DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment OR4L1 and or90d2

DIOPT Version :9

Sequence 1:	NP_001004717.1	Gene:	OR4L1 / 122742	HGNCID:	15356	Length:	312	Species:	Homo sapiens
Sequence 2:	XP_021332980.1	Gene:	or90d2 / 100113432	ZFINID:	ZDB-GENE-070806-27	Length:	309	Species:	Danio rerio

Alignment Length:	294	Identity:	72/294 - (24%)
Similarity:	128/294 - (43%)	Gaps:	36/294 - (12%)

- Green bases have known domain annotations that are detailed below.

Human    27 FFVTFSLIYGATVMGNI--LIMVTVTCRSTLHS-PLYFLLGNLSFLDMCLSTATTPKMIIDLLTD 88
            |...||::..|.::.:|  :.:.....||..|| |.|.|..:|...||.:...:....::.....
Zfish    18 FAKNFSIVLLAVIIISINGMFVFIFFRRSIFHSDPRYILYIHLVMNDMLMVFISVVLFVMTFAWH 82

Human    89 HKTISVWGCVTQMFFMHFFGGAEMTLLIIMAFDRYVAICKPLHYRTIMSHKLLKGFAILSWIIGF 153
            :  :.|..||..:.............|..||.:||:|:|||||:..|.:.:.......|.|.:|.
Zfish    83 N--VPVPFCVLLLLITSVTHRNTPLTLAGMAIERYIAVCKPLHHHQICTVRWTYMLISLIWSVGI 145

Human   154 LHSISQI-VLTMNLPFCGHNVI--NNIFCDLPLVIKLACIETYTLELFVIADSGLLSFTCFILLL 215
            |..::.| :|.:|.|......|  :.|..:.|...:|:.|           .:|:.|...:::|:
Zfish   146 LPGLTDIFLLLINGPLALFTTICTSVILYNTPSHAELSKI-----------SNGIYSSIVWLILV 199

Human   216 VSYIVILVSVPKKSSHGLS--KALSTLSAHIIVVTLFFGPCIFIYVWP-----FSSLASNKTLAV 273
            .:|..::|...:.|::..|  ||.||:..|...:.|    |:..|:.|     ::.|.:.:...:
Zfish   200 YTYCQVMVKAKRSSTNKSSAKKAQSTILLHGAQLLL----CMLSYITPVLDKIYAPLQTEQQKKI 260

Human   274 FY-----TVITP-LLNPSIYTLRNKKMQEAIRKL 301
            .:     |.|.| ||.|.||.:|:|:....|:.|
Zfish   261 NFFNYLLTSILPRLLTPLIYGVRDKQFFNHIKAL 294

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
OR4L1	NP_001004717.1	7tm_4	31..301	CDD:304433	70/288 (24%)
or90d2	XP_021332980.1	7tm_classA_rhodopsin-like	24..283	CDD:320086	65/275 (24%)
		TM helix 1	24..45	CDD:320086	2/20 (10%)
		TM helix 2	53..79	CDD:320086	5/25 (20%)
		TM helix 3	89..119	CDD:320086	8/29 (28%)
		TM helix 4	132..154	CDD:320086	5/21 (24%)
		TM helix 5	179..204	CDD:320086	6/35 (17%)
		TM helix 6	220..247	CDD:320086	9/30 (30%)
		TM helix 7	258..283	CDD:320086	8/24 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000