DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Cacna1b and NaCP60E

DIOPT Version :9

Sequence 1:XP_006497689.1 Gene:Cacna1b / 12287 MGIID:88296 Length:2351 Species:Mus musculus
Sequence 2:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster


Alignment Length:2877 Identity:635/2877 - (22%)
Similarity:1066/2877 - (37%) Gaps:889/2877 - (30%)


- Green bases have known domain annotations that are detailed below.


Mouse    44 LYKQS---IAQRARTMALYNPIPVKQNCFTVNRSLFVFSEDNVVRKYAKRITEWPPFEYMILATI 105
            :|:::   :::|.|...::.        ||..:|||:|...:..|:....|.....|:|.::|||
  Fly    80 IYEETFCVVSKRFRKNYIHR--------FTGTKSLFLFYPWSPARRVCVYIATNQFFDYCVMATI 136

Mouse   106 IANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMD 170
            :.|||.||            |:|.:::.|..|:.|:..|..|||||.||:.:|.:||||.||.:|
  Fly   137 LFNCIFLA------------MTETVEEAEYIFLAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLD 189

Mouse   171 FVVVLTGILATAGTDF-DLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAI 234
            |||:.:| .||.|.:. :|..||..||||.||.||.:|.|:.::.:::.:...|.::..|..|.:
  Fly   190 FVVITSG-YATIGMEVGNLAGLRTFRVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCL 253

Mouse   235 LMFAIIGLEFYMGKFHKAC------------------FPNSTDT--EPVGDFP--CGKDPPARQC 277
            ::||:..|:.|||:....|                  :.|.||.  ....:.|  ||....||.|
  Fly   254 MVFALFALQVYMGELRNKCVRQVPTDWTNVSHTDWQIWVNDTDNWLYDEDELPVLCGNLTGARHC 318

Mouse   278 DGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIII 342
            ..:..|......||.|.|||||.::::||.||.||::.|.:: ||...|.....:..:|..::..
  Fly   319 PFEYVCLCVGENPNHGYTNFDNFMWSMLTTFQLITLDYWENV-YNMVLATCGPMSVSFFTVVVFF 382

Mouse   343 GSFFMLNLVLGVLSGEFAKERE--RVENRRAFLKLRRQQQIE--------RELN-GYLEWIFKAE 396
            |||:::||:|.|::..:.:|.|  ..|.::..|..|......        ::|| ...:.|...:
  Fly   383 GSFYLINLMLAVVALSYEEEAEITNEERKKDLLDHRDDSTFSFDPSVLNVKKLNKNNKKKIDSRK 447

Mouse   397 EVMLAE----------------------------EDKNAEEKSPLDAVLKR-AATKK-------- 424
            .|:||.                            :|..:...:|......| :||::        
  Fly   448 GVLLASYSKKKTRRKKTKGGKEGGTNGNGNGSNGDDNKSHSATPSPGPSPRHSATERPSALTMQA 512

Mouse   425 --------------------SRNDLIHAEEGEDRFVD--------------------LCAVGSPF 449
                                |.|.:....:|...|.|                    :...|.| 
  Fly   513 QKQYQQMEQQHKLAKSGSGGSNNPMAPTPKGRISFQDSGMGVKNPNMLYPSDYKGQLIANSGQP- 576

Mouse   450 ARASLKSGKTESSS--------------------------------------------------- 463
              :|..||....||                                                   
  Fly   577 --SSNSSGVNRESSQDDSGVVDDHEEQDTTNDMGHVSTVELALSPREVRLIKCNGNIARIKNHNV 639

Mouse   464 YFRRKE-----------------------------KMFRFFIRRMVKAQSFYWVVLCVVALNTLC 499
            |...:|                             ..|:..:.::|:...|...:...:.|||..
  Fly   640 YALHQEFSSEVVVIDDLPDRNCDRCVHWCTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAF 704

Mouse   500 VAMVHYNQPQRLTTALYFAEFVFLGLFLTEMSLKMYGLGPRSYFRSSFNCFDFGVIVGSIFEVVW 564
            :||.|:...:....||.....||..:|..|..:|:..|. :.:|...:|.||..::..|:.::::
  Fly   705 LAMEHHGMSESFRNALDVGNKVFTSIFTFECIVKLMALS-KDFFLCGWNIFDLLIVTASLLDIIF 768

Mouse   565 AAIKPGTSFGISVLRALRLLRIFKVTKYWNSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGM 629
            ..:.     |:||||.|||||:.|:.:.|.:::.|:..:::::.::.:|..:|.:.|.:||::||
  Fly   769 ELVD-----GLSVLRGLRLLRVLKLAQSWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGM 828

Mouse   630 QLFGGQFNFQ----DETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVSKGMFSSFYF 690
            |||...:..:    |..|..||:.|..:.:.:|:||.|| |...::..:.::  ..:|..:.|..
  Fly   829 QLFSKDYTPEKFDPDPVPRWNFNDFFHSFMMIFRILCGE-WIEPLWDCMRAE--EEQGASTCFAI 890

Mouse   691 IVLTL-FGNYTLLNVFLAIAVDNLANAQELTKDEEEMEEAANQKLALQKAKE------------- 741
            .:.|| .||:.:||:|||:.: |..|::||...:||:.|.:....::::.::             
  Fly   891 FLPTLVMGNFMVLNLFLALLL-NSFNSEELKSKKEEVGEESKLARSIERVRDLIRKKRQERKDRK 954

Mouse   742 -----------VAEVSPMSAANISIAAFVKQTRG----------------------TVSRS---- 769
                       |.:.....|..:|..|.|...||                      .||.|    
  Fly   955 ERKFAEKFQQIVLDAQQAHAQTLSHQAAVGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGF 1019

Mouse   770 ------------------------------------------------------SSVSSVN---- 776
                                                                  .|.||||    
  Fly  1020 QIPLHDGLHTIVDGLEYDDTGDLPEQIQLQAHPLPPTSDSMPPTYESAMMATTGGSFSSVNGNGT 1084

Mouse   777 ----SPRQQNSAKARSVWEQRASQLRLQNLRASCEALYSE------------MDP---EER---- 818
                :|..|   ..|.:..|.:|.:..|...:..||.|:|            .||   ::|    
  Fly  1085 CQNLTPFVQ---AERRLQHQISSGVSTQQYDSREEATYTESIELLGQYNSTDTDPYANDQRSGCG 1146

Mouse   819 -------------LRYASTRHVR-------------PDMKTHMDR-------------------- 837
                         .||.|..|..             |..:..:||                    
  Fly  1147 SFNRGDSLQDNSSRRYGSEEHDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEM 1211

Mouse   838 -----------------PLVVEPG--RDGL---------------------------------RG 850
                             .|:.:.|  |:.|                                 |.
  Fly  1212 RRHSSGQSLNSMSIEQDELLSQQGNLREELLNCDQKELFQFLQEEEELQKGTKLRRISNVMRSRR 1276

Mouse   851 PVGSKSKPEGTEATESADLP-------------RRHHRHRDRDKTSATAPAGGEQDRTESTE--- 899
            |.....:||.....|.::..             :|.....:|..::.:.|:....:.|::..   
  Fly  1277 PSSQMGQPENETMVEHSEFDNIIQSFEKELEEIKRSTTSLERKLSNLSEPSPAADEATKAIMEHI 1341

Mouse   900 ---TGAREERAR------------------PRRSHSKETPGADTQVRCERSRRHHRRGSPEE-AT 942
               |||.|..|.                  ||||.|.........|:.:|.....:|...|: :.
  Fly  1342 AIITGASERSAADEVVLPLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDFSI 1406

Mouse   943 EREPRRHRAHRHAQDSSKEGTAPVLVPKGERRARHRGPRTGPREAENNEEPTRRHRARHKVPP-- 1005
            ..|.|:.....||...:.|..|..              .|...:|:.|:.|.    .|.||.|  
  Fly  1407 SNEIRKICDQIHAPFVAMEAMAVA--------------ATSASQAQPNQSPF----LRRKVDPFT 1453

Mouse  1006 -------TLQPPER--EAAEKE----SNAVEGDKETRN--HQPKEPHCDLEAIAVT--------- 1046
                   .|...||  |..|:|    :..:|.:|..|.  |.|.:...|..::..|         
  Fly  1454 VQFDRFKRLSLIERVEEVPEEEKPISTLRIESEKMPRKFLHGPDQLRLDSLSLKSTNSYENLLIQ 1518

Mouse  1047 ----GVG---PLHMLPSTCLQKVDEQPEDA---------------DNQR--NVTRMGSQPSDPST 1087
                |:.   .:...|.|.|:...|.|..|               ::|:  :.|.:.:.|:...|
  Fly  1519 KQKLGMATPPAVPATPPTSLKSSIEPPTLAQISSLKTTPPLAALTEHQQHFHATSIQAAPTPAHT 1583

Mouse  1088 TVHVPVTLTGPPGETPVV--PSGNMN---------LEGQAEGKKEAEA----------------- 1124
            ..|.........|:...:  |...::         .|..:.|..:|.:                 
  Fly  1584 HAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQSARTESHSSGAADASSALALAMAQKTEQSQSTA 1648

Mouse  1125 -------------------------DDVLRRG----------PRPIVPYSS-------------- 1140
                                     ||:...|          |.....|.:              
  Fly  1649 PDATQKPSAFTRLTEKPWHCLVSYVDDLTVGGRRNSQGAYNDPMTFPSYGATKAAKVPDDCFPQK 1713

Mouse  1141 ------------MFCLSPTNL-----LRRFCHYIVTMRYFEMVILVVIALSSIALAAEDPVRTDS 1188
                        |.|:...:.     :|.....:|....||..:||:|..|||.|..|| :..| 
  Fly  1714 CYDHFYFRCPWFMSCMDTQSAKHWTRVRTAVLTVVDTPAFEWFVLVLIFASSITLCFED-INLD- 1776

Mouse  1189 FRNNALK----YMDYIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSS 1249
             :|..||    ::::.|..:|..||::|.:.||.    ..||...|.|||||:|    ....||.
  Fly  1777 -KNKTLKRVLYWINFSFCLIFVVEMILKWLALGF----SKYFTSFWTILDFIIV----FVSVFSL 1832

Mouse  1250 FMGGSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVI 1314
            .:  .:.:::..::|||.||.||||:.|.|...::.|.:.::.::.::.|:|:|.::|..||:::
  Fly  1833 LI--EENENLKVLRSLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIM 1895

Mouse  1315 AVQLFKGKFFYCTDESKEL--------ERDCRGQYLDYEKEEVEAQPRQWKKYDFHYDNVLWALL 1371
            .||.|.||||.|.:|..||        :.||           :| |...|......:|:|....|
  Fly  1896 GVQFFGGKFFKCVNEMGELLPITEVNDKWDC-----------IE-QNYTWINSKITFDHVGMGYL 1948

Mouse  1372 TLFTVSTGEGWPMVLKHSVDATYEEQGPSPGFRMELSIFYVVYFVVF----PFFFVNIFVALIII 1432
            .|..|:|.|||..|:..:|||...:..|    :.|.:::..:|||:|    .||.:|:|:.:||.
  Fly  1949 ALLQVATFEGWMEVMADAVDARGVDLQP----QREANLYAYIYFVIFIVCGSFFTLNLFIGVIID 2009

Mouse  1433 TF---QEQGDKVMSECSLEKNERACIDFAISAKPLTRYMPQNK-----QSFQYKTWTFVVSPPFE 1489
            .|   :::.:..:.|..|.::::   .:..:.|.|.|..||..     ..|....:....|..||
  Fly  2010 NFNMLKKKYEGGVLEMFLTESQK---HYYTAMKKLGRKKPQKVIKRPINHFLAMFYDLSNSRRFE 2071

Mouse  1490 YFIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECILKIIAFGVLNYFRDAWNVFD 1554
            ..|..:|.||.:.:.::.||.|:....:|:..|..||::|.:|.|:||:... .:||...|||||
  Fly  2072 IAIFVLIFLNMLTMGIEHYDQPHAVFFILEVSNAFFTTVFGLEAIVKIVGLR-YHYFTVPWNVFD 2135

Mouse  1555 FVTVLGSITDILVTEIAETNNFINLSF-------LRLFRAARLIKLLRQGYTIRILLWTFVQSFK 1612
            |:.||.||..||:.:|     .|:|..       :|:||..|:::|::....||.||:..|.|..
  Fly  2136 FLLVLASIFGILMEDI-----MIDLPISPTLLRVVRVFRIGRILRLIKAAKGIRKLLFALVVSLP 2195

Mouse  1613 ALPYVCLLIAMLFFIYAIIGMQVFGNI----ALDDDTSINRHNNFRTFLQALMLLFRSATGEAWH 1673
            ||..:..|:.::.|||||:||.:|||:    ||||..      ||:||.:::.||||..|...|:
  Fly  2196 ALFNIGALLGLITFIYAILGMSLFGNVKLQGALDDMV------NFQTFGRSMQLLFRLMTSAGWN 2254

Mouse  1674 EIMLSCLGNRA-CDP----HANASECGSD-FAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRD 1732
            :::.|.:.... |||    |.|.: ||.. .|..||.|||.:...:::|:::|:|::||....::
  Fly  2255 DVLESLMIQPPDCDPFIHGHTNGN-CGHPLLAITYFTSFIIISYMIVINMYIAIILENFNQAHQE 2318

Mouse  1733 SSI-LGPHHLDEFIRVWAEYDPAACGRISYNDMFEMLKHMSPPLGLGKKCPARVAYKRLVRMNMP 1796
            ..| :....|:.|...|::|||.|...|.::.:.:.:..:.||||:.|  |..||   ||..|:|
  Fly  2319 EEIGIVEDDLEMFYIRWSKYDPHATQFIHFSQLSDFIASLDPPLGISK--PNNVA---LVSFNLP 2378

Mouse  1797 ISNEDMTVHFTSTLMALIRTALEIKLAPAGTK--QHQCDAELRKEISSVWANLPQKTLDLLVPPH 1859
            ||..: .:|....|.||::..|.........|  |.|.|.:.:|:..:      :|.|:::....
  Fly  2379 ISKGN-KIHCLDILHALVKHVLGHVEETDNFKQLQEQMDVKFKKQFPT------RKELEIVSSTR 2436

Mouse  1860 --KPDEMTVGKVYAALMIFDFYKQNKTTRDQTH--------QAPGG-LSQMGPVSLFHPLKATLE 1913
              |..|.....:...   :..|.:.|..:::::        .:||| .|::..::.|| |:.:..
  Fly  2437 IWKRQEKAAKTIQTG---WKEYLRRKREKERSNSGDSATQTSSPGGWQSKLSALNFFH-LQVSRR 2497

Mouse  1914 QTQPAVLRGARVFLRQKSATSLSN-------------GGA--------IQTQESGIKESLSWGTQ 1957
            .|..:....:|...|...|:.||.             .||        .|..|.|.:.|:.....
  Fly  2498 GTACSSRASSRKSSRASDASDLSELAGPWLNLPLMLVSGADEVVKDIKQQNDELGKRGSIFVEAP 2562

Mouse  1958 RT-------------QDA---------LYEARAPLERGHSAEIPVGQSGTLAVDVQMQNMTLRGP 2000
            |.             |||         ::...|.....::.......||| |........|..||
  Fly  2563 RASRRRSFYNFFLRHQDAVDDSLTSPSVHRKTAMNNTTNTTSNSASTSGT-ASSTATAPATGCGP 2626

Mouse  2001 ------DGEPQPGLESQGRAASMPRLAAETQPAPNASPMKRSIST-LAPRPHGTQLCS------T 2052
                  |.:....: ..|.|.|..|.::..:..|   |::|.:|. .|.|.:.....|      .
  Fly  2627 AATSASDSDRHQAV-GGGSAPSRKRASSFIRKKP---PLERGLSAQSALRVNKNAFVSEASAPEV 2687

Mouse  2053 VLDRPPPSQASHHHHHRCHRRRDKKQRSLEKGPSLSVDPEGAPSTAAGPGLPHGEGSTACRRDRK 2117
            ::.||.|.|.:|.|                   |||:.|:.|.....   |.|          |:
  Fly  2688 IVTRPSPEQQTHPH-------------------SLSLRPDNATLVHV---LVH----------RE 2720

Mouse  2118 QERGRSQERRQPSSSSSEKQRFYSCDRFGSREPPQLMPSLSSHPTS------PTAAL---EPAPH 2173
            .|..:.::...||.|.:........|....:.|||:..:..|..:|      ||..:   .|...
  Fly  2721 SEEYKEEDESSPSVSGNGNGFGVGLDMLSKQPPPQIRITTGSVESSMDTCAMPTVQIMVDSPKDP 2785

Mouse  2174 PQG---SGSVN--GSPL 2185
            |:|   |..::  |:|:
  Fly  2786 PRGDFSSAPIDDVGAPI 2802

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cacna1bXP_006497689.1 Ion_trans 94..367 CDD:366146 99/297 (33%)
Ion_trans 482..721 CDD:366146 69/243 (28%)
Granin <936..>1041 CDD:279595 27/122 (22%)
Ion_trans 1161..1395 CDD:366146 80/245 (33%)
Ion_trans 1485..1734 CDD:366146 93/265 (35%)
GPHH 1743..1796 CDD:374878 18/52 (35%)
Ca_chan_IQ 1808..1882 CDD:370105 14/77 (18%)
PHA03307 1959..>2326 CDD:223039 55/276 (20%)
NaCP60ENP_001261172.1 Ion_trans 152..371 CDD:278921 77/220 (35%)
Ion_trans 705..902 CDD:278921 56/205 (27%)
Ion_trans 1768..2019 CDD:278921 85/279 (30%)
Na_channel_gate 2009..2063 CDD:240441 9/56 (16%)
Ion_trans 2085..2320 CDD:278921 86/247 (35%)
GPHH 2331..2386 CDD:293510 21/60 (35%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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