DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment C3 and Tep3

DIOPT Version :9

Sequence 1:NP_033908.2 Gene:C3 / 12266 MGIID:88227 Length:1663 Species:Mus musculus
Sequence 2:NP_523507.2 Gene:Tep3 / 34045 FlyBaseID:FBgn0041181 Length:1469 Species:Drosophila melanogaster


Alignment Length:1613 Identity:380/1613 - (23%)
Similarity:650/1613 - (40%) Gaps:312/1613 - (19%)


- Green bases have known domain annotations that are detailed below.


Mouse     9 LLVLLLLLASSPLALGIPMYSIITPNVLRLESEETIVLEAHDAQGDIPVTVTVQDFLKRQVLTSE 73
            :||...||..:. |.|  :||||.||.||..|:..:.:..|:|    |.:.|.:..:.....|..
  Fly    15 ILVTACLLCQTS-AQG--LYSIIAPNTLRPNSQFHVAVSLHNA----PESATFKVGILGSSYTDF 72

Mouse    74 KTVLTGASGHLRSVS-----IKIPASKEFNSDKEGHKYVTVVANFGETVVEKAVMVSFQSGY--L 131
            |||      .||..|     .:|||.:.       .:|.......|.........:.|:|..  :
  Fly    73 KTV------ELRPFSTQLLHFEIPALRT-------DRYRLTAEGLGGVQFTNETQLHFESKQHTV 124

Mouse   132 FIQTDKTIYTPGSTVLYRIFTVDNNLLPV---GKTVVILIETPDGIPVK--RDILSSNNQHGILP 191
            .:||||:||.||..|.||:..:|.||.|.   |:..|.:.::.|.| ::  :||..:|:   |..
  Fly   125 LVQTDKSIYKPGDLVHYRVLILDANLKPARGYGRVHVDIKDSGDNI-IRSYKDIRLTNS---IYS 185

Mouse   192 LSWNIPELVNMGQWKIRAFYEHAPKQIFSAEFEVKEYVLPSFEVRVEPTETFYYIDDPNGLEVSI 256
            ....:.:....|.|.|   ......|..:..||:.:::||.|.|.::..:...|.|  ..:..::
  Fly   186 NELRLSDSPRFGTWSI---VVDVSDQEHTQTFEILDHILPKFVVDIDTPKHAIYKD--GKIAATV 245

Mouse   257 IAKFLYGKNVDGTAFV-----IFGVQDGDKKISLAHSLTRVVIEDGVGDAVLTRKVLMEGVRPSN 316
            .|.:.:|:.:.|.|.:     .||                 .::..|.| ::||||:     |.:
  Fly   246 RAHYAFGQPIVGEATLSIYPTFFG-----------------SLQPFVND-LITRKVV-----PID 287

Mouse   317 ADALVGKSLYVSVTV--ILHSGSD---------MVEAERSG--------IPIVTSPYQIHFTKTP 362
            .:|      |....:  .||...|         :||.:.:|        :.:..:.|::...|.|
  Fly   288 GNA------YFEFDIENELHLKQDYERQYLLDALVEEKSTGSVQNYSTVLTLHLNHYRVEAVKVP 346

Mouse   363 KFFKPAMPFDLMVFVTNPDGS-------PASKVLVVTQGS----NAKALTQD-DGVAKLSINTP- 414
            .::.|.:||:....:...||.       ..:..|....||    |..|.:.| .|..|:....| 
  Fly   347 SYYIPGVPFEATARIARNDGGQLRDFNPQITAYLTNVYGSSEMYNRTAYSLDASGEIKMKFTVPI 411

Mouse   415 NSRQPLTITVRTKKDTLPESRQATKTMEAHPYSTMHNSNNYLHLSVSRMELKPGDNLNVNFHLRT 479
            ..|......:...:..:.|..:.       |...:| |.||:...|  :..:|..|..::..:|:
  Fly   412 GDRDEFHSIIVDYQGVISEVGKI-------PSKHLH-SKNYITAKV--LNDRPTVNQEISVVVRS 466

Mouse   480 DPGHEAKIRYYTYLVMNKGKLLKAGRQVREPGQDLVVLSLPITPEFIPSFRL-----VAYYTLIG 539
                .|.|:|:.|.|:.:|.::.:......||....:       :|:.||.:     :..||:|.
  Fly   467 ----FAPIKYFMYQVVGRGDIILSRNVDVAPGTFHTI-------KFLASFAMMPRANLLVYTVID 520

Mouse   540 ASGQREVVADSVWVDVKDSCIGTLVVKGDPRDNHLAPGQQTTLRIEGNQGARVGLVAVDKGVFVL 604
            .    |.|.|...:.::::.:..:.|....|   ..|||...:.|.....:.|||:.||:....|
  Fly   521 G----EFVYDEQVIQLEENLLNAVQVDAPIR---APPGQDIDIGISTKPYSYVGLMLVDQNANDL 578

Mouse   605 NKKNKLTQSKIWDVV---EKADIGCTPGS-GKNYAGVFMDAGLAFKTSQGLQTEQRADLECTKPA 665
            ...:.||..::.|.:   |.:|:....|| ||       ::|:...::.....|:.|:   :.||
  Fly   579 RSGHDLTHKRLMDALRSYELSDVNTPMGSPGK-------ESGVITMSNTDYFIEKEAE---SNPA 633

Mouse   666 ARRRRSVQLMERRMDKAGQYTDKGLRKCCEDGMRDIPM---RYSCQRRARLITQGENCIKAFIDC 727
            ..|..|....|.::... :.||.|.....|  :..:|.   ||                 ||   
  Fly   634 LDREVSTGPEEDKLTTV-RKTDIGPAHKIE--VNTLPPGKGRY-----------------AF--- 675

Mouse   728 CNHITKLREQHRRDHVLGLARSELEEDIIPEEDIISRSHFPQSWLWTIEELKEPEKNGISTKVMN 792
             ::..|....:.|.||:   |...:                 :||:.........:|.|..::  
  Fly   676 -SYTPKPFWHNPRVHVM---RDPAD-----------------TWLFLNISASSDGRNSIHRRI-- 717

Mouse   793 IFLKDSITTWEILAVSLSDKKGICVADPY-EIRVMQDFFIDLRLPYSVVRNEQVEIRAVLFNYRE 856
               ...:|:|.:.|.:|....|:.::.|. ::...::|:|...||||:.|:|.:.|..|:.|.|:
  Fly   718 ---PSEMTSWVVSAFALDPVNGLGLSPPNGKLEAYKEFYISTELPYSIKRDELIAIPFVVHNNRD 779

Mouse   857 QEELKVRVELLHN------PAFCSMATAKNRY----FQTIKIPPKSSVAVPYVIVPLKIGQQEVE 911
             .:|.|.|...::      |.....||.:.:.    .:::::|.:|:.:|.:::.|.::|  .:.
  Fly   780 -SDLNVEVTFYNSALDFDFPQLDPKATNQPKVELYRRRSLQVPGRSARSVSFIVTPKRVG--PLL 841

Mouse   912 VKAAVFNHFISDGVKKTLKVVPEGM--RINKTVAIHTLDPEKLGQGGVQKVDVPAADLSDQVPDT 974
            |||...:....|.|::.|.|...|.  |||:....      :|......:.:|..|...:.:|::
  Fly   842 VKAMAASSQAGDTVEQNLLVEHPGAMERINRGFLF------ELNSNAQNRRNVTIAVPRNAIPES 900

Mouse   975 DSETRIILQGSPVVQMAEDAVDGERLKHLIVTPAGCGEQNMIGMTPTVIAVHYLDQTEQWEKFGI 1039
               |||  :.|.|..:....|.  .|..||:.|.|||||.|:...|.:|.:.||.:..|...   
  Fly   901 ---TRI--EVSAVGDLIGSLVG--NLDSLILLPTGCGEQTMVNFVPNLIVLRYLGRLRQLTP--- 955

Mouse  1040 EKRQEALELIKKGYTQQLAFKQPSSAYAAF--NNRPPSTWLTAYVVKVFSLAANLIAIDSHVLCG 1102
            |....|...:..||.:.|.::..:.|::||  :.:..||||||||.:....||....:||:||..
  Fly   956 EVELRATNNLAIGYQRILYYRHENGAFSAFGLDIKRSSTWLTAYVARSLRQAAPFTQVDSNVLQK 1020

Mouse  1103 AVKWLILEKQKPDGVFQEDGPVIHQEMIGGFRNAKEADVSLTAFVLIALQEARDICEGQVNSLPG 1167
            |:.:| ...|..:|.|:|.|.|        |....:..:||||||.:||.|..|:.....|    
  Fly  1021 ALTYL-GSVQSANGGFEERGDV--------FERFGDDGISLTAFVTLALMENVDLYPEYRN---- 1072

Mouse  1168 SINKAGEYIEASYMNLQRPYTVAIAGYALALMN-KLEEPYLGKF--LNTAKDRNRW-------EE 1222
            :||||.::|..........:.:||..|.|:..| ..:..:|.:.  :.|.||..:|       .|
  Fly  1073 NINKALDFITRGLDGSSNLHAMAIGTYVLSRANHNAKAAFLQRLDSMATNKDGLKWWNKTAPAGE 1137

Mouse  1223 PDQQLY------NVEATSYALLALLLLKDFDSVPPVVRWLNEQRYYGGGYGSTQATFMVFQALAQ 1281
            .....|      |:|.::||.||||.........||:.||.:||...||:.::|.|.:..|||..
  Fly  1138 QQSPWYNATRSVNIEISAYAALALLENNLVGDALPVLNWLMDQRNPKGGFVASQDTVVGLQALLM 1202

Mouse  1282 YQTDVPDHKDLNMDVSFHLPSRSSATTFRLLWENGNLLRSEETKQN-EAFSLTAKGKGRGTLSVV 1345
            :........: |:.:.||. ...:.|...:..||...|::.|...| :..|::|.|:|.....|.
  Fly  1203 FAERFSSQGN-NLQIGFHY-GEGAETIINVNAENSLALQTVELPNNLKNLSVSATGRGMALAQVS 1265

Mouse  1346 AVYHAKLKSKVTCKKFDLRVSIRPAPETAKKPEEAKNT----MFLEICTKYLGDVD-----ATMS 1401
            ..|:..:.|              ..|.....|...:|:    :.|..|..::..|.     :.|:
  Fly  1266 YTYNTNVTS--------------AWPRFVLDPTVNRNSHADYLHLSACASFVSVVGENEQRSNMA 1316

Mouse  1402 ILDISMMTGFAPDTKDLELLASGVDRYISKYEMNKAFSNKNT-LIIYLEKISHTEEDCLTFKVHQ 1465
            ::::.:.:||..|...|..|.|  ...|.|.|.    .|:|| ::||.:.:.. .|.|.|...::
  Fly  1317 VMEVHLPSGFVVDRDTLPTLES--SERIKKVET----QNRNTKVVIYFDYLDR-REVCPTLHAYK 1374

Mouse  1466 YFNVGLIQPGSVKVYSYYNLEESCTRFYHPEKDDGMLSKLCHSEMCRCAEENC 1518
            ...|...:|.:|.:|.||:......:||...|     |.:|..    |...||
  Fly  1375 TVKVTKHRPVAVVMYDYYDSARRARQFYRAPK-----SNICDI----CEHANC 1418

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
C3NP_033908.2 A2M_N 130..225 CDD:280081 28/101 (28%)
A2M_N_2 458..603 CDD:285005 32/149 (21%)
ANATO 678..747 CDD:237984 13/71 (18%)
A2M 770..866 CDD:278630 25/96 (26%)
complement_C3_C4_C5 996..1282 CDD:239226 95/303 (31%)
A2M_comp 1051..1282 CDD:284982 78/248 (31%)
A2M_recep 1398..1493 CDD:284981 24/95 (25%)
NTR_complement_C3 1513..1661 CDD:239638 3/6 (50%)
Interaction with CFP/properdin. /evidence=ECO:0000250|UniProtKB:P01024 1634..1659
Tep3NP_523507.2 A2M_N 124..215 CDD:280081 27/97 (28%)
A2M_N_2 448..573 CDD:285005 31/144 (22%)
A2M 697..787 CDD:278630 24/95 (25%)
A2M_2 918..1203 CDD:239227 95/300 (32%)
A2M_comp 967..1200 CDD:284982 76/245 (31%)
A2M_recep 1313..1402 CDD:284981 24/95 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167840028
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2373
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11412
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
54.800

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