DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Serping1 and Spn42Dd

DIOPT Version :9

Sequence 1:	NP_033906.2	Gene:	Serping1 / 12258	MGIID:	894696	Length:	504	Species:	Mus musculus
Sequence 2:	NP_001163067.1	Gene:	Spn42Dd / 49808	FlyBaseID:	FBgn0028988	Length:	372	Species:	Drosophila melanogaster

Alignment Length:	387	Identity:	108/387 - (27%)
Similarity:	177/387 - (45%)	Gaps:	71/387 - (18%)

- Green bases have known domain annotations that are detailed below.

Mouse   155 SVKLYHAFSATKMAKTNMAFSPFSIASLLTQVLLGAGDSTKSNLESILSYPKD--------FACV 211
            |.::|...|.:. ...|:..||.||.::|:.|.:||..||...|:|.|..|.:        :..:
  Fly    18 SKEIYQLLSKSH-TNQNLVVSPVSIETILSMVFMGAEGSTAKELQSALGLPSEDKEAVAARYGAL 81

Mouse   212 HQALKGFSSKGVTSVSQIFHSPD---------LAIRDTYVNASQSLYGSSPRVLGPDSAANLELI 267
            ...|:|.....:..::...:..|         ||:|:.:.:.::|:..::    ||.:|   |.|
  Fly    82 LNDLQGQEEGPILKLANRIYVNDQYSLNQNYNLAVREPFKSEAESISLTN----GPVAA---ERI 139

Mouse   268 NTWVAENTNHKIRKLLD--SLPSDTCLVLLNAVYLSAKWKITFEPKKMMAPFFY--KNSMIKVPM 328
            |.||.:.|:.||:.::|  |:.||...:|:||:|...:|:..|:|.|..|..|.  .|..:.|.|
  Fly   140 NQWVLDQTSGKIKGMIDPGSMTSDVKALLVNAIYFKGQWESKFDPAKTRASTFQVTANKSVPVQM 204

Mouse   329 MSSV-KYPVAQFDDHTLKAKVGQL-QLSHNLSFVIVVPVFPKHQLKDVE--KAL--------NPT 381
            |:.: .:....|.|  |.|:|.:| .|:.|||..|.:|       ::||  .||        .|.
  Fly   205 MAQMGTFRANYFRD--LDAQVIELPYLNSNLSMTIFLP-------REVEGLSALEEKIVGFARPL 260

Mouse   382 VFKAIMKKLELSKFLPTYLTMPHIKVKSSQDMLSVMEKLEFFD-FTYDLNLCGLTEDPD-LQVSA 444
            |.|.:            ||.:|..|::...::...:|||...: ||...:|.||..|.. .:||.
  Fly   261 VAKEV------------YLKLPKFKIEFRDELKETLEKLGIRELFTDKSDLSGLFADKSGGKVSQ 313

Mouse   445 MKHETVLELTESGVEAAAASAISF----GRSLPIFEVQRPFLFLLWDQQHRFPVFMGRVYDP 502
            :.|:..||:.|.|.|||.|::::.    |.| .......||.|::.|....:  |.|||..|
  Fly   314 VSHKAFLEVNEEGAEAAGATSVAVTNRAGFS-TFLMADHPFAFVIRDANTIY--FQGRVVSP 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Serping1	NP_033906.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..67
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	85..141
		serpinG1_C1-INH	141..500	CDD:381006	106/383 (28%)
Spn42Dd	NP_001163067.1	SERPIN	16..369	CDD:238101	105/382 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010