |...:|.|.|.:                    :.|.:|||.||           
  Fly   902 VLNLFLALLL-NSFNSEELKSKKEEVGEESKLARSIERVRDLIRKKRQERKDRKERKFAEKFQQI 965

Mouse   686 -------------------MSKG------------------------------------------ 689
                               :.:|                                          
  Fly   966 VLDAQQAHAQTLSHQAAVGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTI 1030

Mouse   690 ----------------------LPDKSE------------------------------------- 695
                                  ||..|:                                     
  Fly  1031 VDGLEYDDTGDLPEQIQLQAHPLPPTSDSMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQAE 1095

Mouse   696 ------------------EERATVT---------------------------------------- 702
                              .|.||.|                                        
  Fly  1096 RRLQHQISSGVSTQQYDSREEATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSR 1160

Mouse   703 --------------------------KKLEQKSKGEGIPTTAKLKIDE----------------- 724
                                      |.|::.|:..|....:.||.:|                 
  Fly  1161 RYGSEEHDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSI 1225

Mouse   725 ----------------------------------------------------------------- 724
                                                                             
  Fly  1226 EQDELLSQQGNLREELLNCDQKELFQFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQPENETMV 1290

Mouse   725 -----------FESNVNEVK--------------DPYPSAD------------FPGDDEE---DE 749
                       ||..:.|:|              :|.|:||            ..|..|.   ||
  Fly  1291 EHSEFDNIIQSFEKELEEIKRSTTSLERKLSNLSEPSPAADEATKAIMEHIAIITGASERSAADE 1355

Mouse   750 PEIPVSP---------------------------------------------------------- 756
            ..:|::|                                                          
  Fly  1356 VVLPLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQIHAP 1420

Mouse   757 -----------------------------------------------------RPRPLAELQL-- 766
                                                                 ..:|::.|::  
  Fly  1421 FVAMEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRIES 1485

Mouse   767 ---------------------------------KEK----------------------------- 769
                                             |:|                             
  Fly  1486 EKMPRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVPATPPTSLKSSIEPPTLAQI 1550

Mouse   770 -------------------------AVPIP----------------------------------- 774
                                     |.|.|                                   
  Fly  1551 SSLKTTPPLAALTEHQQHFHATSIQAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQ 1615

Mouse   775 ------------EASS------------------------------------------------- 778
                        :|||                                                 
  Fly  1616 SARTESHSSGAADASSALALAMAQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLTVGG 1680

Mouse   779 -------------------------------------FFIFSP-------------TNKIRVLCH 793
                                                 |:...|             ..::|....
  Fly  1681 RRNSQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFMSCMDTQSAKHWTRVRTAVL 1745

Mouse   794 RIVNATWFTNFILLFILLSSAALAAEDPIRADSMR--NQILEYFDYVFTAVFTVEIVLKMTTYGA 856
            .:|:...|..|:|:.|..||..|..|| |..|..:  .::|.:.::.|..:|.||::||....|.
  Fly  1746 TVVDTPAFEWFVLVLIFASSITLCFED-INLDKNKTLKRVLYWINFSFCLIFVVEMILKWLALGF 1809

Mouse   857 FLHKGSFCRNYFNILDLLVVAVSLISMGLESSA-ISVVKILRVLRVLRPLRAINRAKGLKHVVQC 920
                ..:..:::.|||.::|.||:.|:.:|.:. :.|::.||.||.|||||||:|.:|::.||..
  Fly  1810 ----SKYFTSFWTILDFIIVFVSVFSLLIEENENLKVLRSLRTLRALRPLRAISRWQGMRIVVNA 1870

Mouse   921 VFVAIRTIGNIVLVTTLLQFMFACIGVQLFKGKFYSC----NDLSKMTEE----ECRGYYYIYKD 977
            :..||.:|.|::||..:...:|:.:|||.|.|||:.|    .:|..:||.    :|....|    
  Fly  1871 LMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVNEMGELLPITEVNDKWDCIEQNY---- 1931

Mouse   978 GDPTQIELRPRQWIHNDFHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNEEDTGPVYNNRVEMA 1042
                       .||::...||:|....::|..|:|||||.:::..|:|:...|..|.....:...
  Fly  1932 -----------TWINSKITFDHVGMGYLALLQVATFEGWMEVMADAVDARGVDLQPQREANLYAY 1985

Mouse  1043 IFFIIYIILIAFFMMNIFVGFVIVTFQ------EQGETEYKNCELDKNQRQCVQYALKARPLRCY 1101
            |:|:|:|:..:||.:|:|:|.:|..|.      |.|..|....|..|:....::...:.:|.:  
  Fly  1986 IYFVIFIVCGSFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQKHYYTAMKKLGRKKPQK-- 2048

Mouse  1102 IPKNPYQY--QVWYVVTSS-YFEYLMFALIMLNTICLGMQHYNQSEQMNHISDILNVAFTIIFTL 1163
            :.|.|..:  .::|.:::| .||..:|.||.||.:.:|::||:|...:..|.::.|..||.:|.|
  Fly  2049 VIKRPINHFLAMFYDLSNSRRFEIAIFVLIFLNMLTMGIEHYDQPHAVFFILEVSNAFFTTVFGL 2113

Mouse  1164 EMVLKLIAFKPRGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGGGCGNVDPDESA 1228
            |.::|::..:.. ||..||||||||:|:.||..:::.:|...|..|..|               .
  Fly  2114 EAIVKIVGLRYH-YFTVPWNVFDFLLVLASIFGILMEDIMIDLPISPTL---------------L 2162

Mouse  1229 RISSAFFRLFRVMRLVKLLNRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIA 1293
            |:    .|:||:.|:::|:..|:|:|.||:..:.|..||..:..|:.::.||||::||.:||.:.
  Fly  2163 RV----VRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNIGALLGLITFIYAILGMSLFGNVK 2223

Mouse  1294 MVDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEILLACSYGKL-CDPESDYAPGEEHT---CG- 1353
            :...  ::...|||||.:::.||||..|...|.::|.:...... |||   :..|  ||   || 
  Fly  2224 LQGA--LDDMVNFQTFGRSMQLLFRLMTSAGWNDVLESLMIQPPDCDP---FIHG--HTNGNCGH 2281

Mouse  1354 TNFAYYYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSI-LGPHHLDEFKAIWAEYDPEAKGRI 1417
            ...|..||.||.::...::||:::|:|::||:...::..| :....|:.|...|::|||.|...|
  Fly  2282 PLLAITYFTSFIIISYMIVINMYIAIILENFNQAHQEEEIGIVEDDLEMFYIRWSKYDPHATQFI 2346

Mouse  1418 KHLDVVTLLRRIQPPLGFGKFCPHRVACKRLVGMNMPLNSDGTVTFNATLFALVRTAL-KIKTEG 1481
            ....:...:..:.||||..|  |:.||   ||..|:|::....:.....|.|||:..| .::...
  Fly  2347 HFSQLSDFIASLDPPLGISK--PNNVA---LVSFNLPISKGNKIHCLDILHALVKHVLGHVEETD 2406

Mouse  1482 NFEQANEELRAIIKK---------------IWKRTSMKLLDQVIPPIGDDEVTVGKFYATFLIQE 1531
            ||:|..|::....||               ||||...                     |...||.
  Fly  2407 NFKQLQEQMDVKFKKQFPTRKELEIVSSTRIWKRQEK---------------------AAKTIQT 2450

Mouse  1532 HFRKFMKRQEEYY---------------GYRPKKDTV---QIQAGLR------------------ 1560
            .::::::|:.|..               |::.|...:   .:|...|                  
  Fly  2451 GWKEYLRRKREKERSNSGDSATQTSSPGGWQSKLSALNFFHLQVSRRGTACSSRASSRKSSRASD 2515

Mouse  1561 --TIEEEAAPEIH---RAISGDLTAEEELERAMVEAAMEEGIFRRTGGLFGQVDNFLERTNSLPP 1620
              .:.|.|.|.::   ..:||    .:|:.:.:.:...|.|   :.|.:|.:.           |
  Fly  2516 ASDLSELAGPWLNLPLMLVSG----ADEVVKDIKQQNDELG---KRGSIFVEA-----------P 2562

Mouse  1621 VMANQRPLQFAEIEMEELESPVFLEDFPQNPGTH-PLARANTNNANANVA--YGNSSHRNNPVFS 1682
            ..:.:|  .|....:...::   ::|...:|..| ..|..||.|..:|.|  .|.:|        
  Fly  2563 RASRRR--SFYNFFLRHQDA---VDDSLTSPSVHRKTAMNNTTNTTSNSASTSGTAS-------- 2614

Mouse  1683 SICYEREFLGEADMPVTREGPLSQPCRASGPH---------SRSHVDKL--KRPMTQRGM----- 1731
                     ..|..|.|..||.:.....|..|         ||......  |:|..:||:     
  Fly  2615 ---------STATAPATGCGPAATSASDSDRHQAVGGGSAPSRKRASSFIRKKPPLERGLSAQSA 2670

Mouse  1732 ---------PEGQVP------PSPCQVTGAKAEHPVQKEGKGPTSRFLETPNSRNFEEHVPRNSA 1781
                     .|...|      |||.|.|     ||.....:...:..:.....|..||:...:. 
  Fly  2671 LRVNKNAFVSEASAPEVIVTRPSPEQQT-----HPHSLSLRPDNATLVHVLVHRESEEYKEEDE- 2729

Mouse  1782 HRCTAPATAMLIQEALVRG-------GLDSLAAD--ANFVMATG--QALADACQMEPEEVEVAAT 1835
               ::|:         |.|       |||.|:..  ....:.||  ::..|.|.|...::.|.: 
  Fly  2730 ---SSPS---------VSGNGNGFGVGLDMLSKQPPPQIRITTGSVESSMDTCAMPTVQIMVDS- 2781

Mouse  1836 ELLKQESPEG 1845
               .::.|.|
  Fly  2782 ---PKDPPRG 2788

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cacna1sNP_001074492.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..23
I. /evidence=ECO:0000305 38..337 100/373 (27%)
Ion_trans 68..345 CDD:278921 92/351 (26%)
Selectivity filter of repeat I. /evidence=ECO:0000250|UniProtKB:P07293 290..293 0/2 (0%)
Binding to the beta subunit. /evidence=ECO:0000269|PubMed:28351836 357..374 6/69 (9%)
II. /evidence=ECO:0000305 418..664 82/264 (31%)
Ion_trans 449..672 CDD:278921 75/228 (33%)
Selectivity filter of repeat II. /evidence=ECO:0000250|UniProtKB:P07293 612..615 1/2 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 675..712 17/251 (7%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 731..757 12/165 (7%)
III. /evidence=ECO:0000305 768..1068 100/510 (20%)
Ion_trans 816..1075 CDD:278921 86/275 (31%)
Dihydropyridine binding. /evidence=ECO:0000250|UniProtKB:P07293 988..1077 30/94 (32%)
Selectivity filter of repeat III. /evidence=ECO:0000250|UniProtKB:P07293 1012..1015 2/2 (100%)
IV. /evidence=ECO:0000305 1105..1384 91/286 (32%)
Ion_trans 1135..1392 CDD:278921 83/261 (32%)
Selectivity filter of repeat IV. /evidence=ECO:0000250|UniProtKB:P07293 1321..1324 1/2 (50%)
Dihydropyridine binding. /evidence=ECO:0000250|UniProtKB:P07293 1337..1403 21/71 (30%)
Phenylalkylamine binding. /evidence=ECO:0000250 1349..1392 15/46 (33%)
Phenylalkylamine binding. /evidence=ECO:0000250|UniProtKB:P07293 1349..1391 15/45 (33%)
GPHH 1400..1463 CDD:293510 19/62 (31%)
Ca_chan_IQ 1465..1536 CDD:285917 18/86 (21%)
Interaction with calmodulin. /evidence=ECO:0000250|UniProtKB:Q13698 1522..1542 4/19 (21%)
CAC1F_C <1679..1840 CDD:293490 38/202 (19%)
NaCP60ENP_001261172.1 Ion_trans 152..371 CDD:278921 76/239 (32%)
Ion_trans 705..902 CDD:278921 67/208 (32%)
Ion_trans 1768..2019 CDD:278921 84/270 (31%)
Na_channel_gate 2009..2063 CDD:240441 9/55 (16%)
Ion_trans 2085..2320 CDD:278921 83/261 (32%)
GPHH 2331..2386 CDD:293510 19/59 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R175
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.840

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