Protein Alignment Cacna1d and NaCP60E

DIOPT Version :10

• Sequence 1: XP_006518538.1
• Gene: Cacna1d / 12289
• MGIID: 88293
• Length: 2207
• Species: Mus musculus
• Sequence 2: NP_001261172.1
• Gene: NaCP60E / 37981
• FlyBaseID: FBgn0085434
• Length: 2896
• Species: Drosophila melanogaster
• Alignment Length: 3033
• Identity: 587/3033 - (19%)
• Similarity: 974/3033 - (32%)
• Gaps: 1267/3033 - (41%)

Mouse    80 LSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVALA 144
            :|:|.|:.|. .:..|..|       ||.....:|.||.|:.|...:.||..::..|..||:.||
  Fly    88 VSKRFRKNYI-HRFTGTKS-------LFLFYPWSPARRVCVYIATNQFFDYCVMATILFNCIFLA 144

Mouse   145 IYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGL 209
            :            ...:|:.||.||.|:::|..:||||.|.||:...|:||.||.||||::..|.
  Fly   145 M------------TETVEEAEYIFLAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSGY 197

Mouse   210 FSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHI 274
            .::.:|.       ||          :..||.|||||.|:.||.:|.|:.::|:::.:...|..:
  Fly   198 ATIGMEV-------GN----------LAGLRTFRVLRALKTVSIMPGLKTIINALLHSFRQLAEV 245

Mouse   275 ALLVLFVIIIYAIIGLELFIGKMHKTC------------------FFADSD-IVAEEDPAP--CA 318
            ..|.:|.::::|:..|::::|::...|                  :..|:| .:.:||..|  |.
  Fly   246 MTLTIFCLMVFALFALQVYMGELRNKCVRQVPTDWTNVSHTDWQIWVNDTDNWLYDEDELPVLCG 310

Mouse   319 FSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAIGWEWPW 383
            .....|.|..... |......||.|.||||||.::|||.||.||::.|.:|...|....|   |.
  Fly   311 NLTGARHCPFEYV-CLCVGENPNHGYTNFDNFMWSMLTTFQLITLDYWENVYNMVLATCG---PM 371

Mouse   384 --VYFVSLIILGSFFVLNLVL-------------------------------------------- 402
              .:|..::..|||:::||:|
  Fly   372 SVSFFTVVVFFGSFYLINLMLAVVALSYEEEAEITNEERKKDLLDHRDDSTFSFDPSVLNVKKLN 436

Mouse   403 -----------GVLSGEFSKEREKAK----------------ARGD------------------- 421
                       |||...:||::.:.|                :.||
  Fly   437 KNNKKKIDSRKGVLLASYSKKKTRRKKTKGGKEGGTNGNGNGSNGDDNKSHSATPSPGPSPRHSA 501

Mouse   422 --------FQKLREKQQLEED------------------LKGYLDWITQAEDI-DPENEEEGGEE 459
                    .|..::.||:|:.                  .||.:.:......: :|........:
  Fly   502 TERPSALTMQAQKQYQQMEQQHKLAKSGSGGSNNPMAPTPKGRISFQDSGMGVKNPNMLYPSDYK 566

Mouse   460 GK--RNTSMPTSETESVNTEN------VSGEGETQGCCGTLWCWWKRRGAAKT-----GPSGCR- 510
            |:  .|:..|:|.:..||.|:      |..:.|.|.....:       |...|     .|...|
  Fly   567 GQLIANSGQPSSNSSGVNRESSQDDSGVVDDHEEQDTTNDM-------GHVSTVELALSPREVRL 624

Mouse   511 -RWGQAISKSKLSRRWRRWNRFNR----------RRCRAAVKSVTFY--WL-------------- 548
             :....|::.|....:.....|:.          |.|...|...|.|  ||
  Fly   625 IKCNGNIARIKNHNVYALHQEFSSEVVVIDDLPDRNCDRCVHWCTDYESWLQFQNCLYKVVRDPL 689

Mouse   549 ----VIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFNR 609
                :.:.:.|||..::.||:...:......|:.|||..::||.|.:||:.:|. :.:|:..:|.
  Fly   690 FELAITLCIVLNTAFLAMEHHGMSESFRNALDVGNKVFTSIFTFECIVKLMALS-KDFFLCGWNI 753

Mouse   610 FDCFVVCGGITETILVELELMSPLGVSVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLL 674
            ||..:|...:.:.|   .||:.  |:||.|.:||||:.|:.:.||::..|::.:::::.::.:|.
  Fly   754 FDLLIVTASLLDII---FELVD--GLSVLRGLRLLRVLKLAQSWTTMKVLLSIIISTIGALGNLT 813

Mouse   675 LLLFLFIIIFSLLGMQLFGGKF---NFDETQTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIM 736
            |:|.:.|.||:::|||||...:   .||.....|..|::|..:.:.:|:||.|| |...::|.:.
  Fly   814 LILVIVIYIFAVIGMQLFSKDYTPEKFDPDPVPRWNFNDFFHSFMMIFRILCGE-WIEPLWDCMR 877

Mouse   737 AYGGPSSSGMIVCI-YFIILFICGNYILLNVFLAIAVDNLADAESLNTAQKEEAEEKE------- 793
            |   ....|...|. .|:...:.||:::||:|||:.: |..::|.|.:.::|..||.:
  Fly   878 A---EEEQGASTCFAIFLPTLVMGNFMVLNLFLALLL-NSFNSEELKSKKEEVGEESKLARSIER 938

Mouse   794 ------RKKIARKESLENK-----------------------------KNNKPEV---------- 813
                  :|:..||:..|.|                             :.:||.|
  Fly   939 VRDLIRKKRQERKDRKERKFAEKFQQIVLDAQQAHAQTLSHQAAVGLERGDKPGVLAETKFHRLS 1003

Mouse   814 ---------------NQIANSDNKVTIDD------------------------------------ 827
                           .||...|...||.|
  Fly  1004 YQESMNRPVSGSDFGFQIPLHDGLHTIVDGLEYDDTGDLPEQIQLQAHPLPPTSDSMPPTYESAM 1068

Mouse   828 --------------------------------------------------YQEDAE--------D 834
                                                              |.|..|        |
  Fly  1069 MATTGGSFSSVNGNGTCQNLTPFVQAERRLQHQISSGVSTQQYDSREEATYTESIELLGQYNSTD 1133

Mouse   835 KDPYP------------------------------------------------------------ 839
            .|||.
  Fly  1134 TDPYANDQRSGCGSFNRGDSLQDNSSRRYGSEEHDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQ 1198

Mouse   840 --------------------------------------------PCDVP-----VGEEEE----- 850
                                                        .||..     :.||||
  Fly  1199 SQRSLLKSEEAEMRRHSSGQSLNSMSIEQDELLSQQGNLREELLNCDQKELFQFLQEEEELQKGT 1263

Mouse   851 -----------------------------------------EEEE-------------------- 854
                                                     |.||
  Fly  1264 KLRRISNVMRSRRPSSQMGQPENETMVEHSEFDNIIQSFEKELEEIKRSTTSLERKLSNLSEPSP 1328

Mouse   855 -------------------------DEPEVPAGP------------------------------- 863
                                     ||..:|..|
  Fly  1329 AADEATKAIMEHIAIITGASERSAADEVVLPLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRS 1393

Mouse   864 --RPRRISE-------------------------------------------------------- 870
              :.|:|.|
  Fly  1394 LEKQRKIDEDFSISNEIRKICDQIHAPFVAMEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFDR 1458

Mouse   871 ---LNMKEKIAPIPEGS------------------------------------------------ 884
               |::.|::..:||..
  Fly  1459 FKRLSLIERVEEVPEEEKPISTLRIESEKMPRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQKLG 1523

Mouse   885 -----------------------------------------------AFFILSKTNPIRVGCHKL 902
                                                           |..|.:...|.....|..
  Fly  1524 MATPPAVPATPPTSLKSSIEPPTLAQISSLKTTPPLAALTEHQQHFHATSIQAAPTPAHTHAHSQ 1588

Mouse   903 INHH------------------------------------------------------------- 906
            .:.|
  Fly  1589 AHAHSMAGQRRRMEHPQSTLDKAASFQSARTESHSSGAADASSALALAMAQKTEQSQSTAPDATQ 1653

Mouse   907 ---IFTNL--------------------------------------------------------- 911
               .||.|
  Fly  1654 KPSAFTRLTEKPWHCLVSYVDDLTVGGRRNSQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDHF 1718

Mouse   912 --------------------------------------ILVFIMLSSAALAAED-PIRSHSFRNT 937
                                                  :||.|..||..|..|| .:..:.....
  Fly  1719 YFRCPWFMSCMDTQSAKHWTRVRTAVLTVVDTPAFEWFVLVLIFASSITLCFEDINLDKNKTLKR 1783

Mouse   938 ILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSA-ISVVK 1001
            :|.:.:::|..||.||::||....|.    ..:..:::.:||.::|.||:.|..|:.:. :.|::
  Fly  1784 VLYWINFSFCLIFVVEMILKWLALGF----SKYFTSFWTILDFIIVFVSVFSLLIEENENLKVLR 1844

Mouse  1002 ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTD 1066
            .||.||.|||||||:|.:|::.||..:..||.:|.|:::|..:...:|:.:|||.|.|||::|.:
  Fly  1845 SLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVN 1909

Mouse  1067 EAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAI 1131
            |...       |..:.:..|....:.:...|.||...||:|....:||..|:|||||..::..|:
  Fly  1910 EMGE-------LLPITEVNDKWDCIEQNYTWINSKITFDHVGMGYLALLQVATFEGWMEVMADAV 1967

Mouse  1132 DSNGENVGPVYNYRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQ------EQGEKEYKNCELDK 1190
            |:.|.::.|.....:...|:|:|:|:..:||.:|:|:|.:|..|.      |.|..|....|..|
  Fly  1968 DARGVDLQPQREANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQK 2032

Mouse  1191 NQRQCVEYALKARP---LRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKM 1252
            :....::...:.:|   ::|  |.|.:...|:.:.||..||..:||||.||.|.:.::||:|...
  Fly  2033 HYYTAMKKLGRKKPQKVIKR--PINHFLAMFYDLSNSRRFEIAIFVLIFLNMLTMGIEHYDQPHA 2095

Mouse  1253 FNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADHYFTDAW 1317
            ....:::.|..||.||.:|.::|::..:   |                          ||||..|
  Fly  2096 VFFILEVSNAFFTTVFGLEAIVKIVGLR---Y--------------------------HYFTVPW 2131

Mouse  1318 NTFDALIVVGSVVDIAITEVNPSESETIPLPTATPGNSEESNRISITFF---RLFRVMRLVKLLS 1379
            |.||.|:|:.|:..|.:.::      .|.||            ||.|..   |:||:.|:::|:.
  Fly  2132 NVFDFLLVLASIFGILMEDI------MIDLP------------ISPTLLRVVRVFRIGRILRLIK 2178

Mouse  1380 RGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAV 1444
            ..:|||.||:..:.|..||..:..|:.::.||||::||.:||.|.::  ..::...|||||.:::
  Fly  2179 AAKGIRKLLFALVVSLPALFNIGALLGLITFIYAILGMSLFGNVKLQ--GALDDMVNFQTFGRSM 2241

Mouse  1445 LLLFRCATGEAWQEIMLACLPGKLCDPDSD-----YNPGEEYTCGSN-FAIVYFISFYMLCAFLI 1503
            .||||..|...|.:::.:.:   :..||.|     :..|   .||.. .||.||.||.::...::
  Fly  2242 QLLFRLMTSAGWNDVLESLM---IQPPDCDPFIHGHTNG---NCGHPLLAITYFTSFIIISYMIV 2300

Mouse  1504 INLFVAVIMDNFDYLTRDWSI-LGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFG 1567
            ||:::|:|::||:...::..| :....|:.|...||:|||.|...|....:...:..:.||||..
  Fly  2301 INMYIAIILENFNQAHQEEEIGIVEDDLEMFYIRWSKYDPHATQFIHFSQLSDFIASLDPPLGIS 2365

Mouse  1568 KLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTAL-KIKTEGNLEQANEELRAVIKK---- 1627
            |  |:.||   ||:.|:|::....:.....|.|||:..| .::...|.:|..|::....||
  Fly  2366 K--PNNVA---LVSFNLPISKGNKIHCLDILHALVKHVLGHVEETDNFKQLQEQMDVKFKKQFPT 2425

Mouse  1628 -----------IWKKTSMKLLDQVVPPAGDDEVTVGKFYATFLIQ----DYFRKFKKRKEQGLVG 1677
                       |||:...                     |...||    :|.|: |:.||:...|
  Fly  2426 RKELEIVSSTRIWKRQEK---------------------AAKTIQTGWKEYLRR-KREKERSNSG 2468

Mouse  1678 KYPAKNTTI-ALQAGLRTLHDIGPEI-RRAISC----------------DLQ------------- 1711
            ....:.::. ..|:.|..|:....:: ||..:|                ||.
  Fly  2469 DSATQTSSPGGWQSKLSALNFFHLQVSRRGTACSSRASSRKSSRASDASDLSELAGPWLNLPLML 2533

Mouse  1712 ----DDEPEDSKPEEEDVFKRNGALLGNHVNHVNSDRR---------------DSL--------- 1748
                |:..:|.|.:.:::.|| |::.   |....:.||               |||
  Fly  2534 VSGADEVVKDIKQQNDELGKR-GSIF---VEAPRASRRRSFYNFFLRHQDAVDDSLTSPSVHRKT 2594

Mouse  1749 QQTNTTHRPLHVQRPSMPPASDTEKPL--FPPAGNSGCHNHHNHNSIGKQAPTSTNANLNNANMS 1811
            ...|||:...:....|...:|....|.  ..||..|...:..:....|..||:...|       |
  Fly  2595 AMNNTTNTTSNSASTSGTASSTATAPATGCGPAATSASDSDRHQAVGGGSAPSRKRA-------S 2652

Mouse  1812 KAAHGKPPSIGNLEHVSENGHYSCKHDRELQRRSSIKRTRYYETYIRSESGDEQFPTICREDPEI 1876
            .....|||.                 :|.|..:|:::..:  ..::...|..|...|  |..||.
  Fly  2653 SFIRKKPPL-----------------ERGLSAQSALRVNK--NAFVSEASAPEVIVT--RPSPEQ 2696

Mouse  1877 HGYFRDPRCLG---------------EQEYFSSEECCEDDSSPTWSRQNYNYYNRYPGSSMDF-- 1924
            ..:   |..|.               |.|.:..    ||:|||:.|.....:     |..:|.
  Fly  2697 QTH---PHSLSLRPDNATLVHVLVHRESEEYKE----EDESSPSVSGNGNGF-----GVGLDMLS 2749

Mouse  1925 ERPRGYHHPQGFLEDDDSPTGYDSRRSPRRRLLPPTPPSHRRSSFNFECLRRQSSQDDVLPSPAL 1989
            ::|    .||..:......:..|:...|..:::..:|....|..|:      .:..|||
  Fly  2750 KQP----PPQIRITTGSVESSMDTCAMPTVQIMVDSPKDPPRGDFS------SAPIDDV------ 2798

Mouse  1990 PHRAALPLHLMQQQIMAVAGLDSSKAQKYSPSHSTRSWA-----------------TPPATPPYR 2037
                ..|:.      :.|.|..|.....|:|..:|....                  ||...|.|
  Fly  2799 ----GAPID------VNVQGDTSQVFYDYNPEKATDDQGNGQDETAQFESLPDRQRXPPVNTPLR 2853

Mouse  2038 D-----------WSPCYTPLIQVDRSESMDQVNGSLPSLHRSS 2069
            |           .|...:.:.....|.|....:.:.||..|:|
  Fly  2854 DSEKRSSRGSRSSSSSTSSIRSCSSSSSSSAASAAAPSARRTS 2896

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cacna1d	XP_006518538.1	Ion_trans	125..417	CDD:459842	96/369 (26%)
		Ion_trans	545..780	CDD:459842	73/258 (28%)
		Ion_trans	905..1182	CDD:459842	92/443 (21%)
		Ion_trans	1224..1523	CDD:459842	91/307 (30%)
		GPHH	1532..1585	CDD:465306	19/52 (37%)
		Ca_chan_IQ	1595..1669	CDD:462591	18/93 (19%)
		CAC1F_C	1690..2206	CDD:465298	87/485 (18%)
NaCP60E	NP_001261172.1	Ion_trans	125..371	CDD:459842	83/278 (30%)
		Ion_trans	687..902	CDD:459842	64/224 (29%)
		Ion_trans	1751..2019	CDD:459842	86/278 (31%)
		Na_channel_gate	2009..2063	CDD:240441	11/55 (20%)
		Ion_trans	2067..2320	CDD:459842	91/307 (30%)
		GPHH	2332..2378	CDD:465306	18/50 (36%)