Protein Alignment FRMD6 and frmd6

DIOPT Version :10

• Sequence 1: NP_001253975.1
• Gene: FRMD6 / 122786
• HGNCID: 19839
• Length: 622
• Species: Homo sapiens
• Sequence 2: XP_012824779.1
• Gene: frmd6 / 548781
• XenbaseID: XB-GENE-977939
• Length: 610
• Species: Xenopus tropicalis
• Alignment Length: 622
• Identity: 525/622 - (84%)
• Similarity: 570/622 - (91%)
• Gaps: 12/622 - (1%)

Human     1 MNKLNFHNNRVMQDRRSVCIFLPNDESLNIIINVKILCHQLLVQVCDLLRLKDCHLFGLSVIQNN 65
            |:||||.||||||||||||:|||||::||||||||.||.:||.||||||.|:|||||||||||||
 Frog     1 MSKLNFQNNRVMQDRRSVCVFLPNDDTLNIIINVKALCQELLEQVCDLLHLRDCHLFGLSVIQNN 65

Human    66 EHVYMELSQKLYKYCPKEWKKEASKVRQYEVTWGIDQFGPPMIIHFRVQYYVENGRLISDRAARY 130
            |||||||||||||||||||||||||        ||||||||||||||||||||||||||||.|||
 Frog    66 EHVYMELSQKLYKYCPKEWKKEASK--------GIDQFGPPMIIHFRVQYYVENGRLISDRTARY 122

Human   131 YYYWHLRKQVLHSQCVLREEAYFLLAAFALQADLGNFKRNKHYGKYFEPEAYFPSWVVSKRGKDY 195
            |||.|||||||||||:.||||||||||||||||||||||||||||||||||||||||:.||||||
 Frog   123 YYYCHLRKQVLHSQCMQREEAYFLLAAFALQADLGNFKRNKHYGKYFEPEAYFPSWVIKKRGKDY 187

Human   196 ILKHIPNMHKDQFALTASEAHLKYIKEAVRLDDVAVHYYRLYKDKREIEASLTLGLTMRGIQIFQ 260
            |||||||:|:||||||.|||||.|||||.||||||||||:|||||:|:||||.||||:|||||||
 Frog   188 ILKHIPNIHRDQFALTVSEAHLMYIKEAARLDDVAVHYYKLYKDKKEMEASLMLGLTLRGIQIFQ 252

Human   261 NLDEEKQLLYDFPWTNVGKLVFVGKKFEILPDGLPSARKLIYYTGCPMRSRHLLQLLSNSHRLYM 325
            :.|:||||||||||||||||||||||||||||||||||||||||||.:|||||||||||||||||
 Frog   253 SSDDEKQLLYDFPWTNVGKLVFVGKKFEILPDGLPSARKLIYYTGCSVRSRHLLQLLSNSHRLYM 317

Human   326 NLQPVLRHIRKLEENEEKKQYRESYISDNLDLDMDQLEKRSRASGSSAGSMKHKRLSRHSTASHS 390
            |||||||.:|||||:|||||||||||||.||.||||||||||||||||||:||||||||||||||
 Frog   318 NLQPVLRQVRKLEEHEEKKQYRESYISDTLDQDMDQLEKRSRASGSSAGSVKHKRLSRHSTASHS 382

Human   391 SSHTSGIEADTKPRDTGPEDSYSSSAIHRKLKTCSSMTSHGSSHTSGVESGGKDRLEEDLQDDEI 455
            ||||||||||||.||.|||||:|.:::||||||||||||:.||||||.||.||||||:|.|:|||
 Frog   383 SSHTSGIEADTKHRDIGPEDSFSGTSLHRKLKTCSSMTSNSSSHTSGAESAGKDRLEDDSQEDEI 447

Human   456 EMLVDDPRDLEQMNEESLEVSPDMCIYITEDMLMSRKLNGHSGLIVKEIGSSTSSSSETVVKLRG 520
            |||||||:||:.    .|::|||:|||||||||:|::|||||||:|||:.|||||||||||||||
 Frog   448 EMLVDDPKDLDL----PLDISPDLCIYITEDMLVSQQLNGHSGLVVKEVNSSTSSSSETVVKLRG 508

Human   521 QSTDSLPQTICRKPKTSTDRHSLSLDDIRLYQKDFLRIAGLCQDTAQSYTFGCGHELDEEGLYCN 585
            ||.||:|||.||||||||||||||||||||||||||:||||.|:|||||||||||:|.|.|||||
 Frog   509 QSIDSIPQTACRKPKTSTDRHSLSLDDIRLYQKDFLQIAGLNQETAQSYTFGCGHDLHERGLYCN 573

Human   586 SCLAQQCINIQDAFPVKRTSKYFSLDLTHDEVPEFVV 622
            .|||||||||::....|:.|||||||||||:.|||||
 Frog   574 GCLAQQCINIKEPLSSKKASKYFSLDLTHDDFPEFVV 610

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FRMD6	NP_001253975.1	FERM_F1_FRMD6	15..120	CDD:340718	87/104 (84%)
		FERM_M	118..234	CDD:459788	104/115 (90%)
		FERM_C_FRMD1_FRMD6	227..335	CDD:270006	96/107 (90%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	364..445		68/80 (85%)
frmd6	XP_012824779.1	FERM_F1_FRMD6	15..112	CDD:340718	87/104 (84%)
		B41	20..226	CDD:214604	185/213 (87%)
		FERM_C_FRMD1_FRMD6	219..327	CDD:270006	96/107 (90%)