Protein Alignment FRMD6 and ex

DIOPT Version :10

• Sequence 1: NP_001253975.1
• Gene: FRMD6 / 122786
• HGNCID: 19839
• Length: 622
• Species: Homo sapiens
• Sequence 2: NP_476840.2
• Gene: ex / 33218
• FlyBaseID: FBgn0004583
• Length: 1427
• Species: Drosophila melanogaster
• Alignment Length: 681
• Identity: 153/681 - (22%)
• Similarity: 249/681 - (36%)
• Gaps: 204/681 - (29%)

Human    26 ESLNIIINVKILCHQLLVQVC---DLLRLKDCHLFGLSVIQNNEHVYMELSQKLYKYCPKEWKKE 87
            ::|..:::.|....::..|.|   ....:.|..||||:|:.:.|:::.:...||.||.||.|:..
  Fly    39 KTLYFLVDAKSRVREVYTQTCLHFATQGMLDTELFGLAVLIDGEYMFADPESKLSKYGPKSWRSS 103

Human    88 ASKVRQYEVTWGIDQFGPPMI-IHFRVQYYVENGRLISDRAARYYYYWHLRKQVLHSQCVLR--E 149
            .        |.|:|..|.|:: :|||||:|:|:..::.|..:|:.||..||..:|.......  |
  Fly   104 H--------THGLDANGRPLLELHFRVQFYIESPFMLKDETSRHNYYLQLRHNILQRDLPREQAE 160

Human   150 EAYFLLAAFALQADLG-------NFKRN---------KHYGKYFEPEAYFPSWVVSKR------- 191
            :|...||..|||||||       |.|.:         .:.|:........|.  :|||
  Fly   161 QALVFLAGLALQADLGDAPPGTSNSKDDSGEETSASPSNGGRGLSATTTLPK--ISKRANERMLR 223

Human   192 -----------------------GKDY--ILKHIPN-------------MHKDQFALTASEAHLK 218
                                   |.||  |..::|:             .|::...:..:||.|.
  Fly   224 LSTYVASTSKRETIPLPPSLPPNGADYYRIEDYLPSGLHTPWARSAMRACHREHLGMATAEAELL 288

Human   219 YIKEAVRL-DDVAVHYYRLYKDKREI-EASLTLGLTMRGIQIF----QNLDEEKQLLYDFPWTNV 277
            ||::|..| :.:..|.||:...|.|. ..|....:..:||:|.    .|.....:.. .|.|.|:
  Fly   289 YIQQACSLHETINAHTYRMRLAKSEQGSGSAWFVVYAKGIKILGGESTNSSSNPETT-TFLWPNI 352

Human   278 GKLVFVGKKFEILPDGLPSARKLIYYTGCPMRSRHLLQLLSNSHRLYMNLQPVLRHIRKLEENE- 341
            .||.|..|||||    .....::..|.....:::.||.|..::|:..|.|...|:.:.|.||.|
  Fly   353 TKLSFERKKFEI----RSGESRITLYAASDEKNKLLLTLCKDTHQWSMKLAARLKEVSKREEEEA 413

Human   342 -EKKQYRESYISDNLDLDMDQLEKRSRASGSSAGSMKHKRLSRHSTASHSSSHTSGIEADTKPRD 405
             |.::...||                ..|.|.....|.|...|.|..|.:||:|
  Fly   414 AESQRLHASY----------------ACSRSLLLPYKSKNEQRISVISSTSSNT----------- 451

Human   406 TGPEDSYSSSAIHRKLKTCSSMTSHGSSHTSGVESGGKDRLEEDLQDDEIEMLVD-DPRDLEQMN 469
                                         |||:.|   ||:.   .:||:|:::: .|..|...:
  Fly   452 -----------------------------TSGIVS---DRVH---SEDELEIMINTPPAPLAAPS 481

Human   470 EESLEVSPDMCIYITEDMLMSRKLNGHSGLIVKEI----------GSSTSSSSETVVKLRGQSTD 524
            .|||.::     ::.:...:||:.:....:.:|::          ....||:..|:|.......:
  Fly   482 TESLALA-----HLLDRPSVSRQTSSVGQMSLKDLEEQLAALSVRPQDASSNGATIVTNSSVQRN 541

Human   525 SLPQTICRKPKTSTDRHSLSLDDIRLYQKDFLRIAGLCQDTAQSYTFGCGHELDEEGLYCNSCLA 589
            |: .|......|:||..|...:           |...|..|                  |::.:.
  Fly   542 SM-GTTANDSSTATDSPSSQHN-----------IGSQCSST------------------CSTVVV 576

Human   590 QQCINIQDA------FPVKRTSKYFSLDLTH 614
            ...:|...|      .||..||....|..:|
  Fly   577 TSPVNGAGASSSGAPIPVHSTSSSLELGFSH 607

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FRMD6	NP_001253975.1	FERM_F1_FRMD6	15..120	CDD:340718	30/97 (31%)
		FERM_M	118..234	CDD:459788	40/179 (22%)
		FERM_C_FRMD1_FRMD6	227..335	CDD:270006	29/112 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	364..445		14/80 (18%)
ex	NP_476840.2	FERM_F1_PTPN13_like	25..128	CDD:340621	29/96 (30%)
		B41	27..297	CDD:214604	67/267 (25%)
		FERM_C_FRMD1_FRMD6	298..405	CDD:270006	29/111 (26%)
		PHA03255	512..>681	CDD:165513	22/126 (17%)