Protein Alignment C4b and Tep3

DIOPT Version :9

• Sequence 1: XP_006523594.1
• Gene: C4b / 12268
• MGIID: 88228
• Length: 1758
• Species: Mus musculus
• Sequence 2: NP_523507.2
• Gene: Tep3 / 34045
• FlyBaseID: FBgn0041181
• Length: 1469
• Species: Drosophila melanogaster
• Alignment Length: 1698
• Identity: 396/1698 - (23%)
• Similarity: 642/1698 - (37%)
• Gaps: 419/1698 - (24%)

Mouse    14 CASSLQKPRLLLFS---PSVVNLGTPLSVGVQLLDAPPGQEVKGSVFLRNPKGGSCSPKKDFKLS 75
            |.:|.|.    |:|   |:.:...:...|.|.|.:||.....|..:.     |.|.:   |||..
  Fly    23 CQTSAQG----LYSIIAPNTLRPNSQFHVAVSLHNAPESATFKVGIL-----GSSYT---DFKTV 75

Mouse    76 SGDDF--VLLSLEVPLEDVRSCGLFDLRRAPHIQLVAQSPWLRNTAFKATETQGVNLLFSSRRGH 138
            ....|  .||..|:|           ..|....:|.|:.  |....| ..|||   |.|.|::..
  Fly    76 ELRPFSTQLLHFEIP-----------ALRTDRYRLTAEG--LGGVQF-TNETQ---LHFESKQHT 123

Mouse   139 IFVQTDQPIYNPGQRVRYRVFALDQKMRPSTDFLTITVE-NSHGLRVLK--KEIFTSTSIFQDAF 200
            :.||||:.||.||..|.|||..||..::|:..:..:.|: ...|..:::  |:|..:.||:.:..
  Fly   124 VLVQTDKSIYKPGDLVHYRVLILDANLKPARGYGRVHVDIKDSGDNIIRSYKDIRLTNSIYSNEL 188

Mouse   201 TIPDISEPGTWKISARFSDGLESNRSTHFEVKKYVLPNFEVKITPWKPYILMVPSNSDEIQLDIQ 265
            .:.|....|||.|....||   ...:..||:..::||.|.|.|...|..|.    ...:|...::
  Fly   189 RLSDSPRFGTWSIVVDVSD---QEHTQTFEILDHILPKFVVDIDTPKHAIY----KDGKIAATVR 246

Mouse   266 ARYIYGKPVQGVA----YTRFALMDEQGKRTFLRGLETQAKL-VEGRTHISISKDQFQAALDKIN 325
            |.|.:|:|:.|.|    |..|.    ...:.|:..|.|:..: ::|..:.....:      ::::
  Fly   247 AHYAFGQPIVGEATLSIYPTFF----GSLQPFVNDLITRKVVPIDGNAYFEFDIE------NELH 301

Mouse   326 IGVRDLEGLRLYAATAVIESPGGEMEEAELTSWRFVSSAFSLDLS-------RTKRHLVPGAHFL 383
            : .:|.|  |.|...|::       ||....|.:..|:..:|.|:       :...:.:||..|.
  Fly   302 L-KQDYE--RQYLLDALV-------EEKSTGSVQNYSTVLTLHLNHYRVEAVKVPSYYIPGVPFE 356

Mouse   384 LQALVQEMSGSEASNVPVKVSA--TLVSGSDSQVLDIQQSTNGIGQVSISFPIP--------PTV 438
            ..|.:....|.:..:...:::|  |.|.||.........|.:..|::.:.|.:|        ..:
  Fly   357 ATARIARNDGGQLRDFNPQITAYLTNVYGSSEMYNRTAYSLDASGEIKMKFTVPIGDRDEFHSII 421

Mouse   439 TELRLLVS-AGSLYPAIARLTVQAPPSR---GTGFLSIEPLDPRSPSVGDTFILNLQPVGIPAPT 499
            .:.:.::| .|.:            ||:   ...:::.:.|:.| |:|.       |.:.:...:
  Fly   422 VDYQGVISEVGKI------------PSKHLHSKNYITAKVLNDR-PTVN-------QEISVVVRS 466

Mouse   500 FS---HYYYMIISRGQI-------MAMGREPRKTVTSVSVLVDHQLAPSFYFVAYFYHQGHPVAN 554
            |:   ::.|.::.||.|       :|.|     |..::..|....:.|....:.|....|..|.:
  Fly   467 FAPIKYFMYQVVGRGDIILSRNVDVAPG-----TFHTIKFLASFAMMPRANLLVYTVIDGEFVYD 526

Mouse   555 SLLINIQSRDCEGKLQ-LKVDGAKEYRNADMMKLRIQTDSKALVALGAVDMALYAVGGRSHKPLD 618
            ..:|.::    |..|. ::||..........:.:.|.|...:.|.|..||.  .|...||...|.
  Fly   527 EQVIQLE----ENLLNAVQVDAPIRAPPGQDIDIGISTKPYSYVGLMLVDQ--NANDLRSGHDLT 585

Mouse   619 MSKVFEVINSY-----NVGCGPGGGDDALQVFQDAGLAFSDGDRLTQTREDLSCPKEKKSRQKRN 678
            ..::.:.:.||     |...|..|        :::|:       :|.:..|....||.:|    |
  Fly   586 HKRLMDALRSYELSDVNTPMGSPG--------KESGV-------ITMSNTDYFIEKEAES----N 631

Mouse   679 VNFQKAVS-----EKLGQYSSPDAKRCCQDGMTKLPMKRTCEQRAARVPQQACREPFLSCCKFAE 738
            ....:.||     :||......|.....:..:..||..:      .|.......:||..
  Fly   632 PALDREVSTGPEEDKLTTVRKTDIGPAHKIEVNTLPPGK------GRYAFSYTPKPFWH------ 684

Mouse   739 DLRRNQTRSQAHLARNNHNMLQEEDLIDEDDILVRTSFPENWLWRVEPVDSSKLLTVW--LPDSM 801
                   ..:.|:.|:.                     .:.||:......|....::.  :|..|
  Fly   685 -------NPRVHVMRDP---------------------ADTWLFLNISASSDGRNSIHRRIPSEM 721

Mouse   802 TTWEIHGVSLSKSKGLCVAKPT-RVRVFRKFHLHLRLPISIRRFEQFELRPVLYNYLNDDVAVSV 865
            |:|.:...:|....||.::.|. ::..:::|::...||.||:|.|...:..|::|  |.|..::|
  Fly   722 TSWVVSAFALDPVNGLGLSPPNGKLEAYKEFYISTELPYSIKRDELIAIPFVVHN--NRDSDLNV 784

Mouse   866 HVT--------------------PVEGLCLAGGGMMAQQVTVPAGSARPVAFSVVPTAAANVPLK 910
            .||                    |...|      ...:.:.||..|||.|:|.|.|.....:.:|
  Fly   785 EVTFYNSALDFDFPQLDPKATNQPKVEL------YRRRSLQVPGRSARSVSFIVTPKRVGPLLVK 843

Mouse   911 VVARGVFDLGDAVSKILQIEKEGAIHREELVY----NLDPLNNLGRTLEIPGSSDPNIVPDGDFS 971
            .:|.. ...||.|.:.|.:|..||:.|....:    |.:..|....|:.:|    .|.:|:.
  Fly   844 AMAAS-SQAGDTVEQNLLVEHPGAMERINRGFLFELNSNAQNRRNVTIAVP----RNAIPES--- 900

Mouse   972 SLVRVTASEPLETMGSEGALSPGGVASLLRLPQGCAEQTMIYLAPTLTASNYLDRTEQWSKLSPE 1036
              .|:..|...:.:||    ..|.:.||:.||.||.||||:...|.|....||.|..|   |:||
  Fly   901 --TRIEVSAVGDLIGS----LVGNLDSLILLPTGCGEQTMVNFVPNLIVLRYLGRLRQ---LTPE 956

Mouse  1037 TKDHAVDLIQKGYMRIQQFRKNDGSFGAW---LHRDSSTWLTAFVLKILSLAQEQVGNSPEKLQE 1098
            .:..|.:.:..||.||..:|..:|:|.|:   :.| |||||||:|.:.|..|..........||:
  Fly   957 VELRATNNLAIGYQRILYYRHENGAFSAFGLDIKR-SSTWLTAYVARSLRQAAPFTQVDSNVLQK 1020

Mouse  1099 TASWLLAQQLGDGSFHDPCPVIHRAMQGGLVGSDETVALTAFVVIALHHGLDVFQDDDAKQLKNR 1163
            ..::|.:.|..:|.|.:...|..|.       .|:.::|||||.:||...:|::     .:.:|
  Fly  1021 ALTYLGSVQSANGGFEERGDVFERF-------GDDGISLTAFVTLALMENVDLY-----PEYRN- 1072

Mouse  1164 VEASITKANSFLGQKASAGLLGA---HAAAITAYALTLTKASEDLRNVAHNSLMAMAEETGEHLY 1225
               :|.||..|:    :.||.|:   ||.||..|  .|::|:.:.:......|.:||.......:
  Fly  1073 ---NINKALDFI----TRGLDGSSNLHAMAIGTY--VLSRANHNAKAAFLQRLDSMATNKDGLKW 1128

Mouse  1226 WGLVLGSQDKVVLRPTAPRSPTEPVPQAPALW--------IETTAYALLHLLLREGKGKMADKAA 1282
            |                  :.|.|..:..:.|        ||.:|||.|.||.....|. |....
  Fly  1129 W------------------NKTAPAGEQQSPWYNATRSVNIEISAYAALALLENNLVGD-ALPVL 1174

Mouse  1283 SWLTHQGSFHGAFRSTQDTVVTLDALSAYWIASHTTEEKALNVTLSSMGRNGLKTHGLHLNNHQV 1347
            :||..|.:..|.|.::|||||.|.||..:       .|:     .||.|.|      |.:..|..
  Fly  1175 NWLMDQRNPKGGFVASQDTVVGLQALLMF-------AER-----FSSQGNN------LQIGFHYG 1221

Mouse  1348 KGLEE---------------ELKFSLGSTISVKVEGNSKGTLKILRTYNVLDMKNTTCQDLQIEV 1397
            :|.|.               ||..:| ..:||...|......::..|||.    |.|.
  Fly  1222 EGAETIINVNAENSLALQTVELPNNL-KNLSVSATGRGMALAQVSYTYNT----NVTS------- 1274

Mouse  1398 KVTGAVEYAWDA--------NEDYEDYYDMPAADDPSVPLQPVTPLQLFEGRRSRRRREAPKVVE 1454
                    ||..        ...:.||..:.|.                        .....||.
  Fly  1275 --------AWPRFVLDPTVNRNSHADYLHLSAC------------------------ASFVSVVG 1307

Mouse  1455 EQESRVQYTVCIWRNGKLGLSGMAIADITLLSGFHALRADLEKLTSLSDRYVSHFETDGPH--VL 1517
            |.|.|               |.||:.::.|.|||...|..|..|.| |:| :...||...:  |:
  Fly  1308 ENEQR---------------SNMAVMEVHLPSGFVVDRDTLPTLES-SER-IKKVETQNRNTKVV 1355

Mouse  1518 LYFDSVPTTRECVGFGASQEVVVGLVQPSSAVLYDYYSPDHKCSVFYAAPTKSQLLATLCS---- 1578
            :|||.:.....|....|.:.|.|...:|.:.|:||||....:...||.||..:  :..:|.
  Fly  1356 IYFDYLDRREVCPTLHAYKTVKVTKHRPVAVVMYDYYDSARRARQFYRAPKSN--ICDICEHANC 1418

Mouse  1579 GDVCQCAE 1586
            ||:|:.||
  Fly  1419 GDLCEKAE 1426

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
C4b	XP_006523594.1	A2M_N	139..231	CDD:376626	29/94 (31%)
		MG3	233..318	CDD:375334	20/89 (22%)
		A2M_N_2	470..609	CDD:377903	29/149 (19%)
		ANATO	686..752	CDD:237984	10/70 (14%)
		A2M	780..867	CDD:365945	23/89 (26%)
		A2M_comp	978..1311	CDD:369461	105/346 (30%)
		A2M_recep	1475..1564	CDD:369460	29/90 (32%)
		NTR_like	1582..1736	CDD:382999	3/5 (60%)
Tep3	NP_523507.2	A2M_N	124..215	CDD:280081	28/93 (30%)
		A2M_N_2	448..573	CDD:285005	28/141 (20%)
		A2M	697..787	CDD:278630	23/91 (25%)
		A2M_2	918..1203	CDD:239227	101/329 (31%)
		A2M_comp	967..1200	CDD:284982	79/274 (29%)
		A2M_recep	1313..1402	CDD:284981	29/90 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840024
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11412
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.810