Protein Alignment FRMD6 and frm-7

DIOPT Version :10

• Sequence 1: NP_001253975.1
• Gene: FRMD6 / 122786
• HGNCID: 19839
• Length: 622
• Species: Homo sapiens
• Sequence 2: NP_506085.2
• Gene: frm-7 / 179687
• WormBaseID: WBGene00001493
• Length: 947
• Species: Caenorhabditis elegans
• Alignment Length: 615
• Identity: 149/615 - (24%)
• Similarity: 245/615 - (39%)
• Gaps: 103/615 - (16%)

Human     7 HNNRVMQDRRSVCIFLPNDESLNIIINVKILCHQLLVQVCDLLRLKDCHLFGLSVIQ-------- 63
            ||.|..|...||...  ..||.::.|:.|...|.:|.:..:.|.|.|..||||:..|
 Worm    37 HNIRPGQTFVSVQTL--TKESFHVAISSKTKVHDVLWKCGERLSLSDDKLFGLAFRQPTEGIGGD 99

Human    64 --NNEHVYMELSQKLYKYCPKE-----WKKEASKVRQYEVTWGIDQFGPPMIIHFRVQYYVENGR 121
              .:|:.:::.:.|:.||..|:     |..::|:.|            |.::::|||:.|::...
 Worm   100 QPRHEYYFLDPAAKIMKYAQKQPRFANWHSKSSENR------------PILVLYFRVRVYIDQVG 152

Human   122 LISDRAARYYYYWHLRKQVLH---SQCVLREEAYFLLAAFALQADLGNFKRNKHYGKYFEPEAYF 183
            |:|...||.:||..|:...|.   .:..:.||..:.:||.||..|.||     .|..||..|.||
 Worm   153 LLSCPKAREHYYLQLKDNFLDHWAGRNSVSEERCWYMAALALITDKGN-----DYLGYFRAEQYF 212

Human   184 PSWVVSKRGKDYILKHIPNMHKDQFALTASEAHLKYIKEAVRLD-DVAVHYYRLYKDKREIEASL 247
            |.||:::||.:||..::|...:|.......:|..|::.||.|.. .:..|.|.|.:.|.:...:.
 Worm   213 PLWVINERGLEYIRNNLPAACEDIINEGRYKAMEKFMIEAGRSPFALNCHLYGLRRHKMDNTDNA 277

Human   248 TLGLTMRGIQIFQ-NLDEEKQLLYDFPWTNVGKLVFVGKKFEIL-PDGLPSARKLIYYTGCPMRS 310
            .||:..:||::.. ..|.::..|....|:.|.||.|..||..|: .||    .|:..|.....::
 Worm   278 VLGINAKGIEMCDIGEDGDRIPLRSLSWSRVAKLSFNRKKMTIIGSDG----TKMSLYAQTEHKA 338

Human   311 RHLLQLLSNSHRLYMNLQPVLRHIRKLEENEEKKQYRESYI------------SDNLDLDMDQLE 363
            ::||:|....|:..:    |:.|:..... ...|.|.|..:            |.:.|.|.|.|
 Worm   339 KYLLELCKAVHQTLL----VMSHLHATMA-PPPKPYLEMSVDGISTSSTSGIGSGDHDKDSDSL- 397

Human   364 KRSRASGSSA-GSMKHKRLSRHSTASHSSSHTSGIEAD-TKPRDTGPEDSYSSSAIHRKLKTCSS 426
              |.|.|... |||..|...|....|:.......:|.| .:......:.|.:|....|.......
 Worm   398 --SSACGDRCHGSMSSKLRLRIKMDSNLDVKIEKMELDHIRQERAASQSSKASDESERSRLEVRH 460

Human   427 MTSHGSSHTSGVES---------------GGKDRLEEDLQDDEIEMLVD---DPRDLEQMNEESL 473
            .|.|.:...||..|               ...|...:.::......:||   :.::.|: :|.|.
 Worm   461 QTYHPAHELSGATSSTYTVTTAQDTATRPSSMDNASQTIESGSSRSIVDVNFNNKNRER-HESST 524

Human   474 EVSPDMCIYITED-------------MLMSRKLNGHSGLIVKEIGSSTSSSSETVVKLRGQS--- 522
            ..|....::.::|             |.||..|:..:...:.:...|.|:|....:..|..|
 Worm   525 STSGTHVLFSSKDATPPIETAVVSSTMSMSVPLDSDTNQSINDRLLSMSASDLRAMAERSYSPPA 589

Human   523 --TDSLPQTICRKPKTSTDRHSLSLDDIRL 550
              |.::|.|....|.....|..|:..:.|:
 Worm   590 QWTTNVPSTGSSSPPEMMARDKLTRSETRI 619

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FRMD6	NP_001253975.1	FERM_F1_FRMD6	15..120	CDD:340718	29/119 (24%)
		FERM_M	118..234	CDD:459788	38/119 (32%)
		FERM_C_FRMD1_FRMD6	227..335	CDD:270006	28/110 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	364..445		19/97 (20%)
frm-7	NP_506085.2	B41	45..269	CDD:214604	69/242 (29%)
		FERM_C_FRMD1_FRMD6	257..362	CDD:270006	28/112 (25%)