Protein Alignment PLD4 and Pld3

DIOPT Version :10

• Sequence 1: NP_001295103.1
• Gene: PLD4 / 122618
• HGNCID: 23792
• Length: 513
• Species: Homo sapiens
• Sequence 2: NP_610093.1
• Gene: Pld3 / 35384
• FlyBaseID: FBgn0032923
• Length: 494
• Species: Drosophila melanogaster
• Alignment Length: 485
• Identity: 179/485 - (36%)
• Similarity: 273/485 - (56%)
• Gaps: 39/485 - (8%)

Human    28 RRPWDREAGTLQVLGALAVLWLGSVALICLLWQVPRPPTWGQVQPKDVPRSWEHGSSPAWEPLEA 92
            |:...::||.:..:....:|:|||                ...||:  ||..::........||
  Fly    36 RQAAGQQAGQMVTVSLFMLLFLGS----------------SYFQPR--PRLHQYKGGRGHGLLE- 81

Human    93 EARQQRDSCQLVLVESIPQDLPSAAGSPSAQPLGQAWLQLLDTAQESVHVASYYWSLTGPDI-GV 156
                 :..|.:.||||||..|....|||......:|||:||::|..|:.:||:||:|...|. ||
  Fly    82 -----KFDCNIQLVESIPIGLTYPDGSPRFLSTYEAWLELLESATTSLDIASFYWTLKAEDTPGV 141

Human   157 NDSSSQLGEALLQKLQQLLGRN-------ISLAVATSSPTLARTSTDLQVLAARG-AHVRQVPMG 213
            :|:|::.||.:..:|  |...|       |.:.:|.|.|:....:.:.::||:.| |.|..:...
  Fly   142 SDNSTRPGEDVFARL--LANGNGGSRSPRIKIRIAQSEPSSGTPNLNTKLLASAGAAEVVSISFP 204

Human   214 R-LTRGVLHSKFWVVDGRHIYMGSANMDWRSLTQVKELGAVIYNCSHLAQDLEKTFQTYWVLGVP 277
            : ...||||:|.||||.:|.|:||||||||:||||||:|.::.||..|..|:.|.|..||.||..
  Fly   205 KYFGSGVLHTKLWVVDNKHFYLGSANMDWRALTQVKEMGVLVQNCPELTHDVAKIFGEYWYLGNS 269

Human   278 KAVLPKTWPQNFSSHFNRFQPFH-GLFDGVPTTAYFSASPPALCPQGRTRDLEALLAVMGSAQEF 341
            ::.....|...:::.:|...|.. .:........:.|:|||.|.|.|||.||.|:|..:.:|..:
  Fly   270 ESSRIPDWDWRYATSYNLKHPMQLSVNKNTSIEGFLSSSPPPLSPSGRTDDLNAILNTINTAITY 334

Human   342 IYASVMEYFPTTRFSHPPRYWPVLDNALRAAAFGKGVRVRLLVGCGLNTDPTMFPYLRSLQALSN 406
            :..:||:|:|...:.....|||.:|:|||.||..:||.|:||:....:::|:...||||||.|::
  Fly   335 VNIAVMDYYPLIIYEKNHHYWPFIDDALRKAAVERGVAVKLLISWWKHSNPSEDRYLRSLQDLAS 399

Human   407 PAANVSVDVKVFIVPV-GNHSNIPFSRVNHSKFMVTEKAAYIGTSNWSEDYFSSTAGVGLVVTQS 470
            ....:.:.::.||||. .:...|||.||||:|:|||::.|||||||||.|||:.|||:|||::::
  Fly   400 KEDKIDIQIRRFIVPTDSSQEKIPFGRVNHNKYMVTDRVAYIGTSNWSGDYFTDTAGIGLVLSET 464

Human   471 PGAQPAGATVQEQLRQLFERDWSSRYAVGL 500
            ...:... |::..||.:|||||:|:||..|
  Fly   465 FETETTN-TLRSDLRNVFERDWNSKYATPL 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PLD4	NP_001295103.1	PLDc_vPLD4_1	105..274	CDD:197243	75/178 (42%)
		PLDc_vPLD4_2	311..497	CDD:197246	82/186 (44%)
Pld3	NP_610093.1	PHA02820	89..493	CDD:222934	164/406 (40%)