DRSC/TRiP Functional Genomics Resources

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Protein Alignment C3 and Tep1

DIOPT Version :9

Sequence 1:NP_033908.2 Gene:C3 / 12266 MGIID:88227 Length:1663 Species:Mus musculus
Sequence 2:NP_523578.1 Gene:Tep1 / 34937 FlyBaseID:FBgn0041183 Length:1354 Species:Drosophila melanogaster


Alignment Length:1619 Identity:399/1619 - (24%)
Similarity:654/1619 - (40%) Gaps:387/1619 - (23%)


- Green bases have known domain annotations that are detailed below.


Mouse    11 VLLLLLASSPL-------ALGIPMYSIITPNVLRLESEETIVLEAHDAQGDIPVTVTVQDFLKRQ 68
            :|.|:|:|:.|       |.|  :||::.|..||..|...:|:..|:......|:|:        
  Fly     1 MLWLILSSTILHCVLLSNANG--LYSVLAPKTLRSNSAYNVVVAIHNTTRTTEVSVS-------- 55

Mouse    69 VLTSEKTVLTGASGHLRS-VSIKIPASKEFNSD----KEGHKYVTVVANFGETVVEKAVMVSF-- 126
                    |||.|.:.|. |.::..:||....|    .|| .|...|...|....:.:..:||  
  Fly    56 --------LTGPSLNSRKYVDVQSMSSKSVRFDIPKLTEG-DYELKVMGSGGIEFQNSTKLSFAP 111

Mouse   127 QSGYLFIQTDKTIYTPGSTVLYRIFTVDNNLLPVGKTVVILIETPDG----IPVKRDILSSNNQH 187
            ...:|:||:||..|.||..:.:|:..:|.|..|......|.||..||    |...:||..:...:
  Fly   112 DLNWLYIQSDKATYKPGDKIQFRVLFLDKNTRPAVIDKPIKIEIRDGDQNLIKSWKDIKPAKGVY 176

Mouse   188 -GILPLSWNIPELVNMGQWKIRAFYEHAPKQIFSAEFEVKEYVLPSFEVRVEPTETFY----YID 247
             |.|.|| :.|.|   |.|.:.|..:...|  .:....|.:||:|.|||.|...:...    || 
  Fly   177 SGELQLS-DRPVL---GNWTVTATVQDEGK--VTNVLVVDKYVVPKFEVVVLTAKNVAASAGYI- 234

Mouse   248 DPNGLEVSIIAKFLYGKNVDGTAFVIFGVQ----------DGDKKISLAHSLTRVVIEDGVGDAV 302
                 ..:|.|::.:.|.|.|  .|:..::          ||:..:....|.|            
  Fly   235 -----RATIKARYTFKKPVKG--HVVATIEGSSTEQSLPIDGEVNVEFPISAT------------ 280

Mouse   303 LTRKVLMEGVRPSNADALVGKSLYVSVTVILHSGSDMVEAERSGIPIVTSPYQIHFTKTPKFFKP 367
             .:::|       ...|:|.:.|    |.|.|:|:..|...:       ..:::.....|..::|
  Fly   281 -AKRLL-------KITAIVTEEL----TDIKHNGTAYVTVHQ-------HRHKLEDLFWPTHYRP 326

Mouse   368 AMPFDLMVFVTNPDGSP---ASK-----VLVVTQGSNAKALTQDDGVAKLSINTPNSRQPLTITV 424
            .:..:....|.|.||||   :||     ||......|..|..|:                   ::
  Fly   327 GVSSEFKTVVRNLDGSPVMDSSKMVNFNVLCCQVSKNFSASLQN-------------------SI 372

Mouse   425 RTKKDTLPESRQA---TKTMEAHPYSTMHNSNNYLH-----LSVSRMELKPGDNLNVNFHLRTDP 481
            .|:...|||:.|:   |.|     :.|..|...|::     |.::....||.....:..::.:| 
  Fly   373 ATEHIMLPETCQSCLVTST-----FDTAENIERYIYKLNKPLMIAINTKKPQLRKLLKINIISD- 431

Mouse   482 GHEAKIRYYTYLVMNKGKL-LKAGRQVREPGQDLVVLSLPITPEFIPSFRLV------AYYTLIG 539
               ..:.|:...|:.:|.: |...::::|..:...:       ||.|:|.||      .:|.:.|
  Fly   432 ---TYLPYFILTVVARGNIVLSLFQEMKEKKKSQEI-------EFEPTFALVPQATIFVHYIIDG 486

Mouse   540 ASGQREVVADSVWVDVKDSCIGTLVVKGDPRDNHLAPGQQTTLRIEGNQGARVGLVAVDKGVFVL 604
            .     :::|...||::.....|:.:.   ..|...|..:.:|:::.|..:.|||:.||:.|.:|
  Fly   487 V-----LMSDEKTVDIERDFENTIEIL---TTNEALPRDEVSLKVKTNPHSFVGLLGVDQSVLLL 543

Mouse   605 NKKNKLTQSKIWD----------VVEKADIGCTPGSGKNYAGVFMDAGLAFKTSQGLQTEQRADL 659
            ...|.|.:..|.:          ::..|:|.....||                            
  Fly   544 RSGNDLNRDLILNNLATYSTDLVILTNANINIYRSSG---------------------------- 580

Mouse   660 ECTKPAARRRRSVQLMERRMDKAGQYTDKGLRKCCEDGMRDIPMRYSCQRRARLITQGENCIKAF 724
                                   |.||:.|...|                ...||  |....|  
  Fly   581 -----------------------GCYTNPGYTNC----------------TGSLI--GRTMFK-- 602

Mouse   725 IDCCNHITKLREQHRRDHVLGLARSELEEDIIPEEDIISRSHFPQSWLWTIEELKEPEKNGISTK 789
                |..||   ......::|..|::..   :|.    .|..||::||::  .:.:...||  ..
  Fly   603 ----NEPTK---NSGPVPIVGSTRAQAS---LPP----VRKLFPETWLFS--NITDVGANG--EY 649

Mouse   790 VMNIFLKDSITTWEILAVSLSDKKGICVA-DPYEIRVMQDFFIDLRLPYSVVRNEQVEIRAVLFN 853
            ::...:.|::|:|.|...|||.:.|:.|. :|..|||.|.|||...|||||.|.|.:.|..::||
  Fly   650 IIKETVPDTLTSWVITGFSLSPQSGLAVTRNPSRIRVFQPFFITTNLPYSVKRGEVIAIPVIVFN 714

Mouse   854 YREQEELKVRVELLHNP----AFCSMATAKN--------RYFQTIKIPPKSSVAVPYVIVPLKIG 906
            |... ::|.:| |:.|.    .|.. .|.||        |..:|:.||..:...:.::|.|.|:|
  Fly   715 YLGM-DVKAKV-LMDNSDGQYEFIE-TTNKNVSQYLRGVRRKKTLWIPANTGRGISFMIRPKKVG 776

Mouse   907 QQEVEVKAAVFNHFISDGVKKTLKVVPEGMR--INKTVAIHT--------LDPEKLGQGGVQKVD 961
            ...:::.|  .:.:..|.:.:.|||..:|::  :||.|.|:.        ..|||       .:.
  Fly   777 LTTLKITA--ISKYAGDRLHQILKVEADGVQKYVNKAVLINVQRLNRRSLAPPEK-------TII 832

Mouse   962 VPAADLSDQVPDTDSETRIILQGSPVVQM----AEDAVDGERLKHLIVTPAGCGEQNMIGMTPTV 1022
            :..||             .:::||..|:.    ...|...|.|..|:..|.|||||||....|::
  Fly   833 IEKAD-------------NVIEGSETVEFEVCGTSQAPQLEHLDDLVHLPCGCGEQNMFNFVPSI 884

Mouse  1023 IAVHYLDQTEQWEKFGIEKRQEALELIKKGYTQQLAFKQPSSAYAAFNNRPP--STWLTAYVVKV 1085
            :|:.||....:.::   |...:|...::.||..:|.:|:...:::|:.....  ||||||||::.
  Fly   885 LALSYLKAKNRQDQ---EIENKAKRYVETGYQIELNYKRNDGSFSAWGQHDALGSTWLTAYVIRS 946

Mouse  1086 FSLAANLIAIDSHVLCGAVKWLILEKQKPDGVFQEDGPVIHQEMIGGFRNAKEADVSLTAFVLIA 1150
            |..||..|.||.:||...:.:|: .:|..||.|:|.|.|||        |:..:.::||:|||:.
  Fly   947 FHQAAKYIDIDKNVLVAGLDFLV-SRQSTDGKFKELGMVIH--------NSHGSPLALTSFVLLT 1002

Mouse  1151 LQEARDICEGQVNSLPGSINKAGEYIEASYMNLQRPYTVAIAGYALAL---------MNKLEEPY 1206
            ..|.    |..:......|::|.|::.........||.:|||..||:|         ::||:   
  Fly  1003 FFEN----EEYMPKYKHVIDRAVEFVVTEVHQSNEPYDLAIAALALSLARNRNAYKVLDKLD--- 1060

Mouse  1207 LGKFLNTAKDRNRWEEPDQ-QLYNVEATSYALLALLLLKDFDSVPPVVRWLNEQRYYGGGYGSTQ 1270
              |......|...|...|: :...||.|||.|||||.....|...|:|.||..:|...||:.|:|
  Fly  1061 --KLATRRGDHKWWTGSDKCKSSEVETTSYVLLALLEHNISDEPKPIVDWLISKRNSNGGFVSSQ 1123

Mouse  1271 ATFMVFQALAQYQTDVPDHKDLN-MDVSF-HLPSRSSATTFRLLWENGNLLRSEETKQN-EAFSL 1332
            .|.:...||.:|  ::..|.... :|:.| ||  .......|:..||...:::.:..:| ....|
  Fly  1124 DTVVGIMALTKY--ELQSHASTEAIDIEFWHL--NEDKKHVRVTKENEFKVQTHQLPENTNEVKL 1184

Mouse  1333 TAKGKGRGTLSVVAVYHAKLKSKVTCKKFDLRVSIRPAPETAKKPEEAKNTMFLEICTKYL---- 1393
            .|||:||.  .|...|...:.:|.....|.|..:::         :..|..:.|.||..|.    
  Fly  1185 LAKGQGRA--QVQLTYRYNVATKEARPSFKLTTTVK---------KSHKGRLILGICGTYTPIAA 1238

Mouse  1394 --GDVDATMSILDISMMTGFAPDTK---DLELLASGVDRYISKYEMNKAFSNKNTLI-IYLEKIS 1452
              .:....|:::.:.:.:|:..|.:   |:|.: |.|.|..:|        |::|.: ||.||:|
  Fly  1239 SERNKTTNMALMQVQLPSGYVCDIEPFADIEAI-SDVKRVETK--------NEDTEVHIYFEKLS 1294

Mouse  1453 HTEEDCLTFKVHQYFNVGLIQPGSVKVYSYYNLEESCTRFYHPEKDDGMLSKLCHSEMC 1511
            ..:..|||.:......|..::|..|::|.||..|.|.|.|||.   |..|..:||...|
  Fly  1295 PGDRKCLTLEAIYTHAVANLKPSWVRLYDYYATERSATEFYHV---DTSLCDICHGNEC 1350

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
C3NP_033908.2 A2M_N 130..225 CDD:280081 30/99 (30%)
A2M_N_2 458..603 CDD:285005 31/151 (21%)
ANATO 678..747 CDD:237984 13/68 (19%)
A2M 770..866 CDD:278630 34/96 (35%)
complement_C3_C4_C5 996..1282 CDD:239226 96/297 (32%)
A2M_comp 1051..1282 CDD:284982 79/242 (33%)
A2M_recep 1398..1493 CDD:284981 28/98 (29%)
NTR_complement_C3 1513..1661 CDD:239638
Interaction with CFP/properdin. /evidence=ECO:0000250|UniProtKB:P01024 1634..1659
Tep1NP_523578.1 A2M_N 116..201 CDD:280081 29/88 (33%)
A2M_N_2 411..542 CDD:285005 30/149 (20%)
A2M 634..726 CDD:278630 34/97 (35%)
A2M_2 859..1135 CDD:239227 96/296 (32%)
A2M_comp 910..1135 CDD:284982 79/242 (33%)
A2M_recep 1245..1335 CDD:284981 28/98 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167840027
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2373
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11412
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
54.800

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