Protein Alignment FRMD6 and frmd6

DIOPT Version :10

• Sequence 1: NP_001253975.1
• Gene: FRMD6 / 122786
• HGNCID: 19839
• Length: 622
• Species: Homo sapiens
• Sequence 2: NP_001018652.1
• Gene: frmd6 / 321937
• ZFINID: ZDB-GENE-050522-354
• Length: 616
• Species: Danio rerio
• Alignment Length: 644
• Identity: 450/644 - (69%)
• Similarity: 516/644 - (80%)
• Gaps: 50/644 - (7%)

Human     1 MNKLNFHNNRVMQDRRSVCIFLPNDESLNIIINVKILCHQLLVQVCDLLRLKDCHLFGLSVIQNN 65
            |:||.||||::|||||.||:||||||:||:|::||.:|.:|||||||||||||||||||||||||
Zfish     1 MSKLTFHNNKMMQDRRCVCVFLPNDETLNVIVSVKTVCQELLVQVCDLLRLKDCHLFGLSVIQNN 65

Human    66 EHVYMELSQKLYKYCPKEWKKEASKVRQYEVTWGIDQFGPPMIIHFRVQYYVENGRLISDRAARY 130
            ||:||||.|||.|:||||||:||||        ||||||||||:|||.|||||||||||||.|||
Zfish    66 EHIYMELGQKLSKHCPKEWKREASK--------GIDQFGPPMIVHFRAQYYVENGRLISDRVARY 122

Human   131 YYYWHLRKQVLHSQCVLREEAYFLLAAFALQADLGNFKRNKHYGKYFEPEAYFPSWVVSKRGKDY 195
            |||||||||||.|||:.|||||||||||||||||||||||||:|.||:|||||||||::|||.||
Zfish   123 YYYWHLRKQVLQSQCIQREEAYFLLAAFALQADLGNFKRNKHFGAYFQPEAYFPSWVIAKRGCDY 187

Human   196 ILKHIPNMHKDQFALTASEAHLKYIKEAVRLDDVAVHYYRLYKDKREIEASLTLGLTMRGIQIFQ 260
            ||:|||||||:|||.|||||.|||||||..|||||||||||||||:|::||||||||:|||||||
Zfish   188 ILRHIPNMHKEQFACTASEAQLKYIKEATLLDDVAVHYYRLYKDKKELDASLTLGLTLRGIQIFQ 252

Human   261 NLDEEKQLLYDFPWTNVGKLVFVGKKFEILPDGLPSARKLIYYTGCPMRSRHLLQLLSNSHRLYM 325
            |:...:|||||||||||||||||||:|||||||||||||||||||||:|||||||||||||||||
Zfish   253 NVGTVRQLLYDFPWTNVGKLVFVGKRFEILPDGLPSARKLIYYTGCPLRSRHLLQLLSNSHRLYM 317

Human   326 NLQPVLRHIRKLEENEEKKQYRESYISDNLDLDMDQLEKRSRASGSSAGSMKHKR-LSRHSTASH 389
            ||||||:.:|:|||||||||||||||.|.|:.|||.||:|||||||||||..... .|||||.||
Zfish   318 NLQPVLKQVRRLEENEEKKQYRESYIGDALEADMDHLEQRSRASGSSAGSTSRPNPFSRHSTTSH 382

Human   390 SSSHTSGIEADT--KPRDTGPEDSYSSSAIHRKLKT-CSSMTSHGSSHTSGVESGGKDRLEEDLQ 451
            .||.|||::.|:  .|.:|.          ||.|:| .||.|||.|:||||:||..|   |..|.
Zfish   383 GSSRTSGVDTDSFRTPTNTP----------HRPLRTHSSSNTSHASTHTSGIESSSK---EHCLD 434

Human   452 DDEIEMLVDDPRDLEQMNEESLEVSPDMCIYITEDMLMSRKLNGHSGLIVKEIGSSTSSSSETVV 516
            :||||||||||:..|.:::  ||:|.::||:|||||| |.:.||.|||:|||:.|||||||||||
Zfish   435 EDEIEMLVDDPKSCEDLDD--LELSQELCIHITEDML-SAQNNGCSGLVVKEVSSSTSSSSETVV 496

Human   517 KLRGQSTDSLPQ-TICRKPKTSTDRHSLSLDDIRLYQKDFLRIAGLCQDTAQSYTFGCGHELDEE 580
            ::||||.:.||| |:.||.::||||||.||||:||:|:|....|.||||||.||||||  |.|..
Zfish   497 RMRGQSIECLPQTTMARKGQSSTDRHSQSLDDVRLFQRDCQEWAELCQDTAHSYTFGC--EPDLG 559

Human   581 GLYCNSC----LAQQCINI---QDAFPVKRTSKYFSLDLTHDEV----------PEFVV 622
            |..  .|    ||.||..|   |..||:|||||||||||..:::          |||||
Zfish   560 GTV--GCGYQGLADQCAGIRNNQHPFPIKRTSKYFSLDLDREDLTTGHLTTEAEPEFVV 616

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FRMD6	NP_001253975.1	FERM_F1_FRMD6	15..120	CDD:340718	79/104 (76%)
		FERM_M	118..234	CDD:459788	99/115 (86%)
		FERM_C_FRMD1_FRMD6	227..335	CDD:270006	94/107 (88%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	364..445		43/84 (51%)
frmd6	NP_001018652.1	FERM_F1_FRMD6	15..112	CDD:340718	79/104 (76%)
		B41	20..215	CDD:214604	164/202 (81%)
		FERM_C_FRMD1_FRMD6	219..327	CDD:270006	94/107 (88%)