Protein Alignment C3 and Tep2

DIOPT Version :9

• Sequence 1: NP_033908.2
• Gene: C3 / 12266
• MGIID: 88227
• Length: 1663
• Species: Mus musculus
• Sequence 2: NP_523506.1
• Gene: Tep2 / 34044
• FlyBaseID: FBgn0041182
• Length: 1420
• Species: Drosophila melanogaster
• Alignment Length: 1645
• Identity: 404/1645 - (24%)
• Similarity: 667/1645 - (40%)
• Gaps: 394/1645 - (23%)

Mouse    22 ALGIPMYSIITPNVLRLESEETIVLEAHDAQGDIPVTVTVQDFLKRQVLTSEKTVLTGASGHLRS 86
            |.||  ||::.|..||..|:..:|:..|.|.|...:.|:                |.|.| :..:
  Fly    19 ATGI--YSVVGPGTLRSNSKYNVVVSVHKADGPSQIKVS----------------LNGPS-YNET 64

Mouse    87 VSIKIPASKEFNSDKEGHKYVTVVANFGETVVEKAVMV-SFQSGY------LFIQTDKTIYTPGS 144
            ..|::|.....|.:.|..|..|...|.....|...|.. |.:..|      :|:||||..|.|..
  Fly    65 KQIELPPMSTQNVEFEVPKLATGNYNLSAEGVSGVVFKNSTKLNYADKKPSVFVQTDKATYKPAD 129

Mouse   145 TVLYRIFTVDNNLLP--VGK--TVVILIETPDGIPVKRDI-LSSNNQHGILPLSWNIPELVNMGQ 204
            .|.:||..:|.|..|  :.|  :|:|:....:.|....|: |:.....|.|.||    |...:|.
  Fly   130 LVQFRILFLDENTRPAKIEKPISVIIIDGAQNRIKQLSDVKLTKGVFSGELQLS----EQPVLGT 190

Mouse   205 WKIRAFYEHAPKQIFSAEFEVKEYVLPSFEVRVEPTETFYYIDDPNGLEVSIIAKFLYGKNVDGT 269
            |||....:...::  :..|||.:||||.|||.|:..:.....|  ..::.:|.||:.|||.|.|.
  Fly   191 WKISVSVDGDNRE--TKSFEVDKYVLPKFEVIVDTPKAVVIAD--KVIKATIRAKYTYGKPVKGK 251

Mouse   270 AFV-------IFG--VQDGDKKISLAHSLTRVVIEDGVGD---------------------AVLT 304
            |.|       .||  ..:|:|:       .:.:..||.|.                     ||:|
  Fly   252 ATVSMERSYGYFGDLNANGNKQ-------EKTIDVDGKGHVEFDIIHWAQRGQYLPPIKLFAVVT 309

Mouse   305 RKVLMEGVRPSNADALVGKSLYVSVTVILHSGSDMVEAERSGIPIVTSPYQIHFTKTPKFFKPAM 369
                         :.|.|.....:.||:||.....:|           ||:     .|:.|:...
  Fly   310 -------------EELTGNKQNATATVVLHQQRYSIE-----------PYE-----RPEHFEANK 345

Mouse   370 PFDLMVFVTNPDGSP----ASKVLVVTQGS-------------NAKALTQDDGVAKLSIN----- 412
            .|...|.|.|.||||    |..|.:....|             |.:|...::|:|..::.
  Fly   346 SFIYQVVVKNVDGSPVTNSAKNVKIGFDKSYSYFHEPSPKTRINFEAPVNENGIATFNVRLPDSD 410

Mouse   413 -------------------------TPNSRQPLTITVRTKKDTLPESRQATKTMEAHPYSTMHNS 452
                                     ||.||:||.|.|.|||..|.|.
  Fly   411 SRYYRIFASFDGSENTIGSISKFEPTPMSREPLKIQVNTKKPRLGEQ------------------ 457

Mouse   453 NNYLHLSVSRMELKPGDNLNVNFHLRTDPGHEAKIRYYTYLVMNKGKLLKAGRQVREPGQDLVVL 517
               :...|..:|..|                     |:.|.::.:|.::.:.......||....:
  Fly   458 ---VSFDVVSIEDLP---------------------YFVYTIVARGNVILSDYVDVPDGQKTYTV 498

Mouse   518 SLPITPEFIPSFRLVAYYTLIGASGQREVVADSVWVDVKDSCIGTLVVKGDPRDNHLAPGQQTTL 582
            ....|...:|...:..||.:     ..::..:...:|.:.....::.|..   ..:..|.::..|
  Fly   499 KFTPTFSMVPKATIYVYYVV-----NNDLQFEEKTIDFEKEFSNSIDVSA---PTNAKPSEEVKL 555

Mouse   583 RIEGNQGARVGLVAVDKGVFVLNKKNKLTQSKIWDVVEKADIGCTP---GSGKNYAGVFMDAGLA 644
            ||:.:..:.|||:.||:.|.:|...|.|:|..|::.:...... ||   |.|: |.|
  Fly   556 RIKTDADSFVGLLGVDQSVLLLKSGNDLSQDDIFNSLNIYQTS-TPWMNGYGR-YPG-------- 610

Mouse   645 FKTSQGLQTEQRADLEC-TKPAARRRRSVQLMERRMDKAGQYTDKGLRKCCEDGMRDIPMRYSCQ 708
             :|| ||.|...|:... |.|...                .|..:|.|.           .:..:
  Fly   611 -QTS-GLVTLTNANYPYNTGPLVM----------------SYVFEGSRH-----------PWITR 646

Mouse   709 RRARLITQGENCIKAFIDCCNHITKLREQHRRDHVLGLARS----ELEEDII---PEEDIISRSH 766
            .|.|:..:|::                    .|.:..|::|    .|:|.::   |:...| |..
  Fly   647 PRYRVGIRGDS--------------------GDRISFLSQSLNDRNLKEILLKQTPQRTTI-RKE 690

Mouse   767 FPQSWLWTIEELKEPEKNGISTKVMNIFLKDSITTWEILAVSLSDKKGICVA-DPYEIRVMQDFF 830
            ||::|.:  |.:.| |:..::.|:     .|:||:|.:...||:...||.:. :|.:|||.|.||
  Fly   691 FPETWFF--ENVGE-EEFTLTKKI-----PDTITSWVVTGFSLNPTSGIALTKNPSKIRVFQPFF 747

Mouse   831 IDLRLPYSVVRNEQVEIRAVLFNY---------------REQEELKVRVELLHNPAFCSMATAKN 880
            :...|||||.|.|.:.|..|:|||               :|.|..:...|:|..      |..:.
  Fly   748 VSTNLPYSVKRGEVIAIPVVIFNYLDKTLDADVVMDNSDQEYEFTEATNEVLEK------AIDEV 806

Mouse   881 RYFQTIKIPPKSSVAVPYVIVPLKIGQQEVEVKAAVFNHFISDGVKKTLKVVPEGMRI--NKTVA 943
            |..:.:.||..|..:|.::|.|..:|...:::.|.  :....|.:.:.|||.|||:.:  |:.|.
  Fly   807 RRVKRVTIPANSGKSVSFMIRPKNVGFTTLKITAT--SALAGDAIHQKLKVEPEGVTLFENRAVF 869

Mouse   944 IHTLDPEKLGQGGVQKVDVPAADLSDQVPDTDSETRIILQGSPVVQMAEDAVDGERLKHLIVTPA 1008
            |:..|..::.|.  ...|:|    ::.||.::     .::.|.|..:....:  :.|.:|:..|.
  Fly   870 INLKDQPEMSQS--LDADIP----NEVVPQSE-----FIEFSVVGDLLGPTL--QNLDNLVRMPY 921

Mouse  1009 GCGEQNMIGMTPTVIAVHYLDQTEQWEKFGIEKRQEALELIKKGYTQQLAFKQPSSAYAAF--NN 1071
            |||||||:...|.::.:.||:.|.:.......|.::.||:   ||.::|.:|....:|:||  ::
  Fly   922 GCGEQNMVNFVPNILVLKYLEVTGRKLPSVESKARKFLEI---GYQRELTYKHDDGSYSAFGKSD 983

Mouse  1072 RPPSTWLTAYVVKVFSLAANLIAIDSHVLCGAVKWLILEKQKPDGVFQEDGPVIHQEMIGGFRNA 1136
            ...||||||||::.|..|.....||..|:...:.:|: .|||..|.|.|.|.:        |.||
  Fly   984 ASGSTWLTAYVMRSFHQAGTYTDIDPKVITAGLDFLV-SKQKESGEFPEVGKL--------FDNA 1039

Mouse  1137 KEADVSLTAFVLIALQEARDICEGQVNSLPGSINKAGEYIEASYMNLQRPYTVAIAGYALAL-MN 1200
            .:..::||:|||:|..|..::    :.....:|.||..|:..........|::|||..||.| .:
  Fly  1040 NQNPLALTSFVLLAFFENHEL----IPKYQSAIKKAVRYVAEEADKTDDQYSLAIAAVALQLAKH 1100

Mouse  1201 KLEEPYLGKFLNTAK---DRNRWEE------PDQQLY-------NVEATSYALLALLLLKDFDSV 1249
            ...|..:.|..:.|:   ||..|.:      .|.:::       :||.|||.|||||.....:..
  Fly  1101 PQSEKVIAKLESVARKENDRMWWSKATESTGEDGRVFHWKPRSNDVEITSYVLLALLEKDPAEKA 1165

Mouse  1250 PPVVRWLNEQRYYGGGYGSTQATFMVFQALAQ--YQTDVPDHKDLNMDVSFHLPSRSSATTFRLL 1312
            .|:::||..||...||:.|||.|.:..|||.:  |:|.....   .||:.|. .:..|..|.::.
  Fly  1166 LPIIKWLISQRNSNGGFSSTQDTVIGLQALTKFAYKTGSGSG---TMDIEFS-SAGESKNTIKVN 1226

Mouse  1313 WENGNLLRSEE-TKQNEAFSLTAKGKGRGTLSVVAVYHAKLKSKVTCKKFDLRVSIRPAPETAKK 1376
            .||..:|::.: .|.......||||.|...:.:...|:...|.|        :.|.:..|.....
  Fly  1227 PENSLVLQTHDLPKSTRKVDFTAKGTGSAMVQLSYRYNLAEKEK--------KPSFKVTPTVKDT 1283

Mouse  1377 PEEAKNTMFLEICTKYL------GDVDATMSILDISMMTGFAPDTKDLELLASGVDRYISKYEMN 1435
            |.:   .:.:::|.:|:      .|.|:.|::::|::.:||..|:..|..: ..||| :.:.|..
  Fly  1284 PNQ---LLIVDVCAEYVPLEDADKDKDSNMAVMEIALPSGFVGDSTSLGKI-QAVDR-VKRVETK 1343

Mouse  1436 KAFSNKNTLIIYLEKISHTEEDCLTFKVHQYFNVGLIQPGSVKVYSYYNLEESCTRFYHPEKDDG 1500
               ::.:|:::|.:.::..:..||..:..:...|...:|.||.:|.||:.|...|.:|.
  Fly  1344 ---NSDSTVVVYFDSLTPGDVRCLPLEASKAHAVAKQKPASVSLYDYYDTERKATEYYQ------ 1399

Mouse  1501 MLSKLCHSEMCRCAE--ENC 1518
            :.|.||  ::|..|:  |.|
  Fly  1400 VKSSLC--DICEGADCGEGC 1417

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
C3	NP_033908.2	A2M_N	130..225	CDD:280081	30/105 (29%)
		A2M_N_2	458..603	CDD:285005	24/144 (17%)
		ANATO	678..747	CDD:237984	7/68 (10%)
		A2M	770..866	CDD:278630	34/111 (31%)
		complement_C3_C4_C5	996..1282	CDD:239226	97/306 (32%)
		A2M_comp	1051..1282	CDD:284982	80/251 (32%)
		A2M_recep	1398..1493	CDD:284981	23/94 (24%)
		NTR_complement_C3	1513..1661	CDD:239638	3/8 (38%)
		Interaction with CFP/properdin. /evidence=ECO:0000250|UniProtKB:P01024	1634..1659
Tep2	NP_523506.1	A2M_N	115..209	CDD:280081	29/99 (29%)
		A2M_N_2	445..576	CDD:285005	31/180 (17%)
		A2M	694..782	CDD:278630	32/95 (34%)
		A2M_2	909..1198	CDD:239227	97/306 (32%)
		A2M_comp	961..1199	CDD:284982	80/253 (32%)
		A2M_recep	1308..1398	CDD:284981	23/94 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840029
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11412
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.800